A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome

Benton, Emma; Crichton, Siobhan; Talpur, Rakhshandra; Agar, Nicholas; Fields, Paul; Wedgeworth, E.; Mitchell, Tracey; Cox, Michael C.; Ferreira, Sandra Reis; Liu, P.; Robson, Alistair; Calonje, Eduardo; Stefanato, Catherine M.; Wilkins, Bridget S.; Scarisbrick, Julia; Wain, E. Mary; Child, Fiona; Morris, Stephen; Duvic, Madeleine; Whittaker, Sean

doi:10.1016/j.ejca.2013.04.018

Cited by 131 publications

(171 citation statements)

References 29 publications

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“…Our study supports the previous literature, which suggests that advanced age and male sex are associated with poor survival [2,5,[13][14][15][16] . This is in keeping with the cutaneous lymphoma international prognostic index (CLIPi) for MF and SS, which lists male gender and age >60 as significant adverse prognostic factors [17] . When our data were included in a meta-analysis along with 2 other studies [2,3] , the results did not demonstrate a significant difference in OS between FMF and MF at 5 and 10 years.…”

Section: Discussionmentioning

confidence: 99%

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Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Giberson

Mourad²,

Gniadecki³

2017

Dermatology

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Background: Folliculotropic mycosis fungoides (FMF) is a distinct subtype of mycosis fungoides (MF) with unique clinicopathological features. The medical literature suggests that FMF has a more aggressive course and worse survival than classic MF. Previous studies do not use standardized treatment, and no studies have reported an association between treatment response and overall survival (OS). Objective: To compare OS for MF, FMF, and Sézary syndrome (SS) patients. Methods: Data were collected retrospectively from 218 patients (171 MF, 15 SS, 32 FMF) treated in a single academic center between 1970 and 2016. Results: Negative predictors of OS were age (OR = 1.07), male sex (OR = 1.63), and stage IIB, III, and IV (OR = 4.10, 5.42, and 7.54, respectively, vs. stage IA). Lack of initial PUVA response was strongly associated with negative OS (OR = 3.08). Kaplan-Meier analysis of age-, sex-, and stage-matched MF and FMF patients found similar OS between the 2 groups. The 5-year OS was 91% for FMF and 74% for MF. Meta-analysis of current data and 2 published studies where survival of FMF patients was compared to MF did not reveal statistically significant differences between these 2 diseases. Conclusions: When patients were matched for age, sex, and disease stage, folliculotropism did not affect OS in MF.

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Section: Discussionmentioning

confidence: 99%

“…it was found that patients with histologically classified advanced plaque-stage FMF had a similar course to patients with tumor-stage FMF. Plaque thickness and cutaneous thickness infiltrated in cutaneous T-cell lymphoma have been identified as predictors of worse survival [17] .…”

Section: Discussionmentioning

confidence: 99%

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Giberson

Mourad²,

Gniadecki³

2017

Dermatology

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“…Im Hinblick auf die Therapie ist Psoralen plus UVA (systemisch/Bad) nach aktuellen Berichten eine wirksame Option [33], ebenso eine Kombinationstherapie mit Bexaroten oder Interferon [34,35]. Benton EC et al zufolge ist das Vorliegen der follikulotropen Form ein signifikanter negativer prognostischer Faktor laut dem «cutaneous lymphoma international prognostic index» für die MF und das Sézary-Syndrom [36]. …”

Section: Kutanes T-zell-lymphomunclassified

Alopezien infolge von Medikamenten oder von anderen Haut- und systemischen Erkrankungen

Guzmán-Sánchez¹,

Asz-Sigall²

2016

Kompass Dermatol

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In diesem Kapitel werden die häufigsten Formen der Alopezie vorgestellt, die durch medikamentöse Therapien oder durch andere Hautkrankheiten und systemische Erkrankungen hervorgerufen werden können. Die folgenden Haarerkrankungen werden analysiert: das Telogeneffluvium (akut und chronisch); das Anageneffluvium; die follikulotrope Mycosis fungoides sowie Follikulitiden infolge von Bakterien, Pilzen, Parasiten, humanem Immundefizienzvirus, Lupus erythematodes und Sarkoidose. Dabei werden die Epidemiologie und Ätiologie, die klinische Manifestation und Diagnose sowie die aktuellen Therapien der einzelnen Krankheiten abgedeckt.

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“…With disease progression, the malignant T-cells can disseminate to lymph nodes, peripheral blood and internal organs, which carries an unfavorable prognosis. 4 Until now, many T-cell-related factors, including adhesion molecules, chemokines, and cytokines, have been linked to the pathogenesis of MF, particularly as MF is a disease of malignant T-cells. 1 A number of recent reports have focused on immune cytokines as factors linked to increasing growth of T-cells with tumor progression.…”

Section: Introductionmentioning

confidence: 99%

IL-32 induces indoleamine 2,3-dioxygenase⁺CD1c⁺ dendritic cells and indoleamine 2,3-dioxygenase⁺CD163⁺ macrophages: Relevance to mycosis fungoides progression

et al. 2017

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Mycosis fungoides (MF) progresses from patch to tumor stage by expansion of malignant T-cells that fail to be controlled by protective immune mechanisms. In this study, we focused on IL-32, a cytokine, highly expressed in MF lesions. Depending on the other cytokines (IL-4, GM-CSF) present during in vitro culture of healthy volunteers' monocytes, IL-32 increased the maturation of CD11cC myeloid dendritic cells (mDC) and/or CD163 C macrophages, but IL-32 alone showed a clear ability to promote dendritic cell (DC) differentiation from monocytes. DCs matured by IL-32 had the phenotype of skin-resident DCs (CD1c C ), but more importantly, also had high expression of indoleamine 2,3-dioxygenase. The presence of DCs with these markers was demonstrated in MF skin lesions. At a molecular level, indoleamine 2,3-dioxygenase messenger RNA (mRNA) levels in MF lesions were higher than those in healthy volunteers, and there was a high correlation between indoleamine 2,3-dioxygenase and IL-32 expression. In contrast, Foxp3 mRNA levels decreased from patch to tumor stage. Increasing expression of IL-10 across MF lesions was highly correlated with IL-32 and indoleamine 2,3-dioxygenase, but not with Foxp3 expression. Thus, IL-32 could contribute to progressive immune dysregulation in MF by directly fostering development of immunosuppressive mDC or macrophages, possibly in association with IL-10.

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A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome

Cited by 131 publications

References 29 publications

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Alopezien infolge von Medikamenten oder von anderen Haut- und systemischen Erkrankungen

IL-32 induces indoleamine 2,3-dioxygenase⁺CD1c⁺ dendritic cells and indoleamine 2,3-dioxygenase⁺CD163⁺ macrophages: Relevance to mycosis fungoides progression

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A cutaneous lymphoma international prognostic index (CLIPi) for mycosis fungoides and Sezary syndrome

Cited by 131 publications

References 29 publications

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Folliculotropism Does Not Affect Overall Survival in Mycosis Fungoides: Results from a Single-Center Cohort and Meta-Analysis

Alopezien infolge von Medikamenten oder von anderen Haut- und systemischen Erkrankungen

IL-32 induces indoleamine 2,3-dioxygenase+CD1c+ dendritic cells and indoleamine 2,3-dioxygenase+CD163+ macrophages: Relevance to mycosis fungoides progression

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IL-32 induces indoleamine 2,3-dioxygenase⁺CD1c⁺ dendritic cells and indoleamine 2,3-dioxygenase⁺CD163⁺ macrophages: Relevance to mycosis fungoides progression