A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen

Hoare, Anilei; Wang, Hui; Meethil, Archana; Abusleme, Loreto; Hong, Bo Young; Moutsopoulos, Niki M.; Marsh, Philip; Hajishengallis, George; Diaz, Patricia I.

doi:10.1038/s41396-020-00865-y

Cited by 34 publications

(28 citation statements)

References 49 publications

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“…However, the enrichment of Veillonella parvula in CD is a novel finding. Indeed, V. parvula belongs to the genus Veillonella , considered a commensal found in the oral and intestinal tract, but which has occasionally been identified as a pathogen in cases of osteomyelitis [34] , meningitis [35] , and periodontitis [36] , and could therefore improve prediction models.…”

Section: Discussionmentioning

confidence: 99%

Dysbiosis and relapse-related microbiome in inflammatory bowel disease: A shotgun metagenomic approach

Serrano-Gómez

Mayorga

Oyarzun

et al. 2021

Computational and Structural Biotechnology Journal

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Section: Discussionmentioning

confidence: 99%

Dysbiosis and relapse-related microbiome in inflammatory bowel disease: A shotgun metagenomic approach

Serrano-Gómez

Mayorga

Oyarzun

et al. 2021

Computational and Structural Biotechnology Journal

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“… S. gordonii also impacts the pathogenicity of P. gingivalis through the secretion of para-aminobenzoic acid, which promotes in vivo fitness and colonization of P. gingivalis , albeit with diminished virulence ( 9 ). Additionally, V. parvula produces a soluble molecule that supports the growth of P. gingivalis from small populations, enabling in vivo colonization and virulence ( 10 ). Given recent bioinformatic research showing that the oral microbiome can produce an enormous number of small metabolites that may influence oral pathophysiology ( 11 ), many more metabolic interactions between oral microbes likely remain to be discovered.…”

Section: Introductionmentioning

confidence: 99%

Fusobacterium nucleatum Metabolically Integrates Commensals and Pathogens in Oral Biofilms

et al. 2022

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Periodontitis is caused by a pathogenic shift in subgingival biofilm ecosystems, which is accompanied by alterations in microbiome composition and function, including changes in the metabolic activity of the biofilm, which comprises multiple commensals and pathogens. While Fusobacterium nucleatum is a common constituent of the supra- and subgingival biofilms, its metabolic integration within polymicrobial communities and the impact on periodontal pathogenesis are poorly understood.

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“…Such a shift from mutualism to parasitism is more likely if the interaction is highly speci c, so that an organism is dependent on a single partner [37]. Bacteria within the densely packed dental plaque bio lm depend on one another for metabolites and signals [19,38,39], but the composition of oral microbial communities is characterized by wide uctuations in the relative abundance of taxa even as the overall community membership remains stable, a pattern known as stationary dynamics [40,41]. We observed exibility in the taxon relationships involved in corncobs, in the sense that several partners were capable of interacting with the central Corynebacterium lament and several streptococci could interact with the outer layer of Pasteurellaceae.…”

Section: Discussionmentioning

confidence: 99%

Corncob structures in dental plaque reveal microhabitat taxon specificity

Morillo-López

Sjaarda

Islam

et al. 2021

Preprint

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Background The human mouth is a natural laboratory for studying how bacterial communities differ across habitats. Different bacteria colonize different surfaces in the mouth – teeth, tongue dorsum, and keratinized and non-keratinized epithelia – despite the short physical distance between these habitats and their connection through saliva. We sought to determine whether more tightly defined microhabitats might have more tightly defined sets of resident bacteria. A microhabitat may be characterized, for example, as the space adjacent to a particular species of bacterium. Corncob structures of dental plaque, consisting of coccoid bacteria bound to filaments of Corynebacterium cells, present an opportunity to analyze the community structure of one such well-defined microhabitat within a complex natural biofilm. Here we investigate by fluorescence in situ hybridization and spectral imaging the composition of the cocci decorating the filaments. Results The range of taxa observed in corncobs was limited to a small subset of the taxa present in dental plaque. Among four major groups of dental plaque streptococci, two were the major constituents of corncobs, including one that was the most abundant Streptococcus species in corncobs despite being relatively rare in dental plaque overall. Images showed both Streptococcus types in corncobs in all individual donors, suggesting that the taxa possess different ecological roles or that mechanisms exist for stabilizing the persistence of functionally redundant taxa in the population. Direct taxon-taxon interactions were observed not only between the Streptococcus cells and the central corncob filament but also between Streptococcus cells and the limited subset of other plaque bacteria detected in the corncobs, indicating microhabitat specialization involving these taxa as well. Conclusions The spatial organization we observed in corncobs suggests that each of the microbial participants is capable of interacting with multiple, albeit limited, potential partners, a feature that may encourage the long-term stability of the community. Additionally, our results suggest the general principle that a precisely defined microhabitat will be inhabited by a small and well-defined set of microbial taxa.

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A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen

Abstract: This is a repository copy of A cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogen.

Cited by 34 publications

References 49 publications

Dysbiosis and relapse-related microbiome in inflammatory bowel disease: A shotgun metagenomic approach

Dysbiosis and relapse-related microbiome in inflammatory bowel disease: A shotgun metagenomic approach

Fusobacterium nucleatum Metabolically Integrates Commensals and Pathogens in Oral Biofilms

Corncob structures in dental plaque reveal microhabitat taxon specificity

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