A deazariboflavin chromophore kinetically stabilizes reduced FAD state in a bifunctional cryptochrome
Yuhei Hosokawa,
Hiroyoshi Morita,
Mai Nakamura
et al.
Abstract:An animal-like cryptochrome derived from Chlamydomonas reinhardtii (CraCRY) is a bifunctional flavoenzyme harboring flavin adenine dinucleotide (FAD) as a photoreceptive/catalytic center and functions both in the regulation of gene transcription and the repair of UV-induced DNA lesions in a light-dependent manner, using different FAD redox states. To address how CraCRY stabilizes the physiologically relevant redox state of FAD, we investigated the thermodynamic and kinetic stability of the two-electron reduced… Show more
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