A Cytogenetic Study of a Cardiac Papillary Fibroelastoma

Papillary fibroelastoma, a rare but potentially treatable cause of embolic stroke: Report of three cases

“…The side line had an additional isochromosome for the long arm of chromosome 11. The significance of the abnormal stem and side lines observed in this case is not certain but may indicate that the lesion develops by a neoplastic process 8 …”

“…Identification of papillary fibroelastoma is important because it represents a surgically correctable cause of cardiac embolic events. Surgical excision should be recommended regardless of symptoms because of the potential for embolisation 8–13 . Surgical excision with re‐constitution of the valve is recommended therapy for papillary fibroelastomas: in one series, 91% of patients who underwent surgery for valvular papillary fibroelastoma were treated with excision of the tumour and valve repair.…”

“…The significance of the abnormal stem and side lines observed in this case is not certain but may indicate that the lesion develops by a neoplastic process. 8 Review of previously published reports reveals 100 cases of papillary fibroelastoma diagnosed in life and confirmed at operation. Thromboembolism is a wellrecognised complication of fibroelastoma, as documented in our series of cases.…”

“…Surgical excision should be recommended regardless of symptoms because of the potential for embolisation. [8][9][10][11][12][13] Surgical excision with reconstitution of the valve is recommended therapy for papillary fibroelastomas: in one series, 91% of patients who underwent surgery for valvular papillary fibroelastoma were treated with excision of the tumour and valve repair. Only 10% required valve replacement.…”

Left Atrium Papillary Fibroelastomas: A Cause of Cerebral Emboli

“…Multiple theories have been advocated: inflammatory reaction of infection, neoplasms, congenital malformation, or organized thrombi. Two cytogenetic studies [4, 5] showed a structural rearrangement involving chromosomes 5 and 21. A prior study suggested a balanced translocation in both stemline clones in the case, whereas the second case showed unbalanced rearrangement in only the sideline clone [5].…”