A cyclometalated trinuclear Ir(<scp>iii</scp>)/Pt(<scp>ii</scp>) complex as a luminescent probe for histidine-rich proteins

Sarkar, Ankita; Kumar, Ravi; Das, Bishnu; Ray, Partho Sarothi; Gupta, Parna

doi:10.1039/c9dt04720d

Cited by 17 publications

(11 citation statements)

References 44 publications

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“…The trinuclear complexes 3 and 6 were synthesised in a stepwise manner starting from complexes 1 and 4 , which were themselves synthesised following the literature method of Nonoyama [13] . The intermediates 2 and 5 were prepared according to the previously reported method, [10] in which the ‘complexes as ligands’ concept was adopted. Here, complexes 2 and 5 were used as ligands, and reaction with [Pt(dmso) 2 Cl 2 ] afforded the trinuclear complexes 3 and 6 .…”

Section: Resultsmentioning

confidence: 99%

“…Complexes 1-3 were synthesised following the procedure reported earlier. [10] Analytical grade solvents were obtained from commercial suppliers and dried by the usual methods prior to use. Elemental analysis was performed with aP erkinElmer CHN Analyzer (2400 series).…”

Section: Methodsmentioning

confidence: 99%

“…The starting materials IrCl 3 ⋅ 3H 2 O, 4‐(2‐pyridyl)benzaldehyde, 2,2′‐bipyridyl, 2,2′‐bipyridine‐4,4′‐dicarbaldehyde, di‐2‐picolylamine and K 2 [PtCl 4 ] were purchased from Sigma–Aldrich and were used without further purification. Complexes 1 – 3 were synthesised following the procedure reported earlier [10] …”

Section: Methodsmentioning

confidence: 99%

“…A recent report from our group illustrates the application of trinuclear mixed-metal complexes as luminescent probes for histidine-rich proteins. [10] Here, we report the synthesis of six complexes in whicht he cyclometalated or ancillary ligand of two mononuclear cyclometalated iridium(III)c omplexes have been substituted in a stepwisem anner to yield trinuclear Pt-Ir-Pt complexes with a final Pt II -dipicolylamine scaffold anchored to ac yclometalating phenylpyridine [10] or ancillary bipyridyl ligand. In the former case (complex 3), one Pt II -di-2-picolylamine unit is appended to two different cyclometalating ligands, whereas in the latter case (complex 6), each pyridyl moiety of the 2,2'-bipyridyl ligandb earsaunit.…”

Section: Introductionmentioning

confidence: 99%

“…The proper choice of the second metal centre may help in designing heteronuclear metal complexes in which the cyclometallated Ir III core acts as the emissive centre and the other metal centre(s) provide a binding site for amino acids, nucleic acids or enzymes. A recent report from our group illustrates the application of trinuclear mixed‐metal complexes as luminescent probes for histidine‐rich proteins [10] …”

Section: Introductionmentioning

confidence: 99%

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Phosphorescent Trinuclear Pt–Ir–Pt Complexes: Insights into the Photophysical and Electrochemical Properties and Interaction with Guanine Nucleobase

Das

Borah

Ganguli

et al. 2020

Chemistry A European J

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In this studyw eh ave analysed the comparative photophysical and electrochemical properties of two isomeric heterotrinuclear Pt II-Ir III-Pt II complexes 3 and 6 and the four corresponding intermediate isomeric homonuclear cyclometalated iridium(III) complexes 1, 2, 4 and 5.T he isomerisation originates from positional differences in the formyl,d i-2-picolylamine and Pt-di-2-picolylaminem oieties appended to cyclometalated or ancillary ligands.The interaction of 5'-GMP with the trinuclearc omplexes 3 and 6 shows that platinumc entres appended to the cyclometalated ligandi n3 facilitatet he binding of two 5'-GMPu nits per Pt II centrei npreference to as ingle 5'-GMP unit per Pt II centre as observed in 6.T he 1:2a nd 1:1P t II-5'-GMP binding patterns probablya rise from the convenient arrangements of the Ptdi-2-picolylamine units in different planes in complex 3, whichi sa bsentinc omplex 6.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Phosphorescent Trinuclear Pt–Ir–Pt Complexes: Insights into the Photophysical and Electrochemical Properties and Interaction with Guanine Nucleobase

Das

Borah

Ganguli

et al. 2020

Chemistry A European J

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Trinuclear Organometallic Pt−Ir−Pt Complexes: Insights into Photophysical Properties, Amino Acid Binding and Protein Sensing

Das

Gupta

2021

Chemistry An Asian Journal

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The rational synthesis of trinuclear emissive organometallic complexes with two equivalent platinum(II) centres appended to the ancillary substituted 2,2′‐bipyridyl ligand of the cyclometalated iridium(III) centre is reported here. The alkynyl‐platinum moiety and cyclometalated iridium(III) centres have been separated through a non‐conjugated CH2−O−CH2 linkage. The emission titration with amino acids reveals that the complexes sense free amino acids. The luminescence sensing of BSA is thus attributed to the amino acid sensing ability of the complexes and confirmed by emission anisotropy and Far‐UV CD spectral study. The decrease in α‐helix in the CD spectra signifies the changes in the secondary structure of protein in presence of the complexes.

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Application of Mono and Trinuclear Cyclometalated Iridium (III) Complexes in Differential Bacterial Imaging and Antimicrobial Photodynamic Therapy

Das,

Biswas,

Mallick

et al. 2024

Chemistry A European J

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The application of transition metal complexes for antimicrobial photodynamic therapy (PDT) has emerged as an attractive alternative in mitigating a broad range of bacterial pathogens, including multidrug‐resistant pathogens. In view of their photostability, long excited‐state lifetimes, and tunable emission properties, transition metal complexes also contribute as bioimaging agents. In the present work, we designed mono and trinuclear cyclometalated iridium(III) complexes to explore their imaging application and antibacterial potential. For this, we used Methicillin‐resistant S. aureus (MRSA), the most prevalent of community‐associated (CA) multidrug‐resistant (MDR) bacteria (CA MDR) and Lactococcus lactis (L. lactis) as Gram‐positive while Campylobacter jejuni (C. jejuni) and E. coli as Gram‐negative bacteria. In addition to differential bioimaging of these bacteria, we assessed the antibacterial effects of both mono and trinuclear Ir(III) complexes under exposure to 427 nm LED light. The data presented herein strongly suggest better efficacy of trinuclear Ir(III) complex over mononuclear complex in imparting photoinduced cell death of MRSA. Based on the safety profile of these complexes, we propose that trinuclear cyclometalated iridium(III) complex hold great promise for selective recognition and targeting MDR bacteria with minimal off‐target effect.

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A cyclometalated trinuclear Ir(iii)/Pt(ii) complex as a luminescent probe for histidine-rich proteins

Abstract: A trinuclear luminescent organometallic Pt–Ir–Pt complex acts as an efficient protein staining agent due to reversible binding to histidine-rich proteins.

Cited by 17 publications

References 44 publications

Phosphorescent Trinuclear Pt–Ir–Pt Complexes: Insights into the Photophysical and Electrochemical Properties and Interaction with Guanine Nucleobase

Phosphorescent Trinuclear Pt–Ir–Pt Complexes: Insights into the Photophysical and Electrochemical Properties and Interaction with Guanine Nucleobase

Trinuclear Organometallic Pt−Ir−Pt Complexes: Insights into Photophysical Properties, Amino Acid Binding and Protein Sensing

Application of Mono and Trinuclear Cyclometalated Iridium (III) Complexes in Differential Bacterial Imaging and Antimicrobial Photodynamic Therapy

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