A cross-sectional survey to investigate the prevalence of pain in Japanese patients with major depressive disorder and schizophrenia

Kishi, Taro; Matsuda, Yuki; Mukai, Tomohiko; Matsunaga, Satoru; Yasue, Ichiro; Fujita, Kiyoshi; Okochi, Tomo; Hirano, Shigeki; Kajio, Yusuke; Funahashi, Toshihiko; Akamatsu, Kaku; Ino, Kei; Okuda, Momoko; Tabuse, Hideaki; Iwata, Nakao

doi:10.1016/j.comppsych.2015.02.004

Cited by 14 publications

(11 citation statements)

References 14 publications

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“…In the present study, 61 of 100 MDD subjects reported having PPS, which is consistent with results from other studies (Ang et al, 2009;Agüera-Ortiz et al, 2011;Shimodera et al, 2012;Novick et al, 2013a;Kishi et al, 2015). In this study, no significant difference was observed in age and gender between the PPSþ and PPS-groups.…”

Section: Discussionsupporting

confidence: 94%

“…The presence of painful physical symptoms (PPS) associated with major depressive disorder (MDD) has recently received increased attention in the literature (Gerrits et al, 2015;Kishi et al, 2015;Bair et al, 2003). PPS in MDD are reported (Bair et al, 2003;Lee et al, 2009;Novick et al, 2013aNovick et al, , 2013bNovick et al, , 2015 to be very prevalent (50-76%), and are accompanied by more severe depressive symptoms and a poorer quality of life (Novick et al, 2013b(Novick et al, , 2015.…”

Section: Introductionmentioning

confidence: 98%

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Influence of painful physical symptoms in the treatment of Japanese patients with melancholic major depressive disorder: A prospective cohort study

Sekine¹,

Hozumi²,

Shimizu

2016

Psychiatry Research

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Section: Discussionsupporting

confidence: 94%

Section: Introductionmentioning

confidence: 98%

Influence of painful physical symptoms in the treatment of Japanese patients with melancholic major depressive disorder: A prospective cohort study

Sekine¹,

Hozumi²,

Shimizu

2016

Psychiatry Research

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“…Prevalence of PPS and its clinical importance have been increasingly recognized across Western countries and East Asia, including Japan. 1 – 3 …”

Section: Introductionmentioning

confidence: 99%

An observational study of duloxetine versus SSRI monotherapy for the treatment of painful physical symptoms in Japanese patients with major depressive disorder: primary analysis

Kuga

Tsuji

Hayashi

et al. 2017

NDT

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ObjectiveThe objective of this study was to assess the effectiveness of duloxetine monotherapy, in comparison with selective serotonin reuptake inhibitor (SSRI) monotherapy, in the treatment of painful physical symptoms (PPS) in Japanese patients with major depressive disorder (MDD) in real-world clinical settings.MethodsThis was a multicenter, 12-week prospective, observational study. This study enrolled MDD patients with at least moderate PPS, defined as a Brief Pain Inventory-Short Form (BPI-SF) average pain score (item 5) ≥3. Patients were treated with duloxetine or SSRIs (escitalopram, sertraline, paroxetine, or fluvoxamine) for 12 weeks, and PPS were assessed by BPI-SF average pain score. The primary outcome was early improvement in the BPI-SF average pain score at 4 weeks post-baseline.ResultsA total of 523 patients were evaluated for treatment effectiveness (duloxetine N=273, SSRIs N=250). The difference in BPI-SF average pain score between the two groups was not statistically significant at 4 weeks post-baseline, the primary endpoint (least-squares mean change from baseline [95% confidence interval]: duloxetine, −2.8 [−3.1, −2.6]; SSRIs, −2.5 [−2.8, −2.3]; P=0.166). There was a numerical advantage for duloxetine in improvement from 4 to 12 weeks post-baseline, and the difference was statistically significant at 8 weeks post-baseline (least-squares mean change from baseline [95% confidence interval]: duloxetine, −3.6 [−3.9, −3.3]; SSRIs, −3.1 [−3.4, −2.8]; P=0.023). The 30% and 50% responder rates were significantly higher in patients treated with duloxetine at 4 and 8 weeks post-baseline. There were no serious adverse events experienced by duloxetine-treated patients. The rate of discontinuations due to adverse events was similar for duloxetine and the SSRIs (1.0% and 0.8% of patients, respectively).ConclusionIn this observational study, BPI-SF improvement was not significantly different at 4 weeks, the primary endpoint; however, patients treated with duloxetine tended to show better improvement in PPS compared to those treated with SSRIs.

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“…Also, emotional states heavily influence pain (Villemure and Bushnell, 2009). The severity of psychopathology in patients with major depressive disorder was positively associated with the prevalence of pain (Kishi et al, 2015). Thus, pain is modulated by both sensory and emotional factors.…”

Section: Introductionmentioning

confidence: 99%

Astrocyte Activation in Locus Coeruleus Is Involved in Neuropathic Pain Exacerbation Mediated by Maternal Separation and Social Isolation Stress

et al. 2017

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Our previous studies demonstrated that emotional dysfunction associated with early life stress exacerbated nerve injury-induced mechanical allodynia. Sex differences were observed in several anxiety tests, but not in mechanical allodynia. To elucidate the mechanism underlying these findings, we have now investigated the involvement of astrocytes in emotional dysfunction and enhancement of nerve injury-induced mechanical allodynia in mice subjected to maternal separation combined with social isolation (MSSI) as an early life stress. We measured expression of glial fibrillary acidic protein (GFAP), an astrocyte maker, in each brain area by immunohistochemistry. GFAP expression in the locus coeruleus (LC) of female, but not of male mice, significantly increased after MSSI, corresponding to the behavioral changes at 7 and 12 weeks of age. Lipopolysaccharide (LPS)-treated astrocyte-derived supernatant was administered to local brain regions, including LC. Intra-LC injection of conditioned medium from cultured astrocytes treated with LPS increased GFAP expression, anxiety-like behavior and mechanical allodynia in both male and female mice. Furthermore, increases in anxiety-like behavior correlated with increased mechanical allodynia. These findings demonstrate that emotional dysfunction and enhanced nerve injury-induced mechanical allodynia after exposure to MSSI are mediated, at least in part, by astrocyte activation in the LC. Male but not female mice may show resistance to MSSI stress during growth.

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A cross-sectional survey to investigate the prevalence of pain in Japanese patients with major depressive disorder and schizophrenia

Cited by 14 publications

References 14 publications

Influence of painful physical symptoms in the treatment of Japanese patients with melancholic major depressive disorder: A prospective cohort study

Influence of painful physical symptoms in the treatment of Japanese patients with melancholic major depressive disorder: A prospective cohort study

An observational study of duloxetine versus SSRI monotherapy for the treatment of painful physical symptoms in Japanese patients with major depressive disorder: primary analysis

Astrocyte Activation in Locus Coeruleus Is Involved in Neuropathic Pain Exacerbation Mediated by Maternal Separation and Social Isolation Stress

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