A Customized Biohybrid Presenting Cascade Responses to Tumor Microenvironment
Feiyu Li,
Peipei Zhu,
Bingzhu Zheng
et al.
Abstract:Intrinsic characteristics of microorganisms, including non‐specific metabolism sites, toxic byproducts and uncontrolled proliferation constrain their exploitation in medical applications such as tumor therapy. Here, we report an engineered biohybrid that can efficiently target cancerous sites through a pre‐determined metabolic pathway to enable precise tumor ablation. In this system, DH5α Escherichia coli is engineered by the introduction of hypoxia‐inducible promoters and lactate oxidase genes, and further su… Show more
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