A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China

Tang, Yunju; Shi, Linjun; Borén, Jan; Zhou, Zengtong; Shen, Xuemin

doi:10.3389/fendo.2019.00928

Cited by 10 publications

(18 citation statements)

References 31 publications

(28 reference statements)

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“…Numerous data come from the Chinese population, where a greater prevalence of TD, in particular HT, was found in patients with OLP [18][19][20] and the correlation between these conditions seemed to reside in common autoimmune pathways. 19 Current worldwide literature has shown that, among TD, hypothyroidism is the most frequently found condition in patients with a diagnosis of OLP.…”

Section: Discussionmentioning

confidence: 99%

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The Correlation between Oral Lichen Planus and Thyroid Pathologies: A Retrospective Study in a Sample of Italian Population

Piloni,

Ferragina,

Barca

et al. 2023

Eur J Dent

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Objectives The association between oral lichen planus and thyroid disorders, especially hypothyroidism and Hashimoto's thyroiditis, has been discussed in current literature with conflicting outcomes. Materials and Methods The study retrospectively evaluated the thyroid status in patients diagnosed with oral lichen planus and oral lichenoid lesions. A case–control approach was used to prove that thyroid disorders were statistically significant risk factors for oral lichen planus and oral lichenoid lesions. Statistical Analysis To evaluate these associations, odds ratios (ORs) were used. ORs precision and statistical significance were estimated using a 95% confidence interval (CI) and p-value, respectively. Results A total of 307 patients were involved in the study: 158 females and 149 males. OR, 95% CIs, and p-values were analyzed. Patients with thyroid diseases showed an increased risk of developing oral lichen planus (OR: 4.29, 95% CI: 1.85–9.96, p-value: 0.0007) and oral lichenoid lesions (OR: 2.76, 95% CI: 1.24–6.13, p-value: 0.0129). This association was maintained in patients with oral lichen planus, while also considering hypothyroidism (OR: 3.74, 95% CI: 1.46–9.58, p-value: 0.0059) and Hashimoto's thyroiditis (OR: 4.57, 95% CI: 1.58–13.23, p-value: 0.005) alone. The correlation of hypertension, diabetes, dyslipidemia, and smoking status with oral lichen planus and oral lichenoid lesions was also evaluated but no statistical significance was found. Conclusion Even if further investigations are needed, the association between oral lichen planus and oral lichenoid lesions with thyroid pathologies should be taken into consideration by endocrinologists due to the potential malignancy of these disorders.

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Section: Discussionmentioning

confidence: 99%

“…Numerous data come from the Chinese population, where a greater prevalence of TD, in particular HT, was found in patients with OLP 18 19 20 and the correlation between these conditions seemed to reside in common autoimmune pathways. 19 …”

Section: Discussionmentioning

confidence: 99%

The Correlation between Oral Lichen Planus and Thyroid Pathologies: A Retrospective Study in a Sample of Italian Population

Piloni,

Ferragina,

Barca

et al. 2023

Eur J Dent

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“…Muzio ( 20 ) reported the HT prevalence rate in patients with OLP was 14.29% (15/105) in Italy. Tang ( 26 ) reported that the prevalence was 12.14% (71/585) in East China. Zhou ( 24 ) reported that the prevalence was 20.83% (40/192).…”

Section: Discussionmentioning

confidence: 99%

Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study

et al. 2022

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Hashimoto’s thyroiditis (HT) and its autoantibodies may be associated with oral lichen planus (OLP). In this cross-sectional study, we aimed to assess the relationship among HT, auto-anti-thyroid antibodies, and OLP in a Chinese population of 247 patients with oral lichen planus. Clinical manifestations of OLP were evaluated using the Thongprasom scoring system and clinical type. The diagnosis of HT was based on thyroid function, anti-thyroid peroxidase antibody (anti-TPOAb) and anti-thyroglobulin antibody (anti-TgAb) detection, and ultrasonography. The prevalence of HT in all patients with OLP was 39.68% (98/247); the prevalence in females with OLP was 46.24% (86/186), which was higher than that in males with OLP 19.67% (12/61) (P < 0.01). The titers of the two HT autoantibodies in females with OLP were higher than those in males (P < 0.01). The clinical manifestations of OLP, regardless of being evaluated using the Thongprasom system or clinical type, were not significantly associated with HT development or TPOAb (P = 0.864) or TgAb titers (P = 0.745). In this population-based southern Chinese cohort, the prevalence of HT in patients with OLP, particularly in female patients with OLP, was significantly higher than that in the general population. Female patients had higher HT autoantibody titers than male patients. However, the clinical manifestations of OLP were not significantly correlated with either HT development or auto-anti-thyroid antibody levels. The findings could help further elucidate the factors involved in the relationship between oral lichen planus and Hashimoto’s thyroiditis.

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“…An increasing number of studies have investigated the possible relationship between thyroid diseases (Hashimoto thyroiditis, hyperthyroidism, thyroid cancer, etc.) and OLP/OLL [13][14][15]. However, OLL coexisting with CD and papillary thyroid carcinoma (PTC) is very rarely described.…”

Section: Introductionmentioning

confidence: 99%

Oral lichenoid lesion simultaneously associated with Castleman’s disease and papillary thyroid carcinoma: a rare case report

Zhou

Tan

et al. 2022

BMC Oral Health

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Background Oral lichenoid lesion (OLL) is a term used to describe oral lesions that have clinical and/or histopathological features similar to oral lichen planus (OLP), but it is thought to be caused by specific triggers or systemic conditions and presents higher malignant transformation rate than OLP. To date, OLL simultaneously complicated with Castleman’s disease (CD) and papillary thyroid carcinoma (PTC) has not been reported. Reporting from such disorders is crucial to avoid misdiagnosis and help in timely intervention. Case presentation We report a rare case of a 39-year-old female with extensive ulcerated lesions on the oral mucosa, diagnosed as OLL by histopathology. Routine oral treatment was scheduled to control the OLL, while the oral lesions remained unhealed. Computed tomography examination was performed after the oral treatment and revealed thyroid and mediastinal masses, which were then surgically removed and pathologically diagnosed as PTC and CD, respectively. Two months after complete excision of the neoplasms, the oral lesions showed obvious alleviation. With subsequent treatment for oral lesions, the patient’s OLL healed. Conclusions This is the first reported OLL case simultaneously associated with CD and PTC. This case reminds us to focus on the underlying etiologies of OLL and the multidisciplinary collaboration for oral lesions associated with systemic diseases.

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A Cross-Sectional Study of Oral Lichen Planus Associated With Thyroid Diseases in East China

Cited by 10 publications

References 31 publications

The Correlation between Oral Lichen Planus and Thyroid Pathologies: A Retrospective Study in a Sample of Italian Population

The Correlation between Oral Lichen Planus and Thyroid Pathologies: A Retrospective Study in a Sample of Italian Population

Association of Hashimoto’s thyroiditis and anti-thyroid antibodies with oral lichen planus: A cross-sectional study

Oral lichenoid lesion simultaneously associated with Castleman’s disease and papillary thyroid carcinoma: a rare case report

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