A cross-study meta-analysis and three-dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenic and bipolar brain

Todtenkopf, Mark S.; Vincent, Stephen L.; Beneš, Francine M.

doi:10.1016/j.schres.2004.08.018

Cited by 110 publications

(93 citation statements)

References 38 publications

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“…However, we speculate that loss of pyramidal neurons or their processes would likely to result in a reduction in both surface area and thickness, while the loss of nonpyramidal neurons (i.e., interneurons) and their processes with a mainly vertical organization would likely result in a reduction of thickness alone. A recent meta-analysis of post-mortem studies of the cingulate gyrus in individuals with schizophrenia found that both decreases in both pyramidal and non-pyramidal neurons and their processes is associated with schizophrenia (Todtenkopf, Vincent, and Benes, 2005). d. Probabilistic density functions for WM, GM and CSF.…”

Section: Discussionmentioning

confidence: 99%

“…Post-mortem studies of individuals with schizophrenia have revealed cellular abnormalities in the cingulate gyrus, especially its anterior segment (Benes, 1991,Benes and Bird, 1987,Benes, Vincent, and Todtenkopf, 2001,Chana et al, 2003,Dolan et al, 1995,Todtenkopf, Vincent, and Benes, 2005. The results of such studies suggest that reduced density of selected cell types in granular layers (Todtenkopf, Vincent, and Benes, 2005), reduced neuronal size (Bouras et al, 2001,Chana et al, 2003,Ongur, Drevets, and Price, 1998 and reduced glial density (Cotter et al, 2001) are features of the neuropathology of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

“…The results of such studies suggest that reduced density of selected cell types in granular layers (Todtenkopf, Vincent, and Benes, 2005), reduced neuronal size (Bouras et al, 2001,Chana et al, 2003,Ongur, Drevets, and Price, 1998 and reduced glial density (Cotter et al, 2001) are features of the neuropathology of schizophrenia. However, formulations of the pathogenesis of the schizophrenia, especially those that implicate N-methyl-D-aspartate (NMDA) receptor hypofunction (Olney and Farber, 1995) predict the presence of pathology across the entire anterior-to-posterior extent of the cingulate gyrus.…”

Section: Introductionmentioning

confidence: 99%

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Abnormalities of cingulate gyrus neuroanatomy in schizophrenia

Wang

Hosakere

Trein

et al. 2007

Schizophrenia Research

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Objective and Methods: Abnormalities of the neuroanatomy of the gray matter of the cingulate gyrus, especially its anterior segment, have been suggested to be an important characteristic of schizophrenia. In this study, T1-weighted magnetic resonance scans were collected in 53 individuals with schizophrenia and 68 comparison subjects matched for age, gender, race and parental socioeconomic status. We applied Labeled Cortical Mantle Distance Mapping to assess the volume, surface and thickness of the cortical mantle within the anterior (AC) and posterior (PC) segments of the cingulate gyrus, excluding the paracingulate gyrus, and related these anatomical measures to measures of psychopathology and illness duration. Results:After covarying for total cerebral volume, individuals with schizophrenia showed smaller AC gray matter volume (p=0.024), thickness (trend, p=0.081), but not surface area (p=0.16), than comparison subjects. Similar group differences were found for PC gray matter volume (p=0.0005) and thickness (trend, p=0.055), but not surface area (p=0.15). Across both groups, there was a significant L>R asymmetry in thickness of the AC, and a significant L>R asymmetry in the surface area of the PC. However, there were no significant group-by-hemisphere interactions. In the individuals with schizophrenia, thinning of the AC, but not the PC, was correlated with a longer duration of illness and a greater severity of psychotic symptoms.Conclusions: Individuals with schizophrenia showed smaller gray matter volumes across the entire cingulate gyrus, mostly due to a reduction in cortical mantle thickness. However, structural measures of the AC were more closely related to clinical features of the illness.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Abnormalities of cingulate gyrus neuroanatomy in schizophrenia

Wang

Hosakere

Trein

et al. 2007

Schizophrenia Research

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“…Postmortem studies of the ACC in SZ indicate numerous abnormalities (Todtenkopf et al, 2005;Oni-Orisan et al, 2008; for review see Fornito et al, 2009;Kraguljac et al, 2012a,b). Neurobiological differences between treatment response and treatment resistance in SZ are rarely studied in postmortem tissue, but provide a strategy for trying to link psychosis with particular neuropathology .…”

Section: Introductionmentioning

confidence: 99%

Synaptic Proteins in the Postmortem Anterior Cingulate Cortex in Schizophrenia: Relationship to Treatment and Treatment Response

Barksdale

Lahti

Roberts

2014

Neuropsychopharmacol

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The anterior cingulate cortex (ACC) is one of several brain regions that are abnormal in schizophrenia (SZ). Here we compared markers of synapse and mitochondrial function using western blots of postmortem ACC in: 1) normal controls (NCs, n ¼ 13) vs subjects with SZ (n ¼ 25); NC, treatment-resistant SZ, and treatment-responsive SZ; and 3) NC and SZ treated with typical or atypical antipsychotic drugs (APDs). Protein levels of synaptophysin, mitofusin-2, vGLUT1, and calcineurin did not differ between the NC and SZ group as a whole, or the NCs vs the SZ group divided by treatment response or type of APDs. In several cases, the levels of vGLUT1 were minuscule or absent. The proportion of NCs lacking vGLUT1 was significantly less than that of the SZ groups. There were several positive correlations across all subjects between: 1) synaptophysin and vGLUT1; 2) synaptophysin and calcineurin; 3) synaptophysin and mitofusin; and 4) calcineurin and mitofusin. Synaptophysin and calcineurin were positively correlated in responders, and this correlation was significantly stronger than that in treatment-resistant SZ subjects or in NCs. Synaptophysin and calcineurin were positively correlated in SZ patients on atypical APDs; this correlation was significantly stronger than that in SZ patients on typical APDs or in NCs. Mitofusin-2 and calcineurin were positively correlated in SZ patients on atypical APDs and in NCs; this correlation was stronger in SZ patients on atypical rather than typical APDs or in NCs. The correlation between these proteins, which have roles in synaptic vesicle cycling, glutamate transmission, mitochondrial fusion, and calcium buffering, is complex and was differentially regulated among the groups.

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“…To the extent that thinning of the cingulate gyrus is variable in its anatomical location across patients with schizophrenia, small differences in defining the anatomical boundaries of the cingulate gyrus could easily lead to differing results. While post-mortem studies of subjects with schizophrenia have been mostly confined to the anterior cingulate gyrus, the results of these studies suggest that thinning of the gray matter may be due to the loss of specific populations of interneurons and their processes (Todtenkopf et al, 2005). Taking these results together with our finding of variable thinning across the anterior-posterior extent of the cingulate and the known typology of connections across the cingulate gyrus, it suggests that populations of interneurons that function within neuroanatomical circuits represented across the cingulate gyrus may be especially vulnerable to the disease process associated with schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

Combining anatomical manifold information via diffeomorphic metric mappings for studying cortical thinning of the cingulate gyrus in schizophrenia

et al. 2007

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Spatial normalization is a crucial step in assessing patterns of neuroanatomical structure and function associated with health and disease. Errors that occur during spatial normalization can influence hypothesis testing due to the dimensionalities of mapping algorithms and anatomical manifolds (landmarks, curves, surfaces, volumes) used to drive the mapping algorithms. The primary aim of this paper is to improve statistical inference using multiple anatomical manifolds and Large Deformation Diffeomorphic Metric Mapping (LDDMM) algorithms. We propose that combining information generated by the various manifolds and algorithms improves the reliability of hypothesis testing. We used this unified approach to assess variation in the thickness of the cingulate gyrus in subjects with schizophrenia and healthy comparison subjects. Three different LDDMM algorithms for mapping landmarks, curves and triangulated meshes were used to transform thickness maps of the cingulate surfaces into an atlas coordinate system. We then tested for group differences by combining the information from the three types of anatomical manifolds and LDDMM mapping algorithms. The unified approach provided reliable statistical results and Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. HHS Public Access

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A cross-study meta-analysis and three-dimensional comparison of cell counting in the anterior cingulate cortex of schizophrenic and bipolar brain

Cited by 110 publications

References 38 publications

Abnormalities of cingulate gyrus neuroanatomy in schizophrenia

Abnormalities of cingulate gyrus neuroanatomy in schizophrenia

Synaptic Proteins in the Postmortem Anterior Cingulate Cortex in Schizophrenia: Relationship to Treatment and Treatment Response

Combining anatomical manifold information via diffeomorphic metric mappings for studying cortical thinning of the cingulate gyrus in schizophrenia

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