A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer

Guz, Małgorzata; Jeleniewicz, Witold; Malm, Anna; Korona-Głowniak, Izabela

doi:10.3390/nu13072428

Cited by 19 publications

(17 citation statements)

References 205 publications

(237 reference statements)

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“…Deoxycholic acid promotes the development of CRC by downregulating miR-199a-5p, which acts as an anti-oncogenic miRNA, inhibiting the proliferation, migration, and invasion of colorectal cancer cells in vitro and in vivo indirectly through CAC1 protein. This protein interacts with CDK2, activating the cell cycle, and the loss of CAC1 properties leads to its arrest in the G1/S phase [ 117 , 118 ].…”

Section: Specific Microbial Metabolitesmentioning

confidence: 99%

The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis

Маркелова

Семенова

Sineva

et al. 2022

IJMS

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A number of bacteria that colonize the human body produce toxins and effectors that cause changes in the eukaryotic cell cycle—cyclomodulins and low-molecular-weight compounds such as butyrate, lactic acid, and secondary bile acids. Cyclomodulins and metabolites are necessary for bacteria as adaptation factors—which are influenced by direct selection—to the ecological niches of the host. In the process of establishing two-way communication with the macroorganism, these compounds cause limited damage to the host, despite their ability to disrupt key processes in eukaryotic cells, which can lead to pathological changes. Possible negative consequences of cyclomodulin and metabolite actions include their potential role in carcinogenesis, in particular, with the ability to cause DNA damage, increase genome instability, and interfere with cancer-associated regulatory pathways. In this review, we aim to examine cyclomodulins and bacterial metabolites as important factors in bacterial survival and interaction with the host organism to show their heterogeneous effect on oncogenesis depending on the surrounding microenvironment, pathological conditions, and host genetic background.

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Section: Specific Microbial Metabolitesmentioning

confidence: 99%

The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis

Маркелова

Семенова

Sineva

et al. 2022

IJMS

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“…Additionally, it was evidenced that imbalances in intestinal microbiota due to diet may contribute to the development of different pathologies by impairing the expression of miRNAs [ 62 ]. Accordingly, a poor diet quality was associated with a higher risk of mild cognitive impairment, which could have been mediated by microbiota composition (abundance of Proteobacteria and Gammaproteobacteria) and miRNA expression (hsa-let-7g-5p, hsa-miR-107, and hsa-miR-186-3p) in middle-aged and elderly Chinese population [ 63 ].…”

Section: Metagenomics Integrating Epigenomics Transcriptomics Proteom...mentioning

confidence: 99%

Holistic Integration of Omics Tools for Precision Nutrition in Health and Disease

2022

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The combination of multiple omics approaches has emerged as an innovative holistic scope to provide a more comprehensive view of the molecular and physiological events underlying human diseases (including obesity, dyslipidemias, fatty liver, insulin resistance, and inflammation), as well as for elucidating unique and specific metabolic phenotypes. These omics technologies include genomics (polymorphisms and other structural genetic variants), epigenomics (DNA methylation, histone modifications, long non-coding RNA, telomere length), metagenomics (gut microbiota composition, enterotypes), transcriptomics (RNA expression patterns), proteomics (protein quantities), and metabolomics (metabolite profiles), as well as interactions with dietary/nutritional factors. Although more evidence is still necessary, it is expected that the incorporation of integrative omics could be useful not only for risk prediction and early diagnosis but also for guiding tailored dietary treatments and prognosis schemes. Some challenges include ethical and regulatory issues, the lack of robust and reproducible results due to methodological aspects, the high cost of omics methodologies, and high-dimensional data analyses and interpretation. In this review, we provide examples of system biology studies using multi-omics methodologies to unravel novel insights into the mechanisms and pathways connecting the genotype to clinically relevant traits and therapy outcomes for precision nutrition applications in health and disease.

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“…To the best of our knowledge, butyrate produced by the gut microbiota provides approximately 70% of energy needs for the colonic epithelial cells. Aberrant expression of miRNAs can influence glucose metabolism mediated by butyrate in cancer cells through the gut-brain axis (16)(17)(18). Nonetheless, little is known of the potential interactions between miRNAs and gut microbiota in CRC glucose metabolic reprogramming.…”

Section: Regulation Of Glucose Metabolic Reprogramming By Mirnasmentioning

confidence: 99%

Emerging role of non-coding RNAs in glucose metabolic reprogramming and chemoresistance in colorectal cancer

Yan

Wang

et al. 2022

Front. Oncol.

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Metabolic reprogramming plays a critical role in colorectal cancer (CRC). It contributes to CRC by shaping metabolic phenotypes and causing uncontrolled proliferation of CRC cells. Glucose metabolic reprogramming is common in carcinogenesis and cancer progression. Growing evidence has implicated the modifying effects of non-coding RNAs (ncRNAs) in glucose metabolic reprogramming and chemoresistance in CRC. In this review, we have summarized currently published studies investigating the role of ncRNAs in glucose metabolic alterations and chemoresistance in CRC. Elucidating the interplay between ncRNAs and glucose metabolic reprogramming provides insight into exploring novel biomarkers for the diagnosis and prognosis prediction of CRC.

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A Crosstalk between Diet, Microbiome and microRNA in Epigenetic Regulation of Colorectal Cancer

Cited by 19 publications

References 205 publications

The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis

The Role of Cyclomodulins and Some Microbial Metabolites in Bacterial Microecology and Macroorganism Carcinogenesis

Holistic Integration of Omics Tools for Precision Nutrition in Health and Disease

Emerging role of non-coding RNAs in glucose metabolic reprogramming and chemoresistance in colorectal cancer

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