A cytological study of storage and secretion in the developing liver of the mouse

Deane, Helen Wendler

doi:10.1002/ar.1090880204

Cited by 17 publications

(2 citation statements)

References 12 publications

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“…Therefore, lipid droplet distribution is an important parameter for evaluating the liver's lipid metabolic function, as an altered pattern suggests altered lipid function, this is in spite of lipid demonstrable in the histological sections being only a part of the hepatic lipid reserves. The observed intense fatty change in the central region of the hepatic lobule in rats after trypan blue injections suggests low oxygen tension in the central part of the lobule interfering with rapid oxidation or phosphorylation of the fat [62]. The observation of more intense staining (SBB) in zone 3 (centrilobular) than in zone 1 (periportal) was suggestive of no modification of the adult pattern of lipid droplet distribution following the exposure to arsenic-administered in this study.…”

Section: Discussionmentioning

confidence: 68%

Preliminary morphological and biochemical changes in rat liver following postnatal exposure to sodium arsenite

2012

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The effects of sodium arsenite exposure on the hepatic maturation period of cellular and functional reorganization in developing rat livers were evaluated. Animals received intraperitoneal injections of sodium arsenite (1.5 mg/kg body weight) or distilled water on days 9 to 28 after birth. On day 29, the animals were sacrificed either by cervical dislocation or by perfusion fixation. The perfusion fixed liver tissue was processed for paraffin embedding, sectioning and hematoxylin and eosin staining. The fresh liver tissue was processed for cryo-sectioning followed by Sudan Black B staining and for biochemical estimation of reduced glutathione. Microscopic observation revealed comparable preserved hepatic lobular patterns and distributions of uninucleate and binucleate hepatocytes in the control and the experimental groups. The mean nuclear area and diameter of the hepatocytes was increased in the experimental group. Lipid droplet distribution pattern in Sudan Black B stained sections revealed higher staining intensity towards the centrilobular area in both groups. Semiquantitative estimation of staining intensity showed lower mean gray values in zone 3 than in zones 2 and 1 (suggestive of the setting in of the adult pattern) in both groups. The reduced glutathione levels in the liver tissue and the altered nuclear size of the hepatocytes in the experimental group suggested the impairment of morphological and biochemical processes induced by arsenic exposure during the postnatal period.

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Section: Discussionmentioning

confidence: 68%

Preliminary morphological and biochemical changes in rat liver following postnatal exposure to sodium arsenite

2012

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“…During this period, the quantity of fat in the fetal liver rises but at birth there is both marked glyco genolysis and reduction of liver fat. Deane (22) -has presented a cytological study of storage and secretion in the developing liver of the mouse from birth to 45 days. Glycogen is present in the hepatic cells at birth and increases up to the 18th day.…”

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confidence: 99%

Developmental Physiology

Flexner¹

1946

Annu. Rev. Physiol.

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voted to a presentation of the recent additions to our understand ing of the development of the mammalian embryo and fetus. The fie�d is one of exceptional breadth and considerable activity for it has stimulated interest in many branches of animal biology. Con tributing to it are the classical embryologist and anatomist inter ested primarily in problems of morphogenesis; the physiologist and zoologist investigating the development of function; the biochem ist concerned with chemical differentiation and the chemical dif ferences which exist between typical and atypical cellular growth; the obstetrician and pediatrician who add a clinical interest to problems of fetal nutrition and of fetal anomalies. It will be ap parent that these various points of view are interdependent and that a presentation of progress in developmental physiology must include the advances made in its closely related fields of interest.

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Choline deficiency in the mouse

Meader

Williams

1957

Am. J. Anat.

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A cytological study of storage and secretion in the developing liver of the mouse

Cited by 17 publications

References 12 publications

Preliminary morphological and biochemical changes in rat liver following postnatal exposure to sodium arsenite

Preliminary morphological and biochemical changes in rat liver following postnatal exposure to sodium arsenite

Developmental Physiology

Choline deficiency in the mouse

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