A CuS- and BODIPY-loaded nanoscale covalent organic framework for synergetic photodynamic and photothermal therapy

Abstract

Herein, we report a inorganic photothermal agent CuS and organic photosensitizer BODIPY loaded composite nanoscale COF material via a stepwise post-synthetic modification. The obtained CuS@COF-BDP can be a dual-mode therapeutic...

Metalated covalent organic frameworks: from synthetic strategies to diverse applications

“…According to the report of Dong et al , bifunctional CuS@COF-BDP nanomaterials were obtained by introducing ultrasmall CuS into TPB-DMTP-COF using copper acetate and thioacetamide as starting materials, followed by covalent modification of the amino groups on the TPB-DMTP-COF surface with a boron-dipyrromethene (BODIPY) photosensitizer. 837 Upon 520 nm laser irradiation, CuS@COF-BDP induces 1 O 2 generation for PDT. Upon 1064 nm laser irradiation, CuS@COF-BDP leads to an increase in the temperature of the illuminated region for PTT because of its near-infrared light absorption and photothermal conversion ability.…”

Composite materials based on covalent organic frameworks for multiple advanced applications

“…Through continuous efforts, COFs‐metal NPs composites have been used to achieve targeted delivery of glucose oxidase, [ 75 ] photodynamic and photothermal therapy, [ 76,77 ] pH‐responsice chemo/photothermal/chemodynamic synergistic therapy for cancer. [ 78 ]…”

“…Through continuous efforts, COFs-metal NPs composites have been used to achieve targeted delivery of glucose oxidase, [75] photodynamic and photothermal therapy, [76,77] pH-responsice chemo/photothermal/chemodynamic synergistic therapy for cancer. [78] The combination of photodynamic therapy (PDT) as well as photothermal therapy (PTT) has broad prospects in the treatment of tumors.…”

“…[216,228] As the therapeutic research of oncology drugs evolves from small molecules to nucleic acids, proteins, peptides, and antibodies, drug delivery technologies continue to evolve to meet the new challenges that come with it. [76] At the same time, COFs have been proved to be metal ion-free porous materials with less biotoxicity than MOFs, with large specific surface area and high porosity, and can be acted as carriers for drug delivery. The research related to COFs is on the rise.…”

A self-assembled nanophotosensitizer targets lysosomes and induces lysosomal membrane permeabilization to enhance photodynamic therapy

“…Boron-dipyrromethene (BOD) derivatives have been extensively explored as PSs for PDT owing to their high molar extinction coefficients, low dark toxicity, resistance to photobleaching, and high chemical stability. [36][37][38][39][40][41][42][43] BOD derivatives can also be systematically modified through organic synthesis to enhance their photophysical and pharmacokinetic properties and PDT efficacy. For example, heavy atom substitution of BOD can significantly increase single oxygen ( 1 O2) yield by enhancing intersystem crossing via spin-orbit coupling, 44,45 while enlargement of conjugation systems can red-shift the absorption toward the near-infrared region with deeper tissue penetration.…”