A Cross-Study Comparison of the Effects of Moclobemide and Brofaromine on Actual Driving Performance and Estimated Sleep

Ramaekers, Johannes G.; Veggel, Loe Ma van; O’Hanlon, John

doi:10.1097/00002826-199417001-00003

Cited by 21 publications

(21 citation statements)

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“…Disturbed sleep has been the most frequent sideeffect of the treatment of patients with major depression, panic disorder, and social phobia with the reversible MAOA inhibitor brofaromine and the irreversible inhibitor tranylcypromine, reported by as many as 53% (16,55,56). In addition, normal controls treated with brofaromine reported shorter sleep duration and lower sleep quality (57). In a polysomnographic study in depressed patients, the irreversible selective MAO-A inhibitor clorgyline nearly totally suppressed REM, significantly decreased total sleep time, and increased wake time during the night (58).…”

Section: Discussionmentioning

confidence: 99%

Associations of a Regulatory Polymorphism of Monoamine Oxidase-A Gene Promoter (MAOA-uVNTR) With Symptoms of Depression and Sleep Quality

Brummett

Krystal

Siegler

et al. 2007

Psychosomatic Medicine

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Objective-To examine the relationships among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality. The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. MAOA-uVNTR genotype has been associated with both psychological and physical measures.Methods-The sample consisted of 74 males enrolled in a case/control study of caregivers for relatives with dementia. Age-and race-adjusted linear regression models were used to examine the association between low versus high MAOA-uVNTR activity alleles, symptoms of depression (Center for Epidemiological Studies of Depression), and sleep quality ratings (Pittsburgh Sleep Quality Index).Results-MAOA-uVNTR alleles associated with less transcriptional activity were related to increased symptoms of depression (p < .04; Cohen's d = 0.52) and poorer sleep quality (p < .04; Cohen's d = 0.31).Conclusions-Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep.

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Section: Discussionmentioning

confidence: 99%

Associations of a Regulatory Polymorphism of Monoamine Oxidase-A Gene Promoter (MAOA-uVNTR) With Symptoms of Depression and Sleep Quality

Brummett

Krystal

Siegler

et al. 2007

Psychosomatic Medicine

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“…Fluoxetine belongs to a different class of Consequently, SSRIs are generally regarded as behavantidepressant drugs, the selective serotonin reuptake iorally safe drugs, whereas TCAs are classified as Though behavioral impairment depends primarily on the drug's intrinsic sedative activity, seen most clearly after initial doses, other factors such as pharmacological tolerance and accumulation can influence its persistence with repeated dosing. Tolerance to the sedative activity of antidepressants is generally recognized to diminish the acute impairing effects [1][2][3]. Accumulation occurs for most antidepressants when taken according to therapeutic dosing regimens.…”

Section: Introductionmentioning

confidence: 99%

“…Expectations based upon the studies mentioned above and similar studies with other TCAs and SSRIs [1,3,12,13] were as follows. We hypothesized that dothiepin would cause mild impairment on day 1, with attenuation of the effect on day 8 as a result of tolerance.…”

Section: Introductionmentioning

confidence: 99%

A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance.

Ramaekers

Muntjewerff

O’Hanlon

1995

Brit J Clinical Pharma

105

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“…Adaptation to the effects of TCAs on driving has, in fact, been demonstrated (Ramaekers et al, 1994;Robbe & O'Hanlon, 1995;van Laar et al, 1995).…”

Section: Behavioural Effectsmentioning

confidence: 99%

Prevention of relapse and recurrence of depression: newer versus older antidepressants

Edwards¹

1997

Adv. psychiatr. treat

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In a 17- to 19-year follow-up study it was shown that patients admitted to the Maudsley Hospital, London (whose index episode marked their first psychiatric contact) had a 50% chance of readmission during their lifetime; those with previous admissions had a similar chance of readmission within three years. Less than one-fifth of the patients had remained well, and over one-third suffered severe chronic distress and handicap or had died unnaturally (Lee & Murray, 1988). Similar gloomy pictures were reported in a 15-year follow-up study of patients in London and Sydney (Kilohet al, 1988) and an 11-year follow-up study of patients in Montreal (Lehmannet al, 1988). As a result of such findings, much emphasis is now put on the importance of continuation and maintenance treatment of depression.

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A Cross-Study Comparison of the Effects of Moclobemide and Brofaromine on Actual Driving Performance and Estimated Sleep

Cited by 21 publications

References 0 publications

Associations of a Regulatory Polymorphism of Monoamine Oxidase-A Gene Promoter (MAOA-uVNTR) With Symptoms of Depression and Sleep Quality

Associations of a Regulatory Polymorphism of Monoamine Oxidase-A Gene Promoter (MAOA-uVNTR) With Symptoms of Depression and Sleep Quality

A comparative study of acute and subchronic effects of dothiepin, fluoxetine and placebo on psychomotor and actual driving performance.

Prevention of relapse and recurrence of depression: newer versus older antidepressants

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