A cytotoxic drug against reperfusion injury?

Rüdiger, Hannes A.; Clavien, Pierre‐Alain

doi:10.1002/hep.510310240

Cited by 14 publications

(7 citation statements)

References 38 publications

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“…PC is easy to apply, inexpensive and does not require the use of drugs with possible side effects. One disadvantage of preconditioning is that it requires a period of preischemic manipulation for organ protection [90,91].…”

Section: Iv2 Strategies Designed In Past Years To Prevent Hepatic Imentioning

confidence: 99%

Endoplasmic Reticulum Stress Inhibition Enhances Liver Tolerance to Ischemia/Reperfusion

Peralta

Brenner

2011

CMC

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In many physiopathological conditions, the cell controls its proper dysfunction via activation of the unfolded protein response to restore efficient protein synthesis and folding in the endoplasmic reticulum. However, whether the aim of unfolded protein response is to promote the cell survival, it can also lead to induction of cell death and then affect the cell fate. Recently, endoplasmic reticulum stress appeared to be critical for acute as well as chronic diseases including neurodegeneration, cardiac disease, cancer, obesity, type 2 diabetes, and ischemia/reperfusion injury. Therefore, inhibition of the endoplasmic reticulum stress could constitute a promising therapeutic strategy to limit cellular damage in pathologies such as hepatic ischemia/reperfusion.

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Section: Iv2 Strategies Designed In Past Years To Prevent Hepatic Imentioning

confidence: 99%

Endoplasmic Reticulum Stress Inhibition Enhances Liver Tolerance to Ischemia/Reperfusion

Peralta

Brenner

2011

CMC

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“…9 The concept of ischemic preconditioning is based on the biologic principle that tissue primed by various types of sublethal stress develops tolerance to subsequent lethal injury. 18 In 1986, Murry et al 19 identified in the heart the protective potential of a short period of ischemia (ischemic preconditioning) in preventing injury from subsequent prolonged periods of ischemia. The protective effects of ischemic preconditioning were subsequently described in various tissues, including the liver.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Ischemic Preconditioning and Intermittent and Continuous Inflow Occlusion in the Murine Liver

Rüdiger¹,

Kang²,

Sindram³

et al. 2002

Annals of Surgery

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118

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“…These involve the generation of ROS and NO. These agents are highly reactive in all cell types (ROS) and can have significant vascular effects (2,124) and inhibit contraction of the bile canaliculus hence contributing to cholestasis (NO) (23).…”

Section: Ischemic Preconditioning Attenuates Ischemia-reperfusion Injurymentioning

confidence: 99%

Hepatic Ischemia-Reperfusion Injury: Roles of Ca2+ and Other Intracellular Mediators of Impaired Bile Flow and Hepatocyte Damage

et al. 2006

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Liver resection and liver transplantation have been successful in the treatment of liver tumors and end-stage liver disease. This success has led to an expansion in the pool of patients potentially treatable by liver surgery and, in the case of transplantation, to a shortage of liver donors. At present, there are significant numbers of potential candidates for liver resection and liver donation who have fatty livers, are aged, or have livers damaged by chemotherapy. All of these are at high risk for ischemic reperfusion (IR) injury. The aims of this review are to assess current knowledge of the clinical effectiveness of ischemic preconditioning and intermittent ischemia in reducing IR damage in liver surgery; to evaluate the use of bile flow as a sensitive indicator of IR liver damage; and to analyze the molecular mechanisms, especially intracellular Ca2+, involved in IR injury and ischemic preconditioning. It is concluded that bile flow is a sensitive indicator of IR injury. Together with reactive oxygen species (ROS) and other extracellular and intracellular signaling molecules, intracellular Ca2+ in hepatocytes plays a key role in the normal regulation of bile flow and in IR-induced injury and cell death. Ischemic preconditioning is an effective strategy to reduce IR injury but there is considerable scope for improvement, especially in patients with fatty and aged livers. The development of effective new strategies to reduce IR injury will depend on improved understanding of the molecular mechanisms involved, especially by gaining a better perspective of the relative importance of the various intrahepatocyte signaling pathways involved.

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A cytotoxic drug against reperfusion injury?

Cited by 14 publications

References 38 publications

Endoplasmic Reticulum Stress Inhibition Enhances Liver Tolerance to Ischemia/Reperfusion

Endoplasmic Reticulum Stress Inhibition Enhances Liver Tolerance to Ischemia/Reperfusion

Comparison of Ischemic Preconditioning and Intermittent and Continuous Inflow Occlusion in the Murine Liver

Hepatic Ischemia-Reperfusion Injury: Roles of Ca2+ and Other Intracellular Mediators of Impaired Bile Flow and Hepatocyte Damage

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