A Cross-Sectional Study of Serum Ferritin Levels in Vietnamese Adults with Metabolic Syndrome

Abstract

Background Metabolic syndrome is one of the most common public health concerns in the 21st century. Several previous studies have shown an association between increased serum ferritin levels and other components of metabolic syndrome and the risk of metabolic syndrome. They conclude that ferritin can be viewed as a predictor of metabolic syndrome risk. This study investigates some main features of metabolic syndrome and the serum ferritin levels in a Vietnamese adult cohort with metabolic syndrome. Methods A descriptive cross-sectional study was conducted on 207 patients who were treated at the General Internal Medicine-Geriatric Department, Hue Central Hospital, from May 2018 to August 2020. Patients were divided into two groups: the study group (104 patients with metabolic syndrome) and the control group (103 patients without metabolic syndrome and no serum ferritin-mediated disease). The metabolic syndrome was diagnosed by a joint interim statement of the International Diabetes Federation/American Heart Association/National Heart, Lung, and Blood Institute/World Heart Federation/International Atherosclerosis Society/International Association for the Study of Obesity in 2009. Results Hypertriglyceridemia–hypertension–hyperglycemia (50.9%) is the most common combination of metabolic syndrome components. The mean serum ferritin concentration was 391.62±181.97ng/mL and 124.55±63.95ng/mL in the metabolic syndrome and control groups, respectively. In the metabolic syndrome group, increased ferritin concentration accounted for 86.54% for men, the mean serum ferritin concentration was 453.064 ± 161.75ng/mL (increased ferritin concentration accounted for 96.15%) for women; the mean serum ferritin concentration was 330.17 ± 181.71 ng/mL (increased ferritin concentration accounted for 86.54%). Conclusion The serum ferritin level is significantly increased in Vietnamese patients with metabolic syndrome.

Are monoclonal antibodies effective in patients with severe obesity in SARS‐CoV‐2 infected?

“…18 Furthermore, in obese patients, considering the chronic inflammatory state, there are already high levels of ferritin regardless of the infection. 19 So we demonstrated that MonoAbs remain a viable therapeutic option to treat COVID-19 disease and its complications, especially in obese individuals. Although they were not vaccinated and had a very high risk of serious illness, the infection after therapy resolved without complications.…”

“… 18 Furthermore, in obese patients, considering the chronic inflammatory state, there are already high levels of ferritin regardless of the infection. 19 …”

“…Many studies linked high ferritin levels with fatal outcomes of COVID‐19 18 . Furthermore, in obese patients, considering the chronic inflammatory state, there are already high levels of ferritin regardless of the infection 19 …”

Association Between Serum Ferritin Concentration and Risk of Adverse Maternal and Fetal Pregnancy Outcomes: A Retrospective Cohort Study

“…Among them, serum ferritin (SF) is the most used clinically. Previous animal and epidemiological studies observed a significant association between excess SF storage and glucose metabolism disorders, [10][11][12] and others have found a positive association between ferritin and type 2 diabetes. 13,14 Then, some epidemiological studies have investigated the relationship between high SF concentrations and the incidence of gestational diabetes mellitus (GDM), but the results have been controversial.…”

Relation between erythropoietin resistance and metabolic syndrome in hemodialysis patients: A multicentric propensity score matched analysis

“…24 Similar findings were noted by other studies. 25,26 In patients with cardiovascular risk, hyperferritinemia was found to be well-correlated with MetS. 27 Likewise, the study of Srivastav et al 28 found as association between increased ferritin levels and MetS in hospitalized patients.…”