A Cumulative Impact of Psychological and Sensitization Risk Factors on Pain‐Related Outcomes

Uddin, Zakir; Woznowski-Vu, Arthur; Flegg, Daniel; Aternali, Andrea; Wideman, Timothy H.

doi:10.1111/papr.12987

Cited by 10 publications

(10 citation statements)

References 92 publications

(125 reference statements)

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“…Namely, a subgroup with a combination of a high PCS score and a low PPT were most vulnerable in terms of pain rehabilitation outcomes (ie, this subgroup had the highest level of clinical pain intensity, disability, and self-reported physical interference). 58 The present work extends the relationship between sensitivity to pain and catastrophizing by showing that catastrophizing has a role as a mediator trait between personality traits and pain sensitivity. Namely, catastrophizing was found to mediate between neuroticism and sensitivity to pain in two approaches for assessing pain sensitivity.…”

Section: Discussionsupporting

confidence: 63%

More Insight on the Role of Personality Traits and Sensitivity to Experimental Pain

Grouper¹,

Eisenberg²,

Pud³

2021

JPR

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Purpose The present study aimed to assess the influence of personality traits on the variability of sensitivity to pain in two distinct groups of healthy subjects with low versus high sensitivity to pain (LSP vs HSP, respectively). Methods Healthy subjects (n=156) were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (n=76) reached the cut-off time of 180±0 sec, and a size matched group of HSP (n=80) tolerated the CPT for an average of 10.5±3.4 sec only. Subjects from both groups completed the self-reported pain sensitivity questionnaire (PSQ), the Pain Catastrophizing Scale (PCS), and the Neuroticism Extraversion Openness - Five Factor Inventory (NEO-FFI). Results In comparison to the LSP group, HSP individuals had higher scores of PSQ ( p <0.001), catastrophizing ( p =0.001), and extraversion ( p =0.01). By adjusting for age and gender, mediation analyses revealed that catastrophizing mediated the relationship between neuroticism and pain sensitivity, both in the allocation of subjects to a certain group of sensitivity to pain (LSP or HSP, B=0.02 95% CI: 0.006–0.040) and in the PSQ score (B=0.01 95% CI: 0.001–0.023). Conclusion These results, which were demonstrated by two different prisms (CPT and PSQ), point to the potential of the five-factor inventory and pain catastrophizing scale as tools for identifying specific personality traits associated with a high sensitivity to pain.

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Section: Discussionsupporting

confidence: 63%

More Insight on the Role of Personality Traits and Sensitivity to Experimental Pain

Grouper¹,

Eisenberg²,

Pud³

2021

JPR

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“…This is in line with previous studies that concluded that not only does trait anxiety have an excitatory effect on pain and vice versa, it also contributes to the intensity of experienced pain [ 56 , 59 , 60 ]. To summarize, our finding that both lower PPTs and high anxiety levels predict MEP is supported by another study that found a cumulative impact of psychological and sensitization risk factors (i.e., high pressure sensitivity measured by PPT) on pain-related outcomes [ 61 ].…”

Section: Discussionsupporting

confidence: 71%

Susceptibility to movement-evoked pain following resistance exercise

et al. 2022

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Objective To investigate the: (1) role of basic muscle pain sensitivity and psychological factors in the prediction of movement-evoked pain (MEP) following delayed onset muscle soreness (DOMS), and (2) association of MEP with changes in systemic muscle pain sensitivity following DOMS induction. Methods Fifty-one participants were assigned to either eccentric resistance exercise or control groups. They completed questionnaires evaluating psychological distress and underwent muscle pain sensitivity evaluation by the pressure pain threshold (PPT) test at the exercised and remote muscles, before and 24 hours following the intervention. MEP intensity was determined in response to lifting a 3kg canister using a visual analogue scale (VAS). Results The exercise group demonstrated MEP intensity of 5/10 on VAS and reduced PPTs at the main exercised muscle (p<0.001). A regression tree analyses revealed that the level of anxiety trait predicted a higher MEP intensity. A secondary analysis showed that 53% participants who were DOMS responders (MEP > mild intensity; ≥ 3/10 VAS) exhibited decreased PPTs in the exercised (p<0.001) and remote (p = 0.027) muscles following eccentric exercise. Characterization of DOMS responders revealed that, at baseline, they had lower PPTs in the exercised (p = 0.004) and remote (p = 0.001) muscles and reported higher psychological distress i.e., anxiety trait and depression symptoms (p<0.05), compared to non-responders. A regression analysis revealed that lower PPT or high levels of anxiety trait increased the probability to become a responder (p = 0.001). Conclusions Susceptibility to MEP following DOMS is determined by muscle pain hypersensitivity and high levels of anxiety trait. MEP at the early stage of DOMS is linked with an increase in systemic muscle pain sensitivity suggestive of central mechanisms. This knowledge is valuable in translating science into clinical musculoskeletal pain management.

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“…The physical and affective factor's items of BPI are supported by confirmatory factor and Rasch analysis ( 19 , 20 ). Pain interference types (affective and physical) are helpful to guide clinical assessment in pain conditions ( 21 – 23 ). The BPI is widely used for people living with pain and is recommended for pain-related outcome measures ( 18 – 21 , 24 – 26 ).…”

Section: Methodsmentioning

confidence: 99%

Combined Effect of Vitamin D Supplementation and Physiotherapy on Reducing Pain Among Adult Patients With Musculoskeletal Disorders: A Quasi-Experimental Clinical Trial

Ali¹,

Uddin

Hossain

2021

Front. Nutr.

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Background: The prevalence of musculoskeletal disorders (MSD) and vitamin D insufficiency is high. Past research indicating vitamin D supplementation and physiotherapy are useful for the treatment of MSDs. However, to the best of our knowledge, the combined benefits of vitamin D and physiotherapy are not yet evaluated in MSD. We hypothesized that combined intervention of vitamin D supplementation and physiotherapy would be more effective in relieving the pain of MSD compared to only physiotherapy intervention.Objective: This study aimed to examine whether combined effect of vitamin D supplementation and physiotherapy was better than physiotherapy alone in reducing pain-related outcomes (e.g., pain severity, affective interference, and physical interference) in patients with MSD.Methods: A quasi-clinical experiment was conducted between May 2020 and April 2021. Vitamin D level in the blood was measured at the start of the study. Patients with vitamin D levels <20 ng/mL were assigned to the combined physiotherapy and vitamin D group. The physiotherapy group consisted of the patients with vitamin D levels more than 20 ng/mL. The Brief Pain Inventory scale was utilized to measure pain at baseline and after 12 weeks of interventions. We used the paired t-tests for unadjusted analysis. Further, a linear regression model was used to identify the combined effect of physiotherapy and vitamin D on reducing pain scores after adjusting potential confounders.Results: Combined intervention of vitamin D and physiotherapy showed significantly better results than only physiotherapy intervention in the reduction of three pain-related outcomes (p < 0.001). The multivariable analysis indicated that the combination of physiotherapy and vitamin D treatment reduced pain score by 1.126 (slope = −1.126, p = 0.035) compared to physiotherapy alone.Conclusion: Combined intervention (vitamin D with physiotherapy) had a better pain-relieving effect than physiotherapy alone. To confirm these findings, more research is needed with randomized control trials.Clinical Trial Registration: [http://ctri.nic.in/Clinicaltrials/advancesearchmain.php], identifier [CTRI/2020/04/024845].

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A Cumulative Impact of Psychological and Sensitization Risk Factors on Pain‐Related Outcomes

Cited by 10 publications

References 92 publications

More Insight on the Role of Personality Traits and Sensitivity to Experimental Pain

More Insight on the Role of Personality Traits and Sensitivity to Experimental Pain

Susceptibility to movement-evoked pain following resistance exercise

Combined Effect of Vitamin D Supplementation and Physiotherapy on Reducing Pain Among Adult Patients With Musculoskeletal Disorders: A Quasi-Experimental Clinical Trial

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