A Current Overview of Scaffold-Based Bone Regeneration Strategies with Dental Stem Cells

Ercal, Pınar; Peközer, Görke Gürel

doi:10.1007/5584_2020_505

Cited by 20 publications

(23 citation statements)

References 161 publications

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“…An enormous number of studies have been carried out to investigate the role of various scaffolds on the bone regeneration capacity of DSCs[ 137 ]. The osteogenic differentiation ability of DSCs, mostly isolated from dental pulp or periodontal ligament, has been well demonstrated in both in vivo and in vitro studies[ 138 ].…”

Section: Bone Reconstructionmentioning

confidence: 99%

Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies

Granz

Gorji

2020

WJSC

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Dental stem cells (DSCs) are self-renewable cells that can be obtained easily from dental tissues, and are a desirable source of autologous stem cells. The use of DSCs for stem cell transplantation therapeutic approaches is attractive due to their simple isolation, high plasticity, immunomodulatory properties, and multipotential abilities. Using appropriate scaffolds loaded with favorable biomolecules, such as growth factors, and cytokines, can improve the proliferation, differentiation, migration, and functional capacity of DSCs and can optimize the cellular morphology to build tissue constructs for specific purposes. An enormous variety of scaffolds have been used for tissue engineering with DSCs. Of these, the scaffolds that particularly mimic tissue-specific micromilieu and loaded with biomolecules favorably regulate angiogenesis, cell-matrix interactions, degradation of extracellular matrix, organized matrix formation, and the mineralization abilities of DSCs in both in vitro and in vivo conditions. DSCs represent a promising cell source for tissue engineering, especially for tooth, bone, and neural tissue restoration. The purpose of the present review is to summarize the current developments in the major scaffolding approaches as crucial guidelines for tissue engineering using DSCs and compare their effects in tissue and organ regeneration.

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Section: Bone Reconstructionmentioning

confidence: 99%

Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies

Granz

Gorji

2020

WJSC

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“…In this context, the main purpose of regenerative medicine is to overcome the limit of the low regenerative power of tissues, creating strategies to restore their functionality and architecture. Tissue engineering denotes a novel approach to regenerative medicine in order to develop tissue-like complexes that mimic the role and structural organization of tissues in order to repair injuries, anatomical defects, and restore the functions of the damaged areas using biomaterials and stem cells [ 3 , 4 , 5 ]. Specifically, the differentiation capacity and the paracrine effects of stem cells, such as mesenchymal stem cells (MSCs), are useful for tissue regeneration, and their application seems promising in different fields of regenerative medicine, including bone regeneration [ 6 , 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Scaffolds are three-dimensional structures that promote the reconstruction of tissue architecture. The scaffold is made of a biomaterial that provides a template to ameliorate the healing process and to promote cell attachment, proliferation, differentiation, and extracellular matrix (ECM) generation [ 5 , 9 ]. Obviously, scaffolds need to show physical features that allow for oxygen and nutrient transport, the maintenance of cell survival, and the promotion of cell differentiation and homing in order to allow for MSC growth.…”

Section: Introductionmentioning

confidence: 99%

Oral Bone Tissue Regeneration: Mesenchymal Stem Cells, Secretome, and Biomaterials

Gugliandolo

Fonticoli

Trubiani

et al. 2021

IJMS

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In the last few decades, tissue engineering has become one of the most studied medical fields. Even if bone shows self-remodeling properties, in some cases, due to injuries or anomalies, bone regeneration can be required. In particular, oral bone regeneration is needed in the dentistry field, where the functional restoration of tissues near the tooth represents a limit for many dental implants. In this context, the application of biomaterials and mesenchymal stem cells (MSCs) appears promising for bone regeneration. This review focused on in vivo studies that evaluated bone regeneration using biomaterials with MSCs. Different biocompatible biomaterials were enriched with MSCs from different sources. These constructs showed an enhanced bone regenerative power in in vivo models. However, we discussed also a future perspective in tissue engineering using the MSC secretome, namely the conditioned medium and extracellular vesicles. This new approach has already shown promising results for bone tissue regeneration in experimental models.

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“…Ceramics can be divided into two categories: bioinert and bioactive. The bioinert ceramics, such as alumina and zirconia, induce immunoreaction and can form a thin fibrous layer at the bone interface (Ercal and Pekozer, 2020). Therefore, bioinert ceramics are not considered a usable material for bridging bone defects.…”

Section: Inorganic Compound-based Ceramicsmentioning

confidence: 99%

“…However, the biodegradation rate of the β-TCP scaffolds is too fast to be compensated for by newly formed bone. Moreover, β-TCP scaffolds are brittle with a very low tensile strength (Ercal and Pekozer, 2020). Therefore, in order to counteract these drawbacks, other biomaterials are often mixed with β-TCP.…”

Section: Tricalcium Phosphate (Tcp): a Popularmentioning

confidence: 99%

Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine

Zhang

Zhao

et al. 2020

Front. Bioeng. Biotechnol.

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Bone is a dynamic organ with high regenerative potential and provides essential biological functions in the body, such as providing body mobility and protection of internal organs, regulating hematopoietic cell homeostasis, and serving as important mineral reservoir. Bone defects, which can be caused by trauma, cancer and bone disorders, pose formidable public health burdens. Even though autologous bone grafts, allografts, or xenografts have been used clinically, repairing large bone defects remains as a significant clinical challenge. Bone tissue engineering (BTE) emerged as a promising solution to overcome the limitations of autografts and allografts. Ideal bone tissue engineering is to induce bone regeneration through the synergistic integration of biomaterial scaffolds, bone progenitor cells, and bone-forming factors. Successful stem cell-based BTE requires a combination of abundant mesenchymal progenitors with osteogenic potential, suitable biofactors to drive osteogenic differentiation, and cell-friendly scaffold biomaterials. Thus, the crux of BTE lies within the use of cell-friendly biomaterials as scaffolds to overcome extensive bone defects. In this review, we focus on the biocompatibility and cell-friendly features of commonly used scaffold materials, including inorganic compound-based ceramics, natural polymers, synthetic polymers, decellularized extracellular matrix, and in many cases, composite scaffolds using the above existing biomaterials. It is conceivable that combinations of bioactive materials, progenitor cells, growth factors, functionalization techniques, and biomimetic scaffold designs, along with 3D bioprinting technology, will unleash a new era of complex BTE scaffolds tailored to patient-specific applications.

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A Current Overview of Scaffold-Based Bone Regeneration Strategies with Dental Stem Cells

Cited by 20 publications

References 161 publications

Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies

Dental stem cells: The role of biomaterials and scaffolds in developing novel therapeutic strategies

Oral Bone Tissue Regeneration: Mesenchymal Stem Cells, Secretome, and Biomaterials

Stem Cell-Friendly Scaffold Biomaterials: Applications for Bone Tissue Engineering and Regenerative Medicine

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