A Cross-Sectional Study of Dietary and Genetic Predictors of Blood Folate Levels in Healthy Young Adults

Cummings, Daniel K.; Dowling, Kevin; Silverstein, Noah J.; Tanner, Alexandra; Eryilmaz, Hamdi; Smoller, Jordan W.; Roffman, Joshua L.

doi:10.3390/nu9090994

Cited by 9 publications

(5 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, 5% of the variation in RBC deficiency can be explained by intake of folic acid-containing supplements, the highest variability among all selected variables used in this study. The result of regression analysis was consistent with the results of studies conducted in different regions in the recent years (Cummings et al, 2017;Ma et al, 2017).…”

Section: Discussionsupporting

confidence: 88%

Prevalence and factors associated with folate deficiency among Filipino women of child-bearing age

Bernardo¹,

Gordoncillo²,

Atienza³

et al. 2020

Mal J Nutr

View full text Add to dashboard Cite

Introduction: Folate deficiency is associated with many complications of pregnancy. A cross-sectional survey was conducted to determine the prevalence and factors associated with deficiency in red blood cell (RBC) folate among Filipino women of child-bearing age in the Province of Batangas, Philippines. Methods: A total of 184 Filipino women aged 15 to 49 years were interviewed on their socio-economic and demographic profiles. Mean energy and folate intakes were obtained using food recalls over a three-month period. RBC folate was used to measure long-term folate status and analysed through immuno-assay method. Results: About two in ten women were folate deficient based on the normal cut-off points (<400 ng/mL) preventive of neural tube defect-affected pregnancies. Respondents have very low intake of folate at 81 and 239 micrograms dietary folate equivalent (µg DFE) from dietary sources and with folic acid supplementation, respectively. Vegetable gardening and livestock raising (p<0.10) and use of folic-acid containing supplements showed significant correlations with folate status (p<0.05). Further, regression analysis showed that among the significant factors, the non-usage of folic acid-containing supplements showed increased likelihood of RBC folate deficiency by six times compared to users (OR=6.391, p<0.10). Conclusion: The findings of the study suggest a high prevalence of folate deficiency among Filipino women. Folate is an essential nutrient for healthy pregnancy. It is important that women, capable of bearing a child must assure adequate folate intake from foods and folic-acid containing supplements. The study recommends a more aggressive campaign on the importance of folate among women of child-bearing age.

show abstract

Section: Discussionsupporting

confidence: 88%

Prevalence and factors associated with folate deficiency among Filipino women of child-bearing age

Bernardo¹,

Gordoncillo²,

Atienza³

et al. 2020

Mal J Nutr

View full text Add to dashboard Cite

show abstract

“…Additionally, folate hydrolase 1 (FOLH1) an enzyme located on the intestinal brush border membrane is responsible for the cleavage of the polyglutamated tail from naturally occurring food folate before it can be absorbed. Cummings and colleagues showed, that carriers of the FOLH1 484 C variant could absorb naturally occurring food folate less well than T carriers …”

Section: Vitaminsmentioning

confidence: 99%

GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract

Walther

Lett

Bordoni

et al. 2019

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Nutritional research is currently entering the field of personalized nutrition, to a large extent driven by major technological breakthroughs in analytical sciences and biocomputing. An efficient launching of the personalized approach depends on the ability of researchers to comprehensively monitor and characterize interindividual variability in the activity of the human gastrointestinal tract. This information is currently not available in such a form. This review therefore aims at identifying and discussing published data, providing evidence on interindividual variability in the processing of the major nutrients, i.e., protein, fat, carbohydrates, vitamins, and minerals, along the gastrointestinal tract, including oral processing, intestinal digestion, and absorption. Although interindividual variability is not a primary endpoint of most studies identified, a significant number of publications provides a wealth of information on this topic for each category of nutrients. This knowledge remains fragmented, however, and understanding the clinical relevance of most of the interindividual responses to food ingestion described in this review remains unclear. In that regard, this review has identified a gap and sets the base for future research addressing the issue of the interindividual variability in the response of the human organism to the ingestion of foods.

show abstract

“…Higher red blood cell folate levels were observed with increased folate intake in the US population carrying the TT genotype of Folate Hydrolase 1 ( FOLH1 ) T484C, compared to C allele carriers (Cummings et al. 2017 ). However, Japanese women carrying the TT genotype of Methylene tetrahydrofolate reductase ( MTHFR ) 677 C > T had significantly lower serum folate with increased intake of folic acid compared to non-carriers (Hiraoka 2004 ).…”

Section: Resultsmentioning

confidence: 99%

“… 2005 ) and FOLH1 T484C (Cummings et al. 2017 ) were associated significantly higher ferritin levels with higher intakes of heme iron and folate, respectively.…”

Section: Discussionmentioning

confidence: 97%

In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status

Tan

Moore

Bai

et al. 2022

Critical Reviews in Food Science and Nutrition

View full text Add to dashboard Cite

Genetic background interacts with dietary components to modulate nutritional health status. This study aimed to review the evidence for gene-diet interactions in all forms of malnutrition. A comprehensive systematic literature search was conducted through April 2021 to identify observational and intervention studies reporting the effects of gene-diet interactions in over-nutrition, under-nutrition and micronutrient status. Risk of publication bias was assessed using the Quality Criteria Checklist and a tool specifically designed for gene-diet interaction research. 167 studies from 27 populations were included. The majority of studies investigated single nucleotide polymorphisms (SNPs) in overnutrition (n = 158). Diets rich in whole grains, vegetables, fruits and low in total and saturated fats, such as Mediterranean and DASH diets, showed promising effects for reducing obesity risk among individuals who had higher genetic risk scores for obesity, particularly the risk alleles carriers of FTO rs9939609, rs1121980 and rs1421085. Other SNPs in MC4R , PPARG and APOA5 genes were also commonly studied for interaction with diet on overnutrition though findings were inconclusive. Only limited data were found related to undernutrition (n = 1) and micronutrient status (n = 9). The findings on gene-diet interactions in this review highlight the importance of personalized nutrition, and more research on undernutrition and micronutrient status is warranted.

show abstract

A Cross-Sectional Study of Dietary and Genetic Predictors of Blood Folate Levels in Healthy Young Adults

Cited by 9 publications

References 77 publications

Prevalence and factors associated with folate deficiency among Filipino women of child-bearing age

Prevalence and factors associated with folate deficiency among Filipino women of child-bearing age

GutSelf: Interindividual Variability in the Processing of Dietary Compounds by the Human Gastrointestinal Tract

In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status

Contact Info

Product

Resources

About