Abstract:Introduction
Cabergoline is a synthetic ergote dopamine agonist that is metabolized by CYP3A4, is applied in the treatment of Parkinson's disease (PD). Clarithromycin, one of macrolide antibiotics, is a potent inhibitor of the CYP3A4. We studied the effect of coadministration of clarithromycin with cabergoline in healthy male volunteers and in patients with PD.
Methods
Trial1: Ten healthy male volunteers were enrolled. Subjects were randomized to take a single oral dose of cabergoline 1mg/day for 6 days, or a … Show more
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