A CZT-based blood counter for quantitative molecular imaging

Espagnet, Romain; Frezza, Andrea; Martín, J. P.; Hamel, L. A.; Lechippey, Laëtitia; Beauregard, Jean-Mathieu; Després, Philippe

doi:10.1186/s40658-017-0184-5

Cited by 4 publications

(6 citation statements)

References 26 publications

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“…Highly trained staff are required to collect samples and perform measurements in real time during the procedure (14-16). In the process, they are at an increased risk for exposure to radiation and blood pathogens (15,16). Sample rates are limited because of the operations involved, which can lead to undersampling of the input function (14)(15)(16).…”

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confidence: 99%

“…In the process, they are at an increased risk for exposure to radiation and blood pathogens (15,16). Sample rates are limited because of the operations involved, which can lead to undersampling of the input function (14)(15)(16). Human and equipment errors can lead to measurement variability (14)(15)(16).…”

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confidence: 99%

“…Automatic ex vivo measurements suffer from dispersion effects that must be corrected (14,15). They can require significant shielding (14,15) and multiple system components (16) (e.g., tubing, collection and waste containers, sources of pressure and vacuum), all of which add to complexity.…”

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confidence: 99%

“…Both automated and manual blood sampling require equipment sterilization, can cause patient discomfort, can require large volumes of blood to be drawn, and, in rare cases, can lead to medical complications (15).…”

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confidence: 99%

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Practical Clinical Measurement of Radiotracer Concentration in Blood: Initial Device Concept and Feasibility Testing

Knowland

Lattanze

Kingg

et al. 2018

J. Nucl. Med. Technol.

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Kinetic analysis of PET data requires continuous measurement of radioactivity in the arterial blood throughout the acquisition time, termed the arterial input function. The arterial input function is used as an input to compartmental modeling, which can be a better predictor of disease progression than SUV measurements from static PET images. Current common methods of measuring blood concentrations include image-derived, population-based, and manual sampling. These all have challenges due to logistical and technologic issues, as well as patient burden. The aim of this study was to design, develop, and assess a device that is practical and effective for the routine measurement of β-emitting radiotracer concentration in blood without the drawbacks of current methods and for which metabolite analysis is not required. Designs that integrated a scintillating fiber and a silicon photomultiplier with a general-purpose venous access catheter for in vivo measurement were considered. Other design requirements included miniaturization, high sampling rates, and stopping power for β-particles. Preliminary prototypes were designed to test the feasibility of the concept. Phantom tests were developed to mimic human vasculature. Tests of linearity, sensitivity, signal-to-noise ratios, the impact of vein diameter, and the influence of γ-radiation were conducted. Prototype sensors were constructed using 2 different diameters of polystyrene-based scintillating fibers. Fibers were custom-polished and fixed to a silicon photomultiplier. Sensor output was linear, with = 0.999 over the range from 0.037 to 9.25 MBq/mL. Absolute sensitivity was approximately 450 counts per second per MBq/mL. Measured signal-to-noise ratios ranged from 1.2:1 to 3.2:1 using a blood-to-tissue concentration ratio of 1:1. Sensor output increased with vein diameter and showed no sensitivity to γ-radiation. In experiments with phantom models, the prototype provided accurate measurements of β-emitting radiotracer concentration. The design will be refined for in vivo testing. The ability to routinely gather blood input function data would facilitate the adoption of kinetic modeling of PET data.

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confidence: 99%

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confidence: 99%

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Practical Clinical Measurement of Radiotracer Concentration in Blood: Initial Device Concept and Feasibility Testing

Knowland

Lattanze

Kingg

et al. 2018

J. Nucl. Med. Technol.

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“…Most of these gamma detection devices use scintillation crystals (such as BGO [27], GSO [224], NaI [157] or LYSO [179]) coupled to a photomultiplier tube (PMT). However, alternatives to PMT have also been proposed, such a CZT-based device [56] and a LSO crystal coupled to an avalanche photodiode (APD) [31], which is more compact and can operate under magnetic fields, although APD gain is highly temperature dependent.…”

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confidence: 99%

Advanced Imaging Techniques for Cardiovascular Research

Jimeno¹

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Declaración de Autoría y Originalidad iiiVisto Bueno de los Directores v Agradecimientos ix * DOTA is the abbreviated name of the chelator 1,4,7,10-tetraazacyclododecane-N,N ,N ,N -tetraacetic acid * These values are approximate; to date, there is no consensus over the optimal cut off values, and many possibilities can be found in the literature.† FDA refers to Food and Drug Administration: the federal agency of the US Department of Health and Human Services that regulates the use of radiopharmaceuticals in humans.

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The ultra high sensitivity blood counter: a compact, MRI-compatible, radioactivity counter for pharmacokinetic studies in μl volumes

Convert

Sarrhini²,

Paillé³

et al. 2022

Biomed. Phys. Eng. Express

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Quantification of physiological parameters in preclinical pharmacokinetic studies based on nuclear imaging requires the monitoring of arterial radioactivity over time, known as the arterial input function (AIF). Continuous derivation of the AIF in rodent models is very challenging because of the limited blood volume available for sampling. To address this challenge, an Ultra High Sensitivity Blood Counter (UHS-BC) was developed. The device detects beta particles in real-time using silicon photodiodes, custom low-noise electronics, and 3D-printed plastic cartridges to hold standard catheters. Two prototypes were built and characterized in two facilities. Sensitivities up to 39% for 18F and 58% for 11C-based positron emission tomography (PET) tracers were demonstrated. 99mTc and 125I based Single Photon Emission Computed Tomography (SPECT) tracers were detected with greater than 3% and 10% sensitivity, respectively, opening new applications in nuclear imaging and fundamental biology research. Measured energy spectra show all relevant peaks down to a minimum detectable energy of 20 keV. The UHS-BC was shown to be highly reliable, robust towards parasitic background radiation and electromagnetic interference in the PET or MRI environment. The UHS-BC provides reproducible results under various experimental conditions and was demonstrated to be stable over days of continuous operation. Animal experiments showed that the UHS-BC performs accurate AIF measurements using low detection volumes suitable for small animal models in PET, SPECT and PET/MRI investigations. This tool will help to reduce the time and number of animals required for pharmacokinetic studies, thus increasing the throughput of new drug development.

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A CZT-based blood counter for quantitative molecular imaging

Cited by 4 publications

References 26 publications

Practical Clinical Measurement of Radiotracer Concentration in Blood: Initial Device Concept and Feasibility Testing

Practical Clinical Measurement of Radiotracer Concentration in Blood: Initial Device Concept and Feasibility Testing

Advanced Imaging Techniques for Cardiovascular Research

The ultra high sensitivity blood counter: a compact, MRI-compatible, radioactivity counter for pharmacokinetic studies in μl volumes

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