A cross-sectional study on the neurocognitive outcomes in vestibular impaired school-aged children: are they at higher risk for cognitive deficits?

Hecke, Ruth Van; Danneels, Maya; Deconinck, Frederik; Dhooge, Ingeborg; Leyssens, Laura; Acker, Emmely Van; Waelvelde, Hilde Van; Wiersema, Jan R.; Maes, Leen

doi:10.1007/s00415-023-11774-3

Cited by 2 publications

(4 citation statements)

References 52 publications

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“…Potential mild PVD in some healthy controls might have biased their results. Van Hecke et al [ 98 ] found normal working memory span in children with bilateral PVD. However, compared to healthy controls, average performance of children with bilateral PVD was reduced.…”

Section: Discussionmentioning

confidence: 99%

“…Some other studies, however, did not find reduced inhibition or working memory performance in patients with bilateral or chronic unilateral PVD [ 1 , 23 , 75 , 98 ]. Cognitive flexibility was reduced in patients with chronic unilateral [ 26 , 31 ], but normal in patients with bilateral [ 101 ] or a mixed sample of bilateral and chronic unilateral PVD [ 74 , 98 ].…”

Section: Introductionmentioning

confidence: 94%

“…However, patients with bilateral PVD performed equally as healthy controls in a verbal fluency task, a subdomain of initiation [ 101 ]. Inhibition and working memory were found to be reduced in patients with bilateral, chronic unilateral, and acute unilateral PVD [ 1 , 4 , 23 , 26 , 31 , 56 , 70 , 71 , 75 , 77 , 98 ]. Some other studies, however, did not find reduced inhibition or working memory performance in patients with bilateral or chronic unilateral PVD [ 1 , 23 , 75 , 98 ].…”

Section: Introductionmentioning

confidence: 99%

“…Inhibition and working memory were found to be reduced in patients with bilateral, chronic unilateral, and acute unilateral PVD [ 1 , 4 , 23 , 26 , 31 , 56 , 70 , 71 , 75 , 77 , 98 ]. Some other studies, however, did not find reduced inhibition or working memory performance in patients with bilateral or chronic unilateral PVD [ 1 , 23 , 75 , 98 ]. Cognitive flexibility was reduced in patients with chronic unilateral [ 26 , 31 ], but normal in patients with bilateral [ 101 ] or a mixed sample of bilateral and chronic unilateral PVD [ 74 , 98 ].…”

Section: Introductionmentioning

confidence: 99%

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Executive functions in patients with bilateral and unilateral peripheral vestibular dysfunction

Schöne,

Vibert,

Mast

2024

J Neurol

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Previous research suggests that patients with peripheral vestibular dysfunction (PVD) suffer from nonspatial cognitive problems, including executive impairments. However, previous studies that assessed executive functions are conflicting, limited to single executive components, and assessments are confounded by other cognitive functions. We compared performance in a comprehensive executive test battery in a large sample of 83 patients with several conditions of PVD (34 bilateral, 29 chronic unilateral, 20 acute unilateral) to healthy controls who were pairwise matched to patients regarding age, sex, and education. We assessed basic and complex executive functions with validated neuropsychological tests. Patients with bilateral PVD performed worse than controls in verbal initiation and working memory span, while other executive functions were preserved. Patients with chronic unilateral PVD had equal executive performance as controls. Patients with acute unilateral PVD performed worse than controls in the exact same tests as patients with bilateral PVD (verbal initiation, working memory span); however, this effect in patients with acute PVD diminished after correcting for multiple comparisons. Hearing loss and affective disorders did not influence our results. Vestibular related variables (disease duration, symptoms, dizziness handicap, deafferentation degree, and compensation) did not predict verbal initiation or working memory span in patients with bilateral PVD. The results suggest that bilateral PVD not only manifests in difficulties when solving spatial tasks but leads to more general neurocognitive deficits. This understanding is important for multidisciplinary workgroups (e.g., neurotologists, neurologists, audiologists) that are involved in diagnosing and treating patients with PVD. We recommend screening patients with PVD for executive impairments and if indicated providing them with cognitive training or psychoeducational support.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Executive functions in patients with bilateral and unilateral peripheral vestibular dysfunction

Schöne,

Vibert,

Mast

2024

J Neurol

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A Clinical Framework for Video Head Impulse Testing and Vestibular Evoked Myogenic Potential Assessments in Primary School-Aged Children

Van Hecke,

Deconinck,

Danneels

et al. 2024

Ear &Amp; Hearing

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Objectives: This study aimed to offer normative data and age trends of an age-appropriate vestibular test protocol in a large group (n = 140) of school-aged children (6 to 13 years old) as well as to provide a practical and clinical framework for accurate performance and interpretation of vestibular test results in this specific age group. Design: The typically developing participants (mean age of 9.51 ± 2.04 years) were recruited to provide a representative group of 20 children for each of the seven age groups that were composed of children aged from 6 to 13 years in 1-year intervals. Each age group consisted of 10 boys and 10 girls. The protocol comprises the video head impulse test, and cervical and ocular vestibular evoked myogenic potential assessments to provide a child-friendly, noninvasive, short, and portable test battery, which is equally applicable in the hospital and office-practice, and which provides information on the integrity of all five parts of the peripheral vestibular system. Results: The study demonstrates that all included tests and methods, with an overall test duration of 25 min 12 sec ± 5 min 10 sec, were feasible to perform in primary school-aged children, taking into account some practical adaptations. Concerning the video head impulse test, no clinically relevant sex and age effects were noted. However, t tests revealed significant differences for the mean gain of the horizontal (right > left; t[139] = 14.563; p < 0.001) and posterior semicircular canals (left > right; t[139] = −4.823; p < 0.001) between both sides. For the cVEMP assessment, no laterality differences were observed for any of the parameters, but a significantly shorter N1 latencies in the youngest age categories (<8 years), compared with the oldest groups were observed [F(6,118) = 8.336; p < 0.001; partial ƞ² = 0.298]. For all oVEMP parameters, no laterality, sex, or age differences were seen. On the basis of the presented normative data, cutoff criteria were proposed with accompanying clinical recommendations to perform vestibular function testing in this target population. Conclusions: This is the first study in a large group of school-aged children offering normative data and age trends of an age-appropriate vestibular test protocol that evaluates the integrity of all parts of the peripheral vestibular organ. The reported normative values and clinical cutoff values will enable appropriate and age-specific interpretation of clinical and scientific results. Moreover, in combination with extensive history taking, and additional vestibular testing (e.g., rotatory chair test, caloric testing) when needed, the results of this study may support clinicians in the diagnosis of side-specific and location-specific vestibular deficits, which is required for accurate counseling and referral for further follow-up and/or intervention.

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A cross-sectional study on the neurocognitive outcomes in vestibular impaired school-aged children: are they at higher risk for cognitive deficits?

Cited by 2 publications

References 52 publications

Executive functions in patients with bilateral and unilateral peripheral vestibular dysfunction

Executive functions in patients with bilateral and unilateral peripheral vestibular dysfunction

A Clinical Framework for Video Head Impulse Testing and Vestibular Evoked Myogenic Potential Assessments in Primary School-Aged Children

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