Submit Manuscript | http://medcraveonline.com posterior segment FBs is derived from metal fragments. A vegetative FB such as wood may reach inner part of eye but is located usually in the anterior segment [3,4]. Animal matter such as cilia can be carried along with denser matter to the posterior segment [1,2,5]. Ocular damage caused by intraocular foreign bodies (IOFB) can occur by two mechanisms; (1) penetrating injury with its secondary complications and (2) by the presence of IOFB itself causing damage from microbial endophthalmitis, toxicity and other inflammatory reactions [4,6,7]. Pathological evaluation of various FB in the eye and adnexa can give us bunch of information about the damages to the structures.
Aim:To study pathological significance of ophthalmic FB in a referral tertiary institute of north-east India.
Materials and MethodsThis is a hospital based, retrospective, laboratory study conducted in a tertiary ophthalmic institute of north-east India between 2010 to 2015. Different tissues including eyeball specimens received in ocular pathology laboratory were studied in details. Gross examinations were carried out in the (LEICA S6D) dissection microscope and were documented. Histopathological analysis was carried out with Hematoxylin and Eosin (H&E) stain, other special stains and polarizer were used in (ZEISS) microscope Axioskop 40 and documented in (AxioCamMRc) camera. Specialized stains included Perl's stain for iron body, tissue Grams's stain (GIS) for microorganisms, Grocott's methenamine silver stain (GMS) for fungus, periodic acid schiff stain (PAS) for fungus and basement membrane of different structures, Congo red for amyloid to see ancillary pathologies. Sixteen pathological specimens with various FBs were seen and classified. Further hospital records were reviewed for the clinical profile, and other ancillary investigations to correlate the findings.
ResultsSix cases of iron FB s were seen and acknowledged. One case of copper FB was seen in intraocular specimen with phthisical blind eye which was confirmed by scanning electron microscopy (SEM) (Figure 1a) and Energy dispersive X-ray spectroscopy (EDX) (Figure 1b). Three cases of vegetative FB were seen in the orbital/lid tissues (Figure 2). FBs were detected in pathological specimen of two sympathetic ophthalmia cases (Figure 3). Urate crystals were documented in one of the conjunctival specimen. (Figure 4a). One case of tripod glass wool FB (Mercedes Benz sign) was documented in a conjunctival specimen (Figure 4b). A case of insect body in the tissue (Figure 4c,d,e) and other case of cilia was detected in the cohort. All iron FB were identified and measured. Out of six iron FBs, four had positivity with Perl's stain in the tissue sections. One iron FB had changes in the lens and its surrounding in a phthisical enucleated eyeball. One out of the three cases of vegetative FB had associated fungal infection (Aspergillus). Results of all FBs are shown in Figure 5.
DiscussionManagement of eye trauma is of concern to both the beginner ophth...