A cross-sectional survey of cadmium biomarkers and cigarette smoking

Hecht, Eric M.; Arheart, Kristopher L.; Lee, David J; Hennekens, Charles H.; Hlaing, Way Way M.

doi:10.3109/1354750x.2016.1153717

Cited by 33 publications

(25 citation statements)

References 31 publications

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“…Additional interrelationships were also observed between cadmium biomarker levels and myocardial infarction and stroke [1, 2]. Our findings are compatible with earlier investigations [3-6].…”

Section: Introductionsupporting

confidence: 83%

Interrelationships of Cadmium, Smoking, and Angina in the National Health and Nutrition Examination Survey, a Cross-Sectional Study

et al. 2018

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The interrelationships between cadmium biomarker levels, smoking, and myocardial infarction and stroke have been established. In this cross-sectional analysis, we explored the interrelationships of blood cadmium levels, smoking, and angina. We analyzed the National Health and Nutrition Examination Survey (NHANES, 2003–2014) accounting for the multi-staged complex sampling design. Participants 40–79 years of age with blood cadmium levels but without a history of myocardial infarction and/or stroke were included (n = 14,832). We examined blood cadmium levels (3 tertile groups) in relation to 3 (diagnosed, undiagnosed, and composite diagnosed and/or undiagnosed) angina outcomes. Multivariable logistic regression models adjusted for age, diabetes, smoking status, and household income were used to estimate odds ratios (ORs) and their corresponding 95% confidence intervals (CIs). Of 14,832 participants, 741 (4.2%) had positive composite angina. The crude and adjusted ORs comparing those in the lowest tertile (referent group) of blood cadmium to those in the highest tertile for the composite outcome were 1.82 (95% CI 1.42–2.34) and 1.45 (95% CI 1.12–1.88), respectively. These cross-sectional data from a nationally representative sample contribute to the hypothesis that there are interrelationships between smoking, cadmium, and angina.

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Section: Introductionsupporting

confidence: 83%

Interrelationships of Cadmium, Smoking, and Angina in the National Health and Nutrition Examination Survey, a Cross-Sectional Study

et al. 2018

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“…19 Individual cigarettes contain around 1 mg of cadmium, of which about 35% is absorbed into the human bloodstream. 20 The half-life of cadmium is up to 15-20 years. 20 There are 2 forms of cadmium exposure.…”

Section: Question 2: What Toxins In Cigarette Smoke Lead To Cluster Hmentioning

confidence: 99%

“…20 The half-life of cadmium is up to 15-20 years. 20 There are 2 forms of cadmium exposure. Acute high dose exposure, which is typically from an occupational hazard, and chronic low dose exposure, which is typically from cigarette use.…”

Section: Question 2: What Toxins In Cigarette Smoke Lead To Cluster Hmentioning

confidence: 99%

“…19 Cigarette smoke is one of the primary sources of cadmium contact in humans. 20 The half-life of cadmium is up to 15-20 years. 20 The half-life of cadmium is up to 15-20 years.…”

mentioning

confidence: 99%

“…20,24,25 The National Health and Nutrition Examination Survey (NHANES) is an ongoing study of the US population. There are however several population based studies looking at cadmium levels in smokers that would include tobacco exposed CH patients.…”

mentioning

confidence: 99%

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Linking Cigarette Smoking/Tobacco Exposure and Cluster Headache: A Pathogenesis Theory

Rozen

2018

Headache

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The hypothesis theory will include several principles: (1) the need of double lifetime tobacco exposure, (2) that cadmium is possibly the primary agent in cigarette smoke that leads to hypothalamic-pituitary-gonadal axis toxicity promoting cluster headache, (3) that the estrogenization of the brain and its specific sexually dimorphic nuclei is necessary to develop cluster headache with tobacco exposure, and (4) that the chronic effects of smoking and its toxic metabolites including cadmium and nicotine on the cortex are contributing to the morphometric and orexin alterations that have been previously attributed to the primary headache disorder itself.

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Cadmium, obesity, and education, and the 10‐year incidence of hearing impairment: The beaver dam offspring study

et al. 2019

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Objectives/Hypothesis: To determine the 10-year incidence of hearing impairment (HI) and associated risk factors in the Beaver Dam Offspring Study (BOSS; 2004-present), a large middle-aged cohort followed for 10 years. ) follow-up examinations. HI was defined as a pure-tone average >25 dB HL in either ear. BOSS participants free of HI at baseline with at least one follow-up examination (N = 2,065) were included. Potential risk factors evaluated included cardiovascular measures, health history, lifestyle factors, inflammatory markers, vitamins D and B12, lead, and cadmium.Results: Participants were 21 to 79 years (mean age = 47.9 years) at baseline. The 10-year cumulative HI incidence was 17.4% (95% confidence interval [CI]: 15.7-19.2) and was twice as likely in men (24.4%, 95% CI: 21.5-27.7) than in women (12.2%, 95% CI: 10.3-14.3). In a multivariable adjusted model, age (hazard ratio [HR] = 1.48, 95% CI: 1.38-1.59, per 5 years), male sex (HR = 2.47, 95% CI: 1.91-3.18), less than a college education (HR = 1.35, 95% CI: 1.02-1.79), body mass index (HR = 1.03, 95% CI: 1.01-1.05, per kg/m 2 ), and higher cadmium levels (HR = 1.42, 95% CI: 1.05-1.92, quintile 5 vs. quintiles 1-4) were associated with the 10-year cumulative incidence of HI. There was no association between high lead levels, vitamins D or B12, and 10-year incidence of HI.Conclusions: In addition to age and sex, obesity, education, and blood cadmium levels were associated with increased incidence of HI. These prospective results add to evidence that age-related HI is a multifactorial preventable disorder.

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A cross-sectional survey of cadmium biomarkers and cigarette smoking

Cited by 33 publications

References 31 publications

Interrelationships of Cadmium, Smoking, and Angina in the National Health and Nutrition Examination Survey, a Cross-Sectional Study

Interrelationships of Cadmium, Smoking, and Angina in the National Health and Nutrition Examination Survey, a Cross-Sectional Study

Linking Cigarette Smoking/Tobacco Exposure and Cluster Headache: A Pathogenesis Theory

Cadmium, obesity, and education, and the 10‐year incidence of hearing impairment: The beaver dam offspring study

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