A csanádi székeskáptalan személyi összetétele a késő-középkorban (1354-1526)

Tóth, Péter G.

doi:10.14232/phd.2528

Cited by 4 publications

(47 citation statements)

References 1 publication

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“…[27] To meet this requirement, a P. chrysogenum-based expression system was developed for the optimal bulk production of PAF, [46] PAFB, [28] and NFAP2. [50] This system is reliable considering the correct protein processing, folding, and disulfide bond formation. [46,50] Applying P. chrysogenum as expression host, crAFPs do not undergo any posttranslational modifications, except for the required cleavage of the prepro-sequence ( Figure 1) and folding.…”

Section: Recombinant Productionmentioning

confidence: 99%

“…[27,57,58,59] As for anti-Candida activity, the co-administration of NFAP2 and fluconazole in standardized clinical microbiological susceptibility tests inhibited the in vitro growth of C. albicans and C. parapsilosis in a synergistic way, but was neutral against C. krusei. [50] The applicability of crAFPs in vivo was further shown in a mouse infection model, where the synergistic anti-Candida efficacy of NFAP2 in combination with fluconazole was proven recently. [60] In contrast, no antagonistic mode of actions have been observed so far, which underlines the potential of crAFPs for anti-Candida polytherapy.…”

Section: Anti-candida Activity In Drug Combinationmentioning

confidence: 99%

“…Species MIC (mM) NFAP2 [50] PAF [ *The MIC of the synthetic PAF-derived g-core peptides on NACs was determined as described. [26] n.d.: not determined .…”

Section: Number Of Lys/arg/ Hismentioning

confidence: 99%

“…NMR investigations of NFAP2 are in progress. [50] These proteins have an amphipathic surface with alternating positively-and negatively-charged patches (Figure 3). It is assumed that apart from the correct disulfide bonding between the Cys residues, a 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 hidden central hydrophobic core coordinates the proper folding and the formation of a stable protein structure.…”

Section: Protein Structurementioning

confidence: 99%

“…[50] This system is reliable considering the correct protein processing, folding, and disulfide bond formation. [46,50] Applying P. chrysogenum as expression host, crAFPs do not undergo any posttranslational modifications, except for the required cleavage of the prepro-sequence ( Figure 1) and folding. This recently reported system represents the perfect tool for cost-effective generation of crAFPs in high yields.…”

Section: Recombinant Productionmentioning

confidence: 99%

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Cysteine‐Rich Antifungal Proteins from Filamentous Fungi are Promising Bioactive Natural Compounds in Anti‐Candida Therapy

Galgóczy

Yap

Marx

2019

Israel Journal of Chemistry

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The emerging number of life‐threatening invasive fungal infections caused by drug‐resistant Candida strains urges the need for the development and application of fundamentally new and safe antifungal strategies in the clinical treatment. Recent studies demonstrated that the extracellular cysteine‐rich and cationic antifungal proteins (crAFPs) originating from filamentous fungi, and de novo designed synthetic peptide derivatives of these crAFPs provide a feasible basis for this approach. This mini‐review focuses on the global challenges of the anti‐Canidia therapy and on the crAFPs as potential drug candidates to overcome existing problems. The advantages and limitations in the use of crAFPs and peptide derivatives compared to those of conventional antifungal drugs will also be critically discussed.

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Section: Recombinant Productionmentioning

confidence: 99%

Section: Anti-candida Activity In Drug Combinationmentioning

confidence: 99%

“…Species MIC (mM) NFAP2 [50] PAF [ *The MIC of the synthetic PAF-derived g-core peptides on NACs was determined as described. [26] n.d.: not determined .…”

Section: Number Of Lys/arg/ Hismentioning

confidence: 99%

Section: Protein Structurementioning

confidence: 99%

Section: Recombinant Productionmentioning

confidence: 99%

See 3 more Smart Citations

Cysteine‐Rich Antifungal Proteins from Filamentous Fungi are Promising Bioactive Natural Compounds in Anti‐Candida Therapy

Galgóczy

Yap

Marx

2019

Israel Journal of Chemistry

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Phase-field modeling of crystal nucleation in undercooled liquids – A review

Gránásy

Tóth

Warren

et al. 2019

Progress in Materials Science

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We review how phase-field models contributed to the understanding of various aspects of crystal nucleation including homogeneous and heterogeneous processes, and their role in microstructure evolution. We recall results obtained both by the conventional phase-field approaches that rely on spatially averaged (coarse grained) order parameters in capturing freezing, and by the recently developed phase-field crystal models that work on the molecular scale, while employing time averaged particle densities, and are regarded as simple dynamical density functional theories of classical particles. Besides simpler cases of homogeneous and heterogeneous nucleation, phenomena addressed by these techniques include precursor assisted nucleation, nucleation in eutectic and phase separating systems, phase selection via competing nucleation processes, growth front nucleation (a process, in which grains of new orientations form at the solidification front) yielding crystal sheaves and spherulites, and transition between the growth controlled cellular and the nucleation dominated equiaxial solidification morphologies. * granasy.laszlo@wigner.mta.hu arXiv:1907.05732v1 [cond-mat.mtrl-sci] 12 Jul 2019 D. Discussion: Nucleation in coarse grained PF models 32 IV. Molecular scale phase-field models of crystallization 34 A. The Phase-Field Crystal approach 34 1. The single-mode PFC model 34 2. The two-mode PFC model 35 3. The multi-mode PFC model 36 4. Other advanced PFC models 36 B. Application of the PFC models to crystal nucleation 37 1. Euler-Lagrange equation and other methods to find free energy extrema 37 2. PFC with diffusive dynamics (DPFC) 39 3. Hydrodynamic PFC model of freezing (HPFC) 46 4. Numerical methods 49 C.

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Heterogeneous nucleation of/on nanoparticles: a density functional study using the phase-field crystal model

et al. 2014

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Crystallization of supersaturated liquids usually starts by heterogeneous nucleation. Mounting evidence shows that even homogeneous nucleation in simple liquids takes place in two steps; first a dense amorphous precursor forms, and the crystalline phase appears via heterogeneous nucleation in/on the precursor cluster. Herein, we review recent results by a simple dynamical density functional theory, the phase-field crystal model, for (precursor-mediated) homogeneous and heterogeneous nucleation of nanocrystals. It will be shown that the mismatch between the lattice constants of the nucleating crystal and the substrate plays a decisive role in determining the contact angle and nucleation barrier, which were found to be non-monotonic functions of the lattice mismatch. Time dependent studies are essential as investigations based on equilibrium properties often cannot identify the preferred nucleation pathways. Modeling of these phenomena is essential for designing materials on the basis of controlled nucleation and/or nano-patterning.

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A csanádi székeskáptalan személyi összetétele a késő-középkorban (1354-1526)

Cited by 4 publications

References 1 publication

Cysteine‐Rich Antifungal Proteins from Filamentous Fungi are Promising Bioactive Natural Compounds in Anti‐Candida Therapy

Cysteine‐Rich Antifungal Proteins from Filamentous Fungi are Promising Bioactive Natural Compounds in Anti‐Candida Therapy

Phase-field modeling of crystal nucleation in undercooled liquids – A review

Heterogeneous nucleation of/on nanoparticles: a density functional study using the phase-field crystal model

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