A curious case of metastatic parotid adenoid cystic carcinoma to kidney

Abstract

A woman in her 60s presented with a 2-week history of non-specific left-sided abdominal pain. She previously underwent a total parotidectomy and adjuvant radiotherapy for left parotid adenoid cystic carcinoma 13 years prior, with a local recurrence 4 years after. Investigations revealed a large left-sided renal mass with appearances of renal carcinoma and no signs of metastatic disease. Pathology following nephrectomy revealed a metastatic adenoid cystic carcinoma.Metastatic disease recurred 11 months postradical nephrectomy to the contralateral kidney and lung, and she was referred to medical oncology for further management.This case history demonstrates the highly aggressive nature of an adenoid cystic carcinoma primary of salivary gland origin with rare metastasis to the kidney.

A rare case of bilateral renal metastases arising from minor salivary gland adenoid cystic carcinoma

“…One year after the primary nephrectomy the patient had a recurrence in the contralateral kidney. 3 In the present case the bilateral renal metastases were homogeneous, smaller, and appeared closer to the primary diagnosis, and the AdCC originated from a minor salivary gland.…”

“… 1 , 2 Renal metastases, as in the present case, are rare. 2 , 3 , 4 To our knowledge, only a few cases have been reported, none of which included bilateral renal metastases at the time of discovery or biopsy-verified AdCC metastases prior to treatment decision-making. 3 , 4 …”

“…The most similar case reported was a case of metastatic parotid AdCC to the kidney 13 years after the primary diagnosis. 3 On CT, the renal mass was heterogeneous and lobulated with a diameter of up to 10 cm. One year after the primary nephrectomy the patient had a recurrence in the contralateral kidney.…”

“… 1 Salivary gland AdCC has a tendency for recurrence, and distant metastases are not uncommon, but renal metastases are rare. 1 , 2 , 3 , 4 Recurrent and/or metastatic salivary gland AdCC has an overall survival rate of 40% at 10 years. 1 We report a case of bilateral renal metastases from salivary gland AdCC.…”