A curvature-based approach for left ventricular shape analysis from cardiac magnetic resonance imaging

Yeo, Si Yong; Zhong, Liang; Su, Yi; Tan, Ru San; Ghista, Dhanjoo N.

doi:10.1007/s11517-008-0401-4

Cited by 25 publications

(19 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous works, however, had been either of a qualitative nature or based on assumptions regarding ideal geometry of the ventricle. Our 3-D geometrical methodology uses an analytical approach to extract local differential properties and curvature information by means of local surface fitting (35,44,47,48). This approach was proven to be robust and produces accurate results, as shown by Garimella and Swartz (12) and Cazals and Pouget (6).…”

Section: Discussionmentioning

confidence: 99%

“…The methods of MRI data processing for LV have been developed and used in previous studies (35,44,47,48). Briefly, the MRI data were processed using a semi-automatic technique provided in the CMRtools suite (Cardiovascular Solutions).…”

Section: Subjectsmentioning

confidence: 99%

“…An in-house software was used to reconstruct the RV endocardial meshes at ED and ES as well as to calculate the surface shape descriptors, expressed in terms of local normal curvature and curvedness (35,44,47,48). To evaluate the shape at a particular point on the mesh, a local surface geometry was fitted to the region and the normal curvature was then calculated as (6,12):…”

Section: Subjectsmentioning

confidence: 99%

See 2 more Smart Citations

Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot

Zhong

Gobeawan

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

Self Cite

View full text Add to dashboard Cite

Tan RS, Kassab G. Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot. Am J Physiol Heart Circ Physiol 302: H1306 -H1316, 2012. First published December 30, 2011 doi:10.1152/ajpheart.00679.2011.-A quantitative understanding of right ventricular (RV) remodeling in repaired tetralogy of Fallot (rTOF) is crucial for patient management. The objective of this study is to quantify the regional curvatures and area strain based on three-dimensional (3-D) reconstructions of the RV using cardiac magnetic resonance imaging (MRI). Fourteen (14) rTOF patients and nine (9) normal subjects underwent cardiac MRI scan. 3-D RV endocardial surface models were reconstructed from manually delineated contours and correspondence between end-diastole (ED) and end systole (ES) was determined. Regional curvedness (C) and surface area at ED and ES were calculated as well as the area strain. The RV shape and deformation in rTOF patients differed from normal subjects in several respects. Firstly, the curvedness at ED (mean for 13 segments, 0.030 Ϯ 0.0076 vs. 0.029 Ϯ 0.0065 mm Ϫ1 ; P Ͻ 0.05) and ES (mean for 13 segments, 0.040 Ϯ 0.012 vs. 0.034 Ϯ 0.0072 mm Ϫ1 ; P Ͻ 0.001) was decreased by chronic pulmonary regurgitation. Secondly, the surface area increased significantly at ED (mean for 13 segments, 982 Ϯ 192 vs. 1,397 Ϯ 387 mm 2 ; P Ͻ 0.001) and ES (mean for 13 segments, 576 Ϯ 130 vs. 1,012 Ϯ 302 mm 2 ; P Ͻ 0.001). In particular, rTOF patients had significantly larger surface area than that in normal subjects in the free wall but not for the septal wall. Thirdly, area strain was significantly decreased (mean for 13 segments, 56 Ϯ 6 vs. 34 Ϯ 7%; P Ͻ 0.0001) in rTOF patients. Fourthly, there were increases in surface area at ED (5,726 Ϯ 969 vs. 6,605 Ϯ 1,122 mm 2 ; P Ͻ 0.05) and ES (4,280 Ϯ 758 vs. 5,569 Ϯ 1,112 mm 2 ; P Ͻ 0.01) and decrease in area strain (29 Ϯ 8 vs. 18 Ϯ 8%; P Ͻ 0.001) for RV outflow tract. These findings suggest significant geometric and strain differences between rTOF and normal subjects that may help guide therapeutic treatment. magnetic resonance imaging; curvature; right ventricular remodeling; deformation; three-dimensional reconstruction TETRALOGY OF FALLOT (TOF) is the most common cyanotic congenital heart disease (19). The main features include ventricular septum defect, subpulmonary stenosis, and overriding aorta and right ventricular (RV) hypertrophy. Surgical repair is usually performed in early infancy to widen the passage from the RV to the pulmonary artery and close the ventricular septal defect. This ensures separation of oxygen-rich and oxygenpoor blood flows to the proper chambers. Surgical repair of TOF often involves disruption of pulmonary valve integrity that leads to pulmonary regurgitation (PR; Refs. 8, 37). This in turn causes RV dilation (9, 23) and RV outflow tract (RVOT) aneurysm (2-3, 13, 28 -29). The RV dilation is usually tolerated with little or no symptoms during the first two to three decades of age. If left untreated, however, continued...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

See 1 more Smart Citation

Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot

Zhong

Gobeawan

et al. 2012

American Journal of Physiology-Heart and Circulatory Physiology

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the present study, we tested the feasibility of quantifying local, LV size normalized, 3D endocardial surface curvature to describe regional LV shape and to investigate regional differences in endocardial curvature in normal and hypokinetic ventricles [17]. The potential usefulness of this approach for characterizing changes in LV shape in patients with DCM has been recently demonstrated in the context of the evaluation of the extent of scar in patients with ischemic DCM [18].…”

Section: Discussionmentioning

confidence: 99%

“…Initial testing of curvature analysis in a small number of patients from CMR images [17,18] had demonstrated its feasibility and yielded promising results that warrant further testing and validation in larger groups of patients. Accordingly, the aims of this study were (a) to determine normal patterns of regional endocardial curvature and its changes throughout the cardiac cycle by analyzing CMR images obtained in patients with normal LV wall motion and (b) to test this technique on images obtained in patients with global and regional hypokinesis, in order to understand the effects of these conditions on regional LV shape.…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional analysis of regional left ventricular endocardial curvature from cardiac magnetic resonance images

Maffessanti

Lang

Niel

et al. 2011

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: Left ventricular (LV) remodeling is usually assessed using global changes in LV volume. We hypothesized that threedimensional analysis of regional endocardial curvature from magnetic resonance images could provide clinically useful information on localized LV remodeling. We tested this approach by investigating regional differences in endocardial curvature in normal and hypokinetic ventricles. Materials and Methods: Images were obtained in 44 patients with normal LV function (NL, N=14), dilated cardiomyopathy (DCM, N=15) or ischemic heart disease (IHD, N=15). Local surface curvedness, normalized to take into account instantaneous LV size (C n ), was calculated throughout the cardiac cycle and compared between segment groups: NL (N=401), IHD (N=92) and DCM (N=255). Results: In all normal segments, C n gradually increased during systole and then decreased during diastole. While both maximum and minimum values of C n were comparable in the basal and midventricular segments, they were significantly higher in the four apical segments and highest in the apical cap. In addition, percent change in C n was higher in mid and apical compared to basal segments (Pb.05). At all LV levels, C n values in DCM segments were lower (Pb.05) than in NL and IHD segments, which were similar. In contrast, percent change in C n was significantly lower in both IHD and DCM segments compared to NL. Conclusion: Three-dimensional analysis of LV endocardial curvature yielded quantitative information on regional ventricular shape consistent with the known pathophysiology, supporting its potential clinical usefulness in the evaluation of LV remodeling.

show abstract

Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology

et al. 2023

View full text Add to dashboard Cite

Myocardial infarction (MI) is one of the leading causes of death and disability. Recently developed cardiac patches provide mechanical support and additional conductive paths to promote electrical signal propagation in the MI area to synchronize cardiac excitation and contraction. Cardiac patches based on conductive polymers offer attractive features; however, the modest levels of elasticity and high impedance interfaces limit their mechanical and electrical performance. These structures also operate as permanent implants, even in cases where their utility is limited to the healing period of tissue damaged by the MI. The work presented here introduces a highly conductive cardiac patch that combines bioresorbable metals and polymers together in a hybrid material structure configured in a thin serpentine geometry that yields elastic mechanical properties. Finite element analysis guides optimized choices of layouts in these systems. Regular and synchronous contraction of human induced pluripotent stem cell‐derived cardiomyocytes on the cardiac patch and ex vivo studies offer insights into the essential properties and the bio‐interface. These results provide additional options in the design of cardiac patches to treat MI and other cardiac disorders.

show abstract

A curvature-based approach for left ventricular shape analysis from cardiac magnetic resonance imaging

Cited by 25 publications

References 35 publications

Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot

Right ventricular regional wall curvedness and area strain in patients with repaired tetralogy of Fallot

Three-dimensional analysis of regional left ventricular endocardial curvature from cardiac magnetic resonance images

Materials and Design Approaches for a Fully Bioresorbable, Electrically Conductive and Mechanically Compliant Cardiac Patch Technology

Contact Info

Product

Resources

About