A dataset resource for clinically associated phosphosites in hepatocellular carcinoma

Abstract

Phosphorylation is one of the most common post-translational modifications (PTMs) and is closely related to protein activity and function, playing a critical role during cancer development. Quantitative phosphoproteomic strategies have been widely used to study the underlying mechanisms of cancer progression or drug resistance.

Post‐translational modification and phenotype

“…The fourth group of articles are translational studies focusing on profiling PTMs or key PTM‐impacted proteomes for cancer research and biomarker discovery. In the first article , Meng et al presented a Dataset Brief for clinically associated phosphosites in hepatocellular carcinoma (HCC) [13]. By applying the well‐established statistical analysis, the authors mined the phosphoproteomic dataset in the previously published proteogeomic study on HCC to catalog those clinically important phosphosites strongly associated with overall survival, recurrence, and tumor stages in HCC.…”