A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables

Adams, Karen; Pinborg, Lars H.; Svarer, Claus; Hasselbalch, Steen G.; Holm, Søren; Haugbøl, Steven; Madsen, Karine; Frøkjær, Vibe G.; Martiny, Lars; Paulson, Olaf B.; Knudsen, Gitte M.

doi:10.1016/j.neuroimage.2003.10.046

Cited by 115 publications

(95 citation statements)

References 53 publications

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“…In a recent [ 123 I]nor-β-CIT SPECT study including 16 monozygotic twin pairs, twins with a BMI higher than their monozygotic co-twins were found to have higher SERT binding (Koskela et al, 2008). In two independent large samples of healthy human subjects we previously detected a positive association between BMI and global neocortical 5-HT 2A receptor binding (Adams et al, 2004;Erritzoe et al, 2009) supporting the notion that overweight subjects might have lower cerebral 5-HT levels (Roth et al, 1998;Cahir et al, 2007).…”

Section: Introductionmentioning

confidence: 53%

“…Finally, the binding potential was included as the dependent variable in the statistical analysis. In the present study, as well as in our prior analysis of 5-HT 2A receptor binding (Adams et al, 2004;Erritzoe et al, 2009) we chose the same approach. One could argue, however, that the causality between BMI and serotonergic neurotransmission should be reverted and that a more meaningful model would therefore include BMI as the dependent variable.…”

Section: Regionmentioning

confidence: 99%

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Cerebral serotonin transporter binding is inversely related to body mass index

et al. 2010

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Section: Introductionmentioning

confidence: 53%

Section: Regionmentioning

confidence: 99%

Cerebral serotonin transporter binding is inversely related to body mass index

et al. 2010

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“…Therefore, 5HT 1A receptors are believed to fundamentally modulate cortical excitation. (Wang et al, 1998) and D 2 (Farde et al, 1995;Antonini and Leenders, 1993), histamine H 1 (Yanai et al, 1992) and serotonin 5HT 2A (Adams et al, 2004;Meltzer et al, 1998;Sheline et al, 2002) demonstrate agedependent decline of the availability of receptors of the order of 10% pr decade. Transporters of dopamine (van Dyck et al, 2002) and serotonin (Yamamoto et al, 2002) also tend to decline with age.…”

Section: Discussionmentioning

confidence: 95%

Parametric and Regional Maps of Free Serotonin 5HT1A Receptor Sites in Human Brain as Function of Age in Healthy Humans

Møller

Jakobsen

Gjedde

2007

Neuropsychopharmacol

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(Gjedde, 2003;Rosa-Neto et al, 2004), which extrapolates measures of specific binding to an estimated steady-state. We compared these estimates in the two age groups with results obtained with the conventional Logan Plot and Simplified Reference Tissue Method (SRTM) applied to both regions of interestbased as parametric analyses. The regional distribution of specific binding of free sites [ 11 C]WAY-100635 was similar to that reported in previous studies, with the highest pBs in limbic structures and the raphé nuclei. Although the results of the three methods differed, pBs in the elderly subjects consistently were lower than those of young subjects. Thus, the correlation between pB and age applied to regionsof-interest revealed significant decline of pB at the rate of 3 or 4% per decade, and a 10% decline of the global mean 5HT 1A receptor-pB in elderly relative to young subjects. The results demonstrate that the number of available 5HT 1A -binding sites declines with age.

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“…PET and MR images were co-registered through manual translation and rotation of the PET image with subsequent visual inspection in three planes, as described in Adams et al (2004). Data analyses were carried out by the same person.…”

Section: Mr/pet Co-registrationmentioning

confidence: 99%

Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding

Frøkjær¹,

Vinberg

Erritzoe³

et al. 2009

Neuropsychopharmacol

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Life stress is a robust risk factor for later development of mood disorders, particularly for individuals at familial risk. Likewise, scoring high on the personality trait neuroticism is associated with an increased risk for mood disorders. Neuroticism partly reflects stress vulnerability and is positively correlated to frontolimbic serotonin 2A (5-HT 2A ) receptor binding. Here, we investigate whether neuroticism interacts with familial risk in relation to frontolimbic 5-HT 2A receptor binding. Twenty-one healthy twins with a co-twin history of mood disorder and 16 healthy twins without a co-twin history of mood disorder were included. They answered self-report personality questionnaires and underwent [ 18 F]altanserin positron emission tomography. We found a significant interaction between neuroticism and familial risk in predicting the frontolimbic 5-HT 2A receptor binding (p ¼ 0.026) in an analysis adjusting for age and body mass index. Within the high-risk group only, neuroticism and frontolimbic 5-HT 2A receptor binding was positively associated (p ¼ 0.0037). In conclusion, our data indicate that familial risk and neuroticism interact in their relation to frontolimbic 5-HT 2A receptor binding. These findings point at a plausible neurobiological link between genetic and personality risk factors and vulnerability to developing mood disorders. It contributes to our understanding of why some people at high risk develop mood disorders while others do not. We speculate that an increased stress reactivity in individuals at high familial risk for mood disorders might enhance the effect of neuroticism in shaping the impact of potential environmental stress and thereby influence serotonergic neurotransmission.

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A database of [18F]-altanserin binding to 5-HT2A receptors in normal volunteers: normative data and relationship to physiological and demographic variables

Cited by 115 publications

References 53 publications

Cerebral serotonin transporter binding is inversely related to body mass index

Cerebral serotonin transporter binding is inversely related to body mass index

Parametric and Regional Maps of Free Serotonin 5HT1A Receptor Sites in Human Brain as Function of Age in Healthy Humans

Familial Risk for Mood Disorder and the Personality Risk Factor, Neuroticism, Interact in Their Association with Frontolimbic Serotonin 2A Receptor Binding

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