A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury

Shen, He; Bai, Xu; Yang, Chao; Xue, Weiwei; You, Zhifeng; Wu, Xianming; Ma, Dezun; Shao, Dan; Leong, Kam W.; Dai, Jianwu

doi:10.1016/j.biomaterials.2021.121279

Cited by 87 publications

(55 citation statements)

References 43 publications

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“…Furthermore, in vivo tests revealed potential in enhancing locomotion recovery, reducing inflammation, promoting remyelination, and stimulating axon regeneration after SCI. Another hydrogel for SCI repair has been recently proposed by Shen and colleagues [111]. The authors created an immunoregulatory hydrogel that scavenges anionic damage-associated molecular patterns (DAMPs) and sustainedly releases IL-10 towards reducing the pro-inflammatory responses of macrophages and microglia, promoting the neurogenic differentiation of NSCs and ensuring axon growth formation without scar formation.…”

Section: Cell-free Scaffoldsmentioning

confidence: 99%

Novel Strategies for Spinal Cord Regeneration

Costăchescu

Niculescu

Dabija

et al. 2022

IJMS

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A spinal cord injury (SCI) is one of the most devastating lesions, as it can damage the continuity and conductivity of the central nervous system, resulting in complex pathophysiology. Encouraged by the advances in nanotechnology, stem cell biology, and materials science, researchers have proposed various interdisciplinary approaches for spinal cord regeneration. In this respect, the present review aims to explore the most recent developments in SCI treatment and spinal cord repair. Specifically, it briefly describes the characteristics of SCIs, followed by an extensive discussion on newly developed nanocarriers (e.g., metal-based, polymer-based, liposomes) for spinal cord delivery, relevant biomolecules (e.g., growth factors, exosomes) for SCI treatment, innovative cell therapies, and novel natural and synthetic biomaterial scaffolds for spinal cord regeneration.

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Section: Cell-free Scaffoldsmentioning

confidence: 99%

Novel Strategies for Spinal Cord Regeneration

Costăchescu

Niculescu

Dabija

et al. 2022

IJMS

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“…Human nerves are divided into two main types: the peripheral nervous system (PNS) and the central nervous system (CNS), including the brain and spinal cord (1)(2)(3). PNS and CNS injuries are often caused by traffic accidents, natural disasters, war damage, and iatrogenic side effects of surgery (4).…”

Section: Introductionmentioning

confidence: 99%

Regenerative Role of T Cells in Nerve Repair and Functional Recovery

Tang

Huang

et al. 2022

Front. Immunol.

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The immune system is essential in the process of nerve repair after injury. Successful modulation of the immune response is regarded as an effective approach to improving treatment outcomes. T cells play an important role in the immune response of the nervous system, and their beneficial roles in promoting regeneration have been increasingly recognized. However, the diversity of T-cell subsets also delivers both neuroprotective and neurodegenerative functions. Therefore, this review mainly discusses the beneficial impact of T-cell subsets in the repair of both peripheral nervous system and central nervous system injuries and introduces studies on various therapies based on T-cell regulation. Further discoveries in T-cell mechanisms and multifunctional biomaterials will provide novel strategies for nerve regeneration.

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“…For example, the physical entrapment of IL‐10 into gelatin‐based hydrogels reduced the proinflammatory responses of macrophages and led to scar‐less axon growth in a complete transaction mouse model. [ 18 ] IL‐10‐laden hyaluronic acid‐based hydrogels reduced fibrosis in a murine model of chronic kidney disease. [ 19 ] But most hydrogels have a mesh size larger than a typical protein molecule.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Microgels Support Proregenerative Macrophage Activation and Attenuate Fibroblast Collagen Synthesis

Mohammadi

Ravanbakhsh

Taheri

et al. 2022

Adv Healthcare Materials

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Scars composed of fibrous connective tissues are natural consequences of injury upon incisional wound healing in soft tissues. Hydrogels that feature a sustained presentation of immunomodulatory cytokines are known to modulate wound healing. However, existing immunomodulatory hydrogels lack interconnected micropores to promote cell ingrowth. Other limitations include invasive delivery procedures and harsh synthesis conditions that are incompatible with drug molecules. Here, hybrid nanocomposite microgels containing interleukin‐10 (IL‐10) are reported to modulate tissue macrophage phenotype during wound healing. The intercalation of laponite nanoparticles in the polymer network yields microgels with tissue‐mimetic elasticity (Young's modulus in the range of 2–6 kPa) and allows the sustained release of IL‐10 to promote the differentiation of macrophages toward proregenerative phenotypes. The porous interstitial spaces between microgels promote fibroblast proliferation and fast trafficking (an average speed of ≈14.4 µm h−1). The incorporation of hyaluronic acid further enhances macrophage infiltration. The coculture of macrophages and fibroblasts treated with transforming growth factor‐beta 1 resulted in a twofold reduction in collagen‐I production for microgels releasing IL‐10 compared to the IL‐10 free group. The new microgels show potential toward regenerative healing by harnessing the antifibrotic behavior of host macrophages.

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A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury

Cited by 87 publications

References 43 publications

Novel Strategies for Spinal Cord Regeneration

Novel Strategies for Spinal Cord Regeneration

Regenerative Role of T Cells in Nerve Repair and Functional Recovery

Immunomodulatory Microgels Support Proregenerative Macrophage Activation and Attenuate Fibroblast Collagen Synthesis

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