A cross-sectional study of cutaneous drug reactions in a private dental college and government medical college in eastern India

Chattopadhyay, Chandan; Chakrabarti, N.B.

doi:10.4103/1119-3077.97317

Cited by 8 publications

(19 citation statements)

References 3 publications

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“…Altogether we observed 18 different types of cutaneous adverse drug reactions. Exanthematous type was the commonest type of reaction observed in our study which is in accordance to the finding of several other authors 4,8,12,[15][16][17] . Fixed drug eruption was the second most common drug eruption seen in our study similar to the finding of Patel RM et al 18 .…”

Section: Discussionsupporting

confidence: 93%

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Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Neupane

Basnet

2018

J. Gandaki Med. Coll. Nepal

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Background: Cutaneous adverse drug reactions (CADRs) range from minor reactions to several life threatening complications. Objectives: To study the clinical spectrum of cutaneous adverse drug reactions, determine the causative drugs responsible for the reactions and to assess the preventability.Methods: The study was carried out in the Department of Dermatology of Gandaki Medical College Teaching Hospital from June 2011 to June 2015. All the patients attending the Dermatology Outpatient Department and the patients admitted in the wards with suspected cutaneous adverse drug reactions to systemic drugs were included in the study. A detailed clinical history, including the history of drug intake was noted. Each case was assessed for its causality by using the WHO definitions. Data analysis was done using SPSS software.Results: There were 102 patients in total. The mean age of the patient was 32 ±15.7 years. Maximum patients belonged to the 21 to 30 years age group. There were 59 female patients and 43 male patients. Severe type of cutaneous adverse drug reactions was noted in 7.8% of patients. Antibiotics were responsible for most of the cutaneous adverse drug reactions. Cefixime was the most commonly incriminated drug. Exanthematous drug reaction was the most common type seen in 45%. Stevens-Johnson syndrome was the commonest type noted among the serious adverse drug reactions. Drug preventability was noted in 6% of patients.Conclusions: The commonest type of CADR noted was exanthematous type. Antibiotics were the commonest drug group involved in CADR. Six percent of CADR were preventable. J-GMC-N | Volume 11 | Issue 01 | January-June 2018, Page: 21-26

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Section: Discussionsupporting

confidence: 93%

“…Antimicrobials was the commonest drug category of drug involved in CADR observed by several authors 8,12,16 . Antibiotic was the most common cause of CADR in our study.…”

Section: Discussionmentioning

confidence: 97%

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Neupane

Basnet

2018

J. Gandaki Med. Coll. Nepal

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“…Of the various cutaneous ADRs, Fixed Drug Eruption including the bullous variant was the commonest, seen in 64 (45.71%) patients, similar to the findings of study by Chatterjee et al, 2 Patel et al, 3 Qayoom et al, 4 but in contrast to Chattopadhyay et al, 5 Jha et al, 6 Saha et al, 7 Hiware et al 8 and Jhaj et al 9 Maculopapular Rash followed this in 24(17.14%), followed by SJS in 16 (11.42%). Fifteen cases of FDE and three cases of its bullous variant were caused by Fixed dose combination of ofloxacin and ornidazole.bMale preponderance was seen with a M: F ratio of 2.25: 1.This was similar to the findings by Sharma et al 10 and Patel et al 3 However studies by Chattopadhyay et al, 5 Nandha et al, 11 Sehgal et al 12 and Pudukadan et al 13 showed an equal or a female preponderance. Higher male proportion in our study could be because of medical seeking behavior of males.…”

Section: Discussionsupporting

confidence: 85%

Clinico-Epidemiological Study of Cutaneous Adverse Drug Reactions: A Hospital-Based Study

Sharma¹,

Padhi²

2019

jebmh

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BACKGROUND Cutaneous drug reactions are the most common adverse reactions attributed to drugs. They often mimic or cause common cutaneous reaction patterns such as bullous disorders, lichen planus, psoriasis, eczema etc., METHODS It was a hospital based cross sectional study including 140 clinically diagnosed cases of Cutaneous Adverse Drug Reaction (CADR). Demographic details, clinical patterns, types of drugs and causality assessment were studied in each one of them. RESULTS Most common age group to have CADR was 21-40 years. The male to female ratio was 2.25:1. Fixed Drug Eruption including the bullous variant was the commonest, seen in 45.71% patients and followed by maculopapular rash in 17.14% and Stevens Johnson Syndrome (SJS) in 11.42%. The commonest offending group of drug as a whole was Antimicrobials (54.3%) followed by Non-Steroidal Anti Inflammatory Drugs (NSAID) (37.85%) and Antiepileptics (5.71%). CONCLUSIONS CADR commonly presents as Fixed Drug Eruption or maculopapular lesions and commonly implicated drugs are Antimicrobials, NSAIDs and Anti-Epileptics.

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“…11,12,15 This may be due to different prescription pattern by physicians or selfmedication in various setting for pain and fever. 11,12,[15][16][17]19,20 Anti-retroviral drugs and anti-convulsants are the common drugs causing severe drug reactions (11,6.5%) as SJS, TEN and DHS, amongst which SJS (6, 3%) was the commonest and these results were comparable to studies by Chatterjee et al and Chattopadhyay et al 3,7 The definite diagnosis was done in 28 cases (14%), possible in 56 cases (28%) and probable in 116 cases (58%) almost similar to study done by Puavilai et al and was in contrast to Thong et al study but the drawback of this assessment is the possibility of personal bias can be present because of disagreement in the causality assessment. 21,22 Limitations of our study were the definite association of drug reaction was not done in all patients as consent was not given in few cases and it was not done in severe drug reactions.…”

Section: Discussionsupporting

confidence: 60%

“…6 The current classification of adverse drug reactions (Table 4) which is most accepted is: a) Nonimmunological, b) Immunological (unpredictable) and c) miscellaneous. 6 Immunologic reactions require host immunological pathway, activation of host whereas nonimmunologic mechanisms occur due to side effects, overdosage, exacerbation of pre-existing conditions, etc 7 . Almost 75-80% of adverse drug reactions are caused by predictable, non-immunologic effects, remaining 20-25% are caused by unpredictable effect suggesting that majority was predictable.…”

Section: Discussionmentioning

confidence: 99%

The current trend of cutaneous drug reactions at a tertiary care hospital

Nagaraju

Puneetha

2019

Int J Res Dermatol

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Background: Cutaneous adverse drug reactions (CADR) are common yet important entity in dermatological clinical practice. This study is to investigate the clinical spectrum of CADR reactions and assess its causality relationship to offending drug.Methods: It was a cross-sectional observational study, conducted at a tertiary care hospital over a period of two years. Total of 200 patients with cutaneous drug rash diagnosed based on detailed history, correlation between drug intake and the onset of rash, thorough clinical examination and laboratory parameters were included and patients without details of drugs were excluded.Results: Among 200 cases, mean age was 33.57 years (6 months to 87 years). The commonest age group was 19-30 years (27%) and Male: female ratio was 0.94:1. The most common morphological pattern was maculopapular rash seen in 46 cases (23%), followed by FDE- 34 (17%), urticaria- 22 (11%), acneiform eruptions- 20 (10%), drug induced hyperpigmentation- 13 (6.5%), EMF- 12 (6%), lichenoid eruptions- 12 (6%), photosensitivity- 11 (5.5%), eczematous dermatitis- 6 (3%), pruritus- 6 (3%), angioedema- 6 (3%) and SJS- 6 (3%), DRESS- 2 (1%), TEN- 2 (1%), DHS and psoriasiform dermatitis in 1 each (0.5%) respectively. The most common drug was analgesics (31.2%), followed by anti-microbials (26.25%), corticosteroids (8.75%), antiepileptics (7.5%), anti-leprosy drugs (7.5%), anti-retroviral drugs (6.87%), antitubercular drugs (3.75%) and other drugs (8.12%).Conclusions: Many dermatological conditions can be induced, imitated or aggravated by drugs hence it is necessary for the health care system to promote periodic reporting to regional pharmacovigilance centres to ensure drug safety for clinician’s awareness.

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A cross-sectional study of cutaneous drug reactions in a private dental college and government medical college in eastern India

Abstract: Commonest drugs causing drug reactions are antibiotics mainly beta lactams and quinolones. Severe reactions were seen in our series with anticonvulsants and NSAIDS. Association with other diseases could not be inferred due to this modest patient pool.

Cited by 8 publications

References 3 publications

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Cutaneous Adverse Drug reactions: A Four-Year Study from Western Nepal

Clinico-Epidemiological Study of Cutaneous Adverse Drug Reactions: A Hospital-Based Study

The current trend of cutaneous drug reactions at a tertiary care hospital

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