A cross-sectional study of the relationship between body mass index and clinical characteristics, tenderness measures, quality of life, and physical functioning in fibromyalgia patients

Neumann, Lily; Lerner, Ella; Glazer, Yael; Bolotin, Arkady; Shefer, Alexander; Buskila, Dan

doi:10.1007/s10067-008-0966-1

Cited by 138 publications

(128 citation statements)

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“…Many patients with fibromyalgia are overweight and sedentary, and recent studies suggest that obesity in patients with fibromyalgia is associated with increased dysfunction (31,32). Similar to the previous fibromyalgia trials, the mean baseline body mass index for the participants in this trial was ϳ31 kg/m 2 , which exceeds the World Health Organization threshold for obesity (33).…”

Section: Discussionsupporting

confidence: 67%

Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: Results of a randomized, double‐blind, placebo‐controlled trial

Arnold

Gendreau

Palmer³

et al. 2010

Arthritis & Rheumatism

128

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Objective. To assess the efficacy and safety of milnacipran at a dosage of 100 mg/day (50 mg twice daily) for monotherapy treatment of fibromyalgia.Methods. A double-blind, placebo-controlled trial was performed to assess 1,025 patients with fibromyalgia who were randomized to receive milnacipran 100 mg/day (n ‫؍‬ 516) or placebo (n ‫؍‬ 509). Patients underwent 4-6 weeks of flexible dose escalation followed by 12 weeks of stable-dose treatment. Two composite responder definitions were used as primary end points to classify the response to treatment. The 2-measure composite response required achievement of >30% improvement from baseline in the pain score and a rating of "very much improved" or "much improved" on the Patient's Global Impression of Change (PGIC) scale. The 3-measure composite response required satisfaction of these same 2 improvement criteria for pain and global status as well as improvement in physical function on the Short Form 36 (SF-36) physical component summary (PCS) score.Results. After 12 weeks of stable-dose treatment, a significantly greater proportion of milnacipran-treated patients compared with placebo-treated patients showed clinically meaningful improvements, as evidenced by the proportion of patients meeting the 2-measure composite responder criteria (P < 0.001 in the baseline observation carried forward [BOCF] analysis) and 3-measure composite responder criteria (P < 0.001 in the BOCF). Milnacipran-treated patients also demonstrated significantly greater improvements from baseline on multiple secondary outcomes, including 24-hour and weekly recall pain score, PGIC score, SF-36 PCS and mental component summary scores, average pain severity score on the Brief Pain Inventory, Fibromyalgia Impact Questionnaire total score (all P < 0.001 versus placebo), and Multidimensional Fatigue Inventory total score (P ‫؍‬ 0.036 versus placebo). Milnacipran was well tolerated by most patients, with nausea being the most commonly reported adverse event (placebo-adjusted rate of 15.8%).Conclusion. Milnacipran administered at a dosage of 100 mg/day improved pain, global status, fatigue, and physical and mental function in patients with fibromyalgia.

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Section: Discussionsupporting

confidence: 67%

Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: Results of a randomized, double‐blind, placebo‐controlled trial

Arnold

Gendreau

Palmer³

et al. 2010

Arthritis & Rheumatism

128

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“…Mesmo assim, a baixa distância percorrida pode ser um indicativo de um comprometimento da capacidade funcional e isso pôde ser demonstrado neste estudo pela correlação moderada e negativa encontrada entre o HAQ e a Uma característica bem marcante também nestes pacientes é que a maioria dos indivíduos apresenta sobrepeso ou obesidade. No atual estudo, também encontrou-se um alto percentual (81,50%) para excesso de peso, prevalência esta maior que os 73% encontrados recentemente 27 . Yunus et al 8 afirmam que esta síndrome está relacionada diretamente com um baixo rendimento físico nesses pacientes, enquanto Guler e Sahin 9 relatam que este baixo rendimento físico está simplesmente associado com o IMC elevado nestes mesmos indivíduos.…”

Section: Discussionunclassified

Avaliação da capacidade funcional de mulheres com fibromialgia: métodos diretos e autorrelatados. DOI: 10.5007/1980-0037.2011v13n4p292

Homann

Góes

Timossi

et al. 2011

Rev. Bras. Cineantropom. Desempenho Hum.

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Avaliação da capacidade funcional de mulheres com fibromialgia: métodos diretos e autorrelatados Assessment of functional capacity in women with fibromyalgia: direct and self-reported methodsResumo -A Fibromialgia (FM) pode limitar a execução das atividades da vida diária (AVD's) e causar impacto negativo na qualidade de vida (QV) destes pacientes. O objetivo deste estudo foi verificar associações entre métodos diretos e indiretos para avaliar a capacidade funcional e a relação destes com algumas características da FM. Participaram do estudo 38 mulheres com diagnóstico de FM. A capacidade funcional foi avaliada através do Health Assessment Questionnaire (HAQ), distância no teste de caminhada de 6 minutos (DTC6) e força de preensão manual (FPM). Aplicou-se o Fibromyalgia Impact Questionnaire (FIQ) para avaliar o impacto na qualidade de vida, a escala visual analógica para mensurar a dor, além da avaliação do índice de massa corporal e circunferência abdominal. Utilizou--se correlação de Pearson para dados paramétricos e de Spearman para não-paramétricos. Além disso, algumas regressões múltiplas foram realizadas. As pacientes apresentaram alta intensidade dolorosa (mediana de 9,5). As correlações encontradas foram: DTC6 versus HAQ (r=-0,55 p<0,01), DTC6 versus FPM (r=0,34 p<0,01), dor versus FPM (r=-0,41 p<0,01), dor versus HAQ (r=0,62 p<0,01) e dor versus FIQ (r=0,66 p<0,01). A intensidade dolorosa explicou uma variação de 40% na pontuação do HAQ e após a inclusão da DTC6, essa variação aumentou para 60%. Em conclusão, a dor parece comprometer a FPM, as AVD's e a QV destas pacientes. O menor desempenho na DTC6 foi explicado pelo aumento do índice de massa corporal. Em relação à interferência da dor, o HAQ parece ser um instrumento adequado para mensurar a capacidade funcional de mulheres com fibromialgia. Palavras-chave: Dor; Exercíco físico; Obesidade; Qualidade de vida. p<0.01) and HGS (r=0.34, p<0.01). Pain was correlated with p<0.01), HAQ score (r=0.62, p<0.01), and FIQ (r =0.66, p<0.01 Abstract -Fibromyalgia can limit activities of daily living (ADLs) performance and has a negative impact on the quality of life of these patients. The objective of this study was to evaluate the association between direct and indirect methods for the assessment of functional capacity and their relationship with some features of fibromyalgia. Thirty-eight women with a diagnosis of fibromyalgia participated in the study. Functional capacity was assessed by the Health Assessment Questionnaire (HAQ), distance in the six-minute walk test (6MWT), and handgrip strength (HGS). Pain was rated on a visual analog scale. The Fibromyalgia Impact

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“…In fact, overweight and obesity are highly frequent in these people, and body mass index has a negative correlation with quality of life and tenderness threshold, and a positive correlation with physical dysfunction and pain point count. Obese FM patients show higher pain sensitivity and lower levels of quality of life [52]. The high prevalence of overweight and obesity was showed also in a health telephonic survey made only on female participants, with and without FM.…”

Section: Fibromyalgia and Nutritional Statusmentioning

confidence: 78%

Fibromyalgia and nutrition, what do we know?

Arranz

Canela²,

Rafecas

2010

Rheumatol Int

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Objective: Many people suffer from fibromyalgia (FM) without an effective treatment. They do not have a good quality of life and cannot maintain normal daily activity. Among the different hypotheses for its ethiopathophysiology, oxidative stress is one of the possibilities. Non-scientific information addressed to patients regarding the benefits of nutrition is widely available, and they are used to trying non-evidenced strategies. The aim of this paper is to find out what we know right now from scientific studies regarding fibromyalgia disease and nutritional status, diets and food supplements. Design: A systematic search has been performed on Medline with a wide range of terms about these nutritional issues. Setting: the search has been made during 2009, for articles published between 1998 and 2008. Subjects: people suffering from FM. Results: Vegetarian diets could have some beneficial effects probably due to the increase in antioxidant intake. There is a high prevalence of obesity and overweight in patients, and weight control seems to be an effective tool to improve the symptoms. Some nutritional deficiencies have been described, it is not clear whether they are directly related to this disease or not. About the usefulness of some food supplements we found very little data, and it seems that more studies are needed to prove which ones could be of help. Conclusions: Dietary advice is necessary to these patients to improve their diets and maintain normal weight. It would be interesting to investigate more in the field of nutrition and FM to reveal any possible relationships.

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A cross-sectional study of the relationship between body mass index and clinical characteristics, tenderness measures, quality of life, and physical functioning in fibromyalgia patients

Cited by 138 publications

References 20 publications

Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: Results of a randomized, double‐blind, placebo‐controlled trial

Efficacy and safety of milnacipran 100 mg/day in patients with fibromyalgia: Results of a randomized, double‐blind, placebo‐controlled trial

Avaliação da capacidade funcional de mulheres com fibromialgia: métodos diretos e autorrelatados. DOI: 10.5007/1980-0037.2011v13n4p292

Fibromyalgia and nutrition, what do we know?

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