A Cultured Skin Substitute Composed of Fibroblasts and Keratinocytes with a Collagen Matrix: Preliminary Results of Clinical Trials

Yoshimitsu, Kengo; Kenmochi, Makoto; Ishihara, Shuichi; Takeda, Akiko; Shiraishi, Akihiko; Ootake, Naoyuki; Uchinuma, Eijyu; Torikai, Katsuyukí; Shioya, Nobuyuki

doi:10.1097/00000637-199310000-00011

Cited by 57 publications

(14 citation statements)

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“…These constructs could be combined with overlying keratinocyte sheets and transplanted in vivo , producing architectural structures similar to normal skin. Early clinical reports utilizing cellularized dermal equivalents reported positive results, but larger clinical studies remain lacking .…”

Section: Future Perspectivesmentioning

confidence: 99%

Tissue engineering for the management of chronic wounds: current concepts and future perspectives

Wong

Gurtner

2012

Experimental Dermatology

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Chronic wounds constitute a significant and growing biomedical burden. With the increasing growth of populations prone to dysfunctional wound healing, there is an urgent and unmet need for novel strategies to both prevent and treat these complications. Tissue engineering offers the potential to create functional skin, and the synergistic efforts of biomedical engineers, material scientists, and molecular and cell biologists have yielded promising therapies for non-healing wounds. However, traditional paradigms for wound healing focus largely on the role of inflammatory cells and fail to incorporate more recent research highlighting the importance of stem cells and matrix dynamics in skin repair. Approaches to chronic wound healing centred on inflammation alone are inadequate to guide the development of regenerative medicine-based technologies. As the molecular pathways and biologic defects underlying non-healing wounds are further elucidated, multifaceted bioengineering systems must advance in parallel to exploit this knowledge. In this viewpoint essay, we highlight the current concepts in tissue engineering for chronic wounds and speculate on areas for future research in this increasingly interdisciplinary field.

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Section: Future Perspectivesmentioning

confidence: 99%

Tissue engineering for the management of chronic wounds: current concepts and future perspectives

Wong

Gurtner

2012

Experimental Dermatology

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“…Currently, vascularisation of neo-structures is solved by microvascular techniques, while bony chest structure replacement requires a combined work with orthopaedics. Chest-wall defects -following tumour resection or due to extensive trauma -are additional fields of tissue engineering that require collaborative research work in several disciplines [63][64][65]. Artificial coverage or neogenesis of injured or destroyed pleural surfaces has an intense clinical priority but is neglected by basic research, highlighting the need for better communication between basic and clinical sciences.…”

Section: Chest-wall Structures and Pleural Surfacesmentioning

confidence: 99%

Tissue engineering and biotechnology in general thoracic surgery

Molnár

Pongrácz

2010

European Journal of Cardio-Thoracic Surgery

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Public interest in the recent progress of tissue engineering, a special line of biotechnology, makes the current review on thoracic surgery highly relevant. In this article, techniques, materials and cellular processes are discussed alongside their potential applications in tissue repair. Different applications of tissue engineering in tracheo-bronchial replacement, lung tissue cultures and chest-wall reconstruction are also summarised in the article. Potential tissue engineering-based solutions for destructive, chronic lung-injury-related conditions and replacement of tubular structures in the central airways are also examined.

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“…Kuroyanagi et al 67 developed an autologous CSS that was prepared through the successive cultivation of autologous fibroblasts and keratinocytes that were plated on each surface of spongy collagen. According to this technique, allogeneic CDS composed of a spongy collagen containing allogeneic fibroblasts was developed.…”

Section: New Wound Dressings With Biologically Active Substancesmentioning

confidence: 99%