A daily skincare regimen with a unique ceramide and filaggrin formulation rapidly improves chronic xerosis, pruritus, and quality of life in older adults

Chang, Anne Lynn S.; Chen, Shuo; Osterberg, Lars; Brandt, Staci; Grote, Erika C. von; Meckfessel, Matthew H.

doi:10.1016/j.gerinurse.2017.05.002

Cited by 24 publications

(17 citation statements)

References 23 publications

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“…These cells are held together in the lipid matrix by corneodesmosomes, modified desmosomes from the uppermost nucleated epidermal layers. Also, intracellular humectants (natural moisturizing factors) that are essential for stratum corneumhydration, barrier homeostasis and desquamation localize in the corneocytes [8,9]. The ''mortar'' includes intercellular lipids arranged into lamellar layers consisting of cholesterol, free fatty acids, approximately ceramides (CERs) and sterol/wax esters.…”

Section: Skin Barriermentioning

confidence: 99%

Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

et al. 2019

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Human skin is the largest organ of the body and is an effective physical barrier keeping it from environmental conditions. This barrier function of the skin is based on stratum corneum, located in the uppermost skin. Stratum corneum has corneocytes surrounded by multilamellar lipid membranes which are composed of cholesterol, free fatty acids and ceramides (CERs). Alterations in ceramide content of the stratum corneum are associated with numerous skin disorders. In recent years, CERs have been incorporated into conventional and novel carrier systems with the purpose of exogenously applying CERs to help the barrier function of the skin. This review provides an overview of the structure, function and importance of CERs to restore the barrier function of the skin following their topical application.

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Section: Skin Barriermentioning

confidence: 99%

Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

et al. 2019

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“…Previous research showed that in German hospitals and nursing homes, almost every second person was affected by dry skin (Lechner, Lahmann, Neumann, Blume‐Peytavi, & Kottner, ; Lichterfeld, Lahmann, Blume‐Peytavi, & Kottner, ). Skin dryness can severely reduce the quality of life, and accompanied itching can disrupt sleep and causes emotional distress (Chang et al, ; Izumi et al, ). The disturbed skin barrier increases the risk of secondary infections (Chang et al, ), and studies indicate that xerosis may be an independent risk factor for the development of pressure ulcers/injuries (Coleman et al, ; Lechner et al, ).…”

Section: Introductionmentioning

confidence: 99%

“…Skin dryness can severely reduce the quality of life, and accompanied itching can disrupt sleep and causes emotional distress (Chang et al, ; Izumi et al, ). The disturbed skin barrier increases the risk of secondary infections (Chang et al, ), and studies indicate that xerosis may be an independent risk factor for the development of pressure ulcers/injuries (Coleman et al, ; Lechner et al, ). This emphasizes the importance of appropriate skincare interventions in nursing practice.…”

Section: Introductionmentioning

confidence: 99%

“…Dry skin can be effectively treated with adequate skincare interventions (Chang et al, ; Hahnel, Blume‐Peytavi, Trojahn, Dobos, Stroux, et al, ; Hahnel, Blume‐Peytavi, Trojahn, Dobos, Jahnke, et al, ; Moncrieff et al, ). It is recommended to use lipophilic leave‐on products containing humectants such as urea, dexpanthenol or glycerine.…”

Section: Introductionmentioning

confidence: 99%

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Dry skin and the use of leave‐on products in nursing care: A prevalence study in nursing homes and hospitals

et al. 2018

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AimsTo describe the prevalence of dry skin in nursing homes and hospitals and to describe relationships between topical skincare interventions and dry skin.DesignTwo multicentre descriptive cross‐sectional prevalence studies.MethodsThe studies were performed in German nursing homes and hospitals in 2015 and 2016. Data were collected by trained nurses based on a standardized data collection form. The severity of dry skin was measured using the Overall Dry Skin Score.ResultsIn total, 1,662 nursing home residents and 1,486 hospital patients participated. The prevalence of dry skin was 41.2% in nursing homes and 55.2% in hospitals. In case of skincare dependency, the proportions of participants with dry skin were higher, particularly in hospitals (70.2%). In both institutions, the application of leave‐on products increased when dry skin was present but remained lower in hospitals. Considering the high amount of skin dryness in skincare‐dependent participants, interventions seem not to be successful. Results indicate a need for skincare improvement in future.

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“…For some years now many studies have been conducted to identify such treatments. Besides clinical trials performed on aged vs. young subjects (Seyfarth et al, 2011;Danby et al, 2016;Chang et al, 2018), one can also find interesting information from studies done on patients with skin diseases characterized by a perturbation of stratum corneum lipids and a defective barrier, like atopic dermatitis, psoriasis or ichthyoses (Lowe et al, 2012;Liu et al, 2015;Sahle et al, 2015), as well as studies using animal or in vitro models (Di Marzio et al, 2008;Moner et al, 2018;Popa et al, 2018).…”

Section: Ceramides and Skin Ageingmentioning

confidence: 99%

Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses

Jonca

2019

OCL

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The outermost layer of the skin, the stratum corneum, is essential for the protective barrier functions of the skin. It results from the stacking of corneocytes, the dead flattened cells resulting from epidermal terminal differentiation of underlying living keratinocytes. The cornified lipid envelope, encapsulating corneocytes, and the extracellular mortar-like multilayered lipid matrix, called lamellae, are two crucial elements of the epidermal barrier. Stratum corneum extracellular lipids are mainly composed of ceramides, cholesterol and free fatty acids. Ceramides, and more specifically the epidermis specific ω-O-acylceramides, are essential for lipid-matrix organization into lamellae and formation of the corneocyte lipid envelope. Pathophysiological studies of inherited lipid metabolism disorders recently contributed to a better understanding of stratum corneum lipid metabolism. In the lab, our data from patients with Autosomal Recessive Congenital Ichthyosis and a murine knock-out model showed that the enzyme PNPLA1 is essential for the last step of synthesis of omega-O-acylceramides. Skin aging is a complex biological process caused by genetic and extrinsic factors e.g. sun exposure, smoke, and pollution. Aging skin is marked by a senescence-related decline in lipid and water content, which ultimately impairs epidermal barrier function. Thus, aged epidermis is prone to develop altered drug permeability, increased susceptibility to irritants contact dermatitis and severe xerosis. Ceramide deficiency may account, at least in part, for the dysfunction of the stratum corneum associated with ageing. Hence, treatments able to increase skin-ceramide levels could improve the epidermal barrier function in aged skin. Many animal testing and clinical trials are taken in that regard.

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A daily skincare regimen with a unique ceramide and filaggrin formulation rapidly improves chronic xerosis, pruritus, and quality of life in older adults

Cited by 24 publications

References 23 publications

Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin

Dry skin and the use of leave‐on products in nursing care: A prevalence study in nursing homes and hospitals

Ceramides metabolism and impaired epidermal barrier in cutaneous diseases and skin aging: focus on the role of the enzyme PNPLA1 in the synthesis of ω-O-acylceramides and its pathophysiological involvement in some forms of congenital ichthyoses

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