A Cross-Sectional Survey of Severe Fever with Thrombocytopenia Syndrome Virus Infection of Domestic Animals in Laizhou City, Shandong Province, China

Ding, Shujun; Yin, Haiying; Xu, Xuehua; Liu, Guosheng; Jiang, Shanxiang; Wang, Weiqing; Han, X. B.; Liu, Jingyu; Niu, Guoyu; Zhang, Xiaomei; Yu, Xue Jie; Wang, Xianjun

doi:10.7883/yoken.67.1

Cited by 66 publications

(42 citation statements)

References 6 publications

(3 reference statements)

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“…This phenomenon indicated that ticks are most likely to be the vector of SFTSV [1, 4, 12]. Most patients were admitted to hospital from May to October.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the clinical and laboratory parameters of SFTS patients in China

Liu

Lei

2016

Virol J

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BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever in East Asia, which is caused by a novel bunyavirus-SFTSV. Many studies have reported the clinical characters of SFTS patients, but the reports were not consistent and a systematic summary of clinical manifestations and laboratory parameters are not available.MethodA comprehensive literature research of Web of Science, PubMed, Wan Fang Data, and Chinese National Knowledge Infrastructure databases was conducted on articles which have described the clinical characters of SFTS patients. Data from selected studies were pooled by using STATA VERSION 12.0 software.ResultNine articles comprising 844 laboratory-confirmed SFTSV cases were included in this meta-analysis. The pooled case fatality rate was 16% (95% CI: 0.13–0.19). The major clinical characters of patients with SFTSV infection were fever, thrombocytopenia, leucopenia, gastrointestinal symptoms, and central nervous system manifestations. The risk factors for severe disease included bleeding tendency, central nervous system manifestations, elevated serum enzymes, and high viral load. Although there is no specific antiviral therapy for SFTSV infection, symptomatic treatment and supportive therapy including intensive monitoring is the most essential part of case management.ConclusionThe major clinical characters of patients with SFTSV infection were fever, thrombocytopenia, leucopenia and gastrointestinal symptoms, and central nervous system manifestations. The risk factors for severity and fatality among SFTS patients included: old age, CNS manifestations, bleeding tendency, elevated serum enzymes, and high vial load.

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“…This phenomenon indicated that ticks are most likely to be the vector of SFTSV [1, 4, 12]. Most patients were admitted to hospital from May to October.…”

Section: Discussionmentioning

confidence: 99%

Meta-analysis of the clinical and laboratory parameters of SFTS patients in China

Liu

Lei

2016

Virol J

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“…However, the host range of the virus and the role of these animals in the transmission of SFTSV is poorly understood. [11, 12]. In addition, person to person transmission by contacting with infected patient’s blood or mucous has been reported in China [13–15].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis

Li¹,

Tong²,

Li³

et al. 2017

PLoS ONE

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ObjectiveSevere fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus-SFTSV. The seroprevalence of anti-SFTSV antibodies including immunoglobulin G (IgG) and immunoglobulin M (IgM), specific to SFTSV in the general population has been investigated in various epidemiological studies with inconsistent results. Here, we clarify this discrepancy and reach a more comprehensive result by mean of a meta-analysis.MethodsAll relevant articles were searched in the electronic databases (PubMed, Web of science, Embase, Chinese National Knowledge Infrastructure database, Chinese Wanfang database) up to November 2016. The pooled seroprevalence and 95% confidence intervals (95% CIs) were calculated by random- or fixed- model on the basis of heterogeneity.ResultsIn total, 21 studies containing 23,848 blood samples from 7 provinces were included in this meta-analysis. The minimum and maximum reported seroprevalences of SFTSV among humans in China were 0.23% and 9.17%, respectively. The overall pooled seroprevalence of SFTSV antibodies was 4.3% (95%CI: 3.2%-5.5%). The pooled prevalence was 5.9% (95%CI: 4.7%-7.0%) in Zhejiang province, 4.9% (95%CI: 4.1–5.8%) in Anhui province, 3.9% (95%CI: 1.3%-6.4%) in Shandong province, and 0.7% (95%CI: 0.2%-1.1%) in Jiangsu province. Stratified by occupation, the pooled prevalence of farmer was 6.1% (95%CI: 3.4%-8.9%) and others (mainly are students) was 3.3% (95%CI: 2.4%-4.2%). Additionally, seroprevalence of SFTSV in people who lived in the same village with the patient were higher than that of people who lived in a different village. Seropositive rates in sampling years after 2012 were higher than that before 2012. The prevalence of SFTSV did not differ by age or gender. Sensitive analysis by omitting one study at a time indicated the results of the pooled seroprevalence were robust.ConclusionsSeroprevalence of SFTSV among healthy population in central and eastern China is high. Surveillance efforts on mild or asymptomatic infections among endemic persons are needed.

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“…* indicates Fisher exact. against SFTSV has been observed in dogs, cattle, and other domestic animals in villages where the patients lived 1,[16][17][18] . The differences in the rates of SFTSV infections among various animal species and regions were statistically significant.…”

Section: Discussionmentioning

confidence: 99%

A Case-control Study of Risk Sources for Severe Fever with Thrombocytopenia Syndrome in Hubei Province, China

Xing

Guan

Liu

et al. 2017

International Journal of Infectious Diseases

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A Cross-Sectional Survey of Severe Fever with Thrombocytopenia Syndrome Virus Infection of Domestic Animals in Laizhou City, Shandong Province, China

Cited by 66 publications

References 6 publications

Meta-analysis of the clinical and laboratory parameters of SFTS patients in China

Meta-analysis of the clinical and laboratory parameters of SFTS patients in China

Seroprevalence of severe fever with thrombocytopenia syndrome virus in China: A systematic review and meta-analysis

A Case-control Study of Risk Sources for Severe Fever with Thrombocytopenia Syndrome in Hubei Province, China

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