A current perspective on the relevance of nano and microplastics in the neurodevelopmental disorders: further relevance for metabolic, gastrointestinal, oxidative stress-related and zebrafish studies

Abstract

Modern world is relying more and more on the use of plastics in order to conduct our daily tasks going from the simple lid that covers our morning coffee to large scale use in packaging and buildings. But how does the use of so much plastic influence human's normal growth and development or more importantly, how does it affect the brain functions? For the purpose of this paper of giving a little literature insight over the toxic effects of micro-/nanoplastics we chose to approach it from a multidisciplinary point of view with a focus on the use of zebrafish as animal models; ranging from how microplastics disrupts the host eubiosis and

Current Aspects on the Plastic Nano- and Microparticles Toxicity in Zebrafish—Focus on the Correlation between Oxidative Stress Responses and Neurodevelopment

“…However, further studies regarding these aspects are needed, as the patterns were shown to be dependent on the type, size, and doses of plastic particles used in exposure. Also, the molecular mechanisms underlying the behavioral impairments and their correlation with OS mechanisms could be further studied in the context of plastic NPs/MPs intoxication, since the correlation between two out of the three components of this multifactorial interaction has already described [9,[32][33][34][35][36][37][38][39][40].…”

“…Despite the fact that the zebrafish brain is less complex than rodent and human brains, it is a major source of reactive oxygen species and is thus the most susceptible tissue to oxidative stress damage, one of the most common preserved traits. The effects of OS on the cerebral tissues and central nervous system were previously extensively discussed by our group while describing new pathophysiological patterns or bringing additional evidence to support the emergent OS pathological hypothesis in neurophysiology [9,[32][33][34][35][36][37][38][39][40]. In this context, the evaluation of enzymatic and non-enzymatic antioxidants and OS effects on cellular and molecular structures could be observed in zebrafish in a tissue-specific manner but is not restricted to it [41].…”