A–DA′D–A fused-ring small molecule-based nanoparticles for combined photothermal and photodynamic therapy of cancer

Lu, Bing; Zhang, Zhecheng; Jin, Danni; Yuan, Xiaolei; Wang, Jin; Ding, Yue; Wang, Yan; Yao, Yong

doi:10.1039/d1cc04629b

Cited by 29 publications

(32 citation statements)

References 36 publications

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“…This shape change has been observed in Y6 NPs made using re-precipitation. 31 However, our spectrum shows a lower relative amplitude of the lowest-energy peak than re-precipitation NPs, likely due to subtle morphological differences resulting from the two different preparation methods. The absorption spectra of the neat PM6 film and NPs have two major peaks (Figure 2b), corresponding to the S (0,0) → S (1,0) transition at 615 nm and the S (0,0) → S (1,1) transition at 570 nm.…”

Section: Steady-state Absorption and Emissionmentioning

confidence: 68%

Red-Light-Mediated Photocatalytic Hydrogen Evolution by Hole Transfer from Non-Fullerene Acceptor Y6

Kee

Perrelle

Dolan

et al. 2022

Preprint

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One of the highest performing materials in organic photovoltaics is a blend of the polymer donor PM6 and non-fullerene acceptor (NFA) Y6. We report the use of 1:1 PM6:Y6 blend nanoparticles (NPs) prepared by the miniemulsion method for the photocatalytic production of hydrogen under sacrificial conditions, with a 2% mass loading of Pt co-catalyst. When pre- pared using TEBS, a thiophene-containing surfactant, these blend NPs have a desirable inter- mixed morphology. Under ≈1-sun illumination from 400 to 900 nm, hydrogen is produced at a rate of 8000 ± 400 μmol h−1 g−1, which is among the highest reported for organic photocata- lysts under similar conditions. Remarkably, this rate remains high at 5200 ± 300 μmol h−1 g−1 under 650 −900 nm excitation, where Y6 is exclusively excited, generating free charges by hole transfer from Y6 to PM6. The rate drops to 2400 ± 200 μmol h−1 g−1 at 400 −600 nm excitation, where PM6 is preferentially excited and free charges are generated from the conventional electron transfer mechanism. Additionally, external quantum efficiencies of 0.27 ± 0.08% at 405nm, 0.19 ± 0.04% at 565nm, and 0.22 ± 0.02% at 780nm were measured, indicating that this photocatalyst uses a broad region of solar spectrum to yield hydrogen from excitation of both the donor and the acceptor. Transient absorption spectroscopy results show that both hole transfer and electron transfer occur following the excitation of Y6 and PM6, respectively. This work is the first study to show that free charge generation via hole transfer is the dominant mechanism of hydrogen evolution in a donor:NFA blend. This work also highlights the potential that other donor:NFA blends may have for highly efficient green hydrogen production.

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Section: Steady-state Absorption and Emissionmentioning

confidence: 68%

Red-Light-Mediated Photocatalytic Hydrogen Evolution by Hole Transfer from Non-Fullerene Acceptor Y6

Kee

Perrelle

Dolan

et al. 2022

Preprint

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“…The broad absorption profile has been observed previously in Y6 NPs prepared by re-precipitation. 33 In comparison, the spectra in Figure 2 have a lower relative amplitude of the 820 nm peak, likely due to the difference in preparation method.…”

Section: Nanoparticle Characterizationmentioning

confidence: 94%

Surfactant Effects on Hydrogen Evolution by Small Molecule Non-Fullerene Acceptor Nanoparticles

Dolan

Perrelle

Milsom

et al. 2022

Preprint

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Organic donor:acceptor semiconductor nanoparticles (NPs) formed through the miniemul- sion method have been shown to be active photocatalysts. Here we report photocatalytic hydrogen (H2) evolution under sacrificial conditions with Pt as a co-catalyst by NPs comprising only the non-fullerene acceptor Y6, stabilized by either sodium dodecyl sulfate (SDS) or the thiophene-containing surfactant 2-(3-thienyl)ethyloxybutylsulfonate sodium salt (TEBS). Typically, changes in the photocatalytic activity of donor:acceptor NPs are associated with differences in morphology due to the use of surfactants. However, as these NPs are single-component, their photocatalytic activity has a significantly lower dependence on morphology than two-component donor:acceptor NPs. Results from ultrafast transient absorption spectroscopy show a minor difference between the photophysics of the TEBS- and SDS-stabilized Y6 NPs, with free charges present with either surfactant. The similar photophysics suggest that both TEBS- and SDS-stabilized Y6 NPs would be expected to have similar rates of H2 evolution. However, the results from photocatalysis show that Y6 NPs stabilized by TEBS have a H2 evolution rate 21 times higher than that of the SDS- stabilized NPs under broadband solar-like illumination (400–900 nm). Transmission electron microscopy images of the Y6 NPs show effective photodeposition of Pt on the surface of the TEBS-stabilized NPs. In contrast, photodeposition of Pt is inhibited when SDS is used. Furthermore, the zeta potential of the NPs is higher in magnitude when SDS is present. Hence, we hypothesize that SDS forms a dense, insulating layer on the NP surface which hinders the photodeposition of Pt and reduces the rate of H2 evolution. This insulating effect is absent for TEBS-stabilized Y6 NPs, allowing a high rate of H2 evolution. The TEBS-stabilized Y6 NPs have a H2 evolution rate higher than most single-component organic photocatalysts, signaling the potential use of the Y-series acceptors for H2 evolution in Z-scheme photocatalysis.

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“…The high photothermal conversion and superior photodynamic activity make Y6 NPs with great potential for combinatorial PTT and PDT against cancer. 59 Nie and coworkers developed multifunctional Ce6-loaded plasmonic gold vesicles (GV-Ce6) for tri-modal fluorescence/photothermal/photoacoustic imaging-guided combinatorial PTT/PDT ( Fig. 2b ).…”

Section: Nanotechnology-based Strategies For Combinatorial Phototherapymentioning

confidence: 99%

Nanotechnology-based combinatorial phototherapy for enhanced cancer treatment

et al. 2022

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A–DA′D–A fused-ring small molecule-based nanoparticles for combined photothermal and photodynamic therapy of cancer

Abstract: New nanoparticles (Y6 NPs) based on an A−DA’D−A fused-ring conjugated small molecule Y6 have been prepared for the combined photothermal and photodynamic therapy of cancer. Y6 NPs show excellent light...

Cited by 29 publications

References 36 publications

Red-Light-Mediated Photocatalytic Hydrogen Evolution by Hole Transfer from Non-Fullerene Acceptor Y6

Red-Light-Mediated Photocatalytic Hydrogen Evolution by Hole Transfer from Non-Fullerene Acceptor Y6

Surfactant Effects on Hydrogen Evolution by Small Molecule Non-Fullerene Acceptor Nanoparticles

Nanotechnology-based combinatorial phototherapy for enhanced cancer treatment

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