A cross‐sectional study on clinico‐dermoscopic features of periorbital melanosis in a tertiary care hospital

Abstract

Introduction Periorbital melanosis (POM) is an esthetic facial concern on increasing trend and has a severe emotional impact on patients. We aimed to study the clinical and dermoscopic patterns of periorbital melanosis to aid in the classification and strategize therapy. Methods A cross‐sectional, observational study was conducted on one hundred patients with POM in a tertiary care center in India from January 2020‐March 2020. Dermoscopic assessment of POM was done using video dermatoscope– FotoFinder Medicam 1000s (magnification up to 140x). Results The mean age of participants was 32.8 ± 9 years. It was more prevalent among females (78%). The constitutional type (43%) of POM was the most common followed by shadow‐effect type (32%). The various dermoscopic pigmentary patterns seen were scattered pigmented dots (56%), exaggerated pigment network (31%), globules (30%), and blotches (27%). Dilated veins and telangiectasia were seen in 50% and 32% of subjects, respectively. Exaggerated skin markings were seen in 43% of participants. Scattered pigmented dots were most commonly seen in constitutional, vascular, and shadow types but were significantly associated with vascular type. Exaggerated pigment network was the most frequent pigmentary pattern in post‐inflammatory type of POM. Globules were significantly associated with constitutional as well as shadow type of POM and blotches with shadow type of POM. Conclusions Periorbital melanosis presents as multifactorial entity with constitutional type being the most common. The dermoscopic patterns of POM may provide a clue to the underlying etiology, thereby helping to plan appropriate treatment.

Novel Hydrogenated Derivatives of Chemically Modified Curcumin CMC2.24 Are Potent Inhibitors of Melanogenesis in an In Vitro Model: Influence of Degree of Hydrogenation

“…Bisdemethoxycurcumin has been shown to have low or negligible antioxidant activity [27], and we have shown that CMC2.24 lacked antioxidant activity as evaluated by DPPH radical assay in our previous report [11]. Thus, owing to the lack of antioxidant activity of the parent compound 1 (CMC2.24), the different products (2)(3)(4)(5) formed by hydrogenation reactions also lacked antioxidant activity. Based on the results of the DPPH radical scavenging assay and cellular ROS production in HEMn-DP cells, we concluded that these products do not display any antioxidant capacity.…”

“…The overproduction and oversecretion of melanin pigment by specialized cells melanocytes is the causative factor in the occurrence of hyperpigmentation disorders of the skin, which Life 2023, 13, 1373 2 of 23 comprise melasma [1], solar lentigines, freckles, diffuse hyperpigmentation [2], periorbital melanosis [3], post-inflammatory hyperpigmentation [4], and drug-induced hyperpigmentation [5]. The current market for treating global pigmentation disorders is projected to reach USD 11.2 billion by 2030 with a cumulative annual growth rate (CAGR) of 6.8% [6].…”