A cross-sectional study of 130 Brazilian patients with Crohn’s disease and ulcerative colitis: analysis of articular and ophthalmologic manifestations

Abstract

This is a cross-sectional study that analyzed the pattern and frequency of articular and ophthalmologic manifestations in patients with Crohn's disease (CD) and ulcerative colitis (UC), with or without signs of active bowel inflammation. One hundred and thirty consecutive patients with CD (n = 71) and UC (n = 59) were examined. Simple X-rays of lumbar spine, sacroiliac joints, and calcaneal bone were performed and human leukocyte antigen (HLA)-B27 was typed. Joint manifestations occurred in 41 (31.5%) patients, 27 (38%) with CD and 14 (23.7%) with UC. Peripheral involvement occurred in 22 patients, axial involvement in five, and mixed involvement in 14. The most frequently involved joints were knees (56.1%), ankles (29.3%), and hips (29.3%), while the predominant pattern was oligoarticular (84.6%) and asymmetrical (65.6%). Enthesitis was identified in seven (5.4%) patients and inflammatory lumbar pain in 13 (10%). Eight of these patients fulfilled the diagnostic criteria for ankylosing spondylitis (6.2%). Radiographic sacroiliitis occurred in 12 patients (9.2%). Ocular abnormalities were present in six patients (6.2%), and HLA-B27 was positive in five (5.8%). In conclusion, the articular manifestations in the present study were predominantly oligoarticular and asymmetric, with a low frequency of ophthalmologic involvement and positive HLA-B27.

Clinical features and epidemiology of spondyloarthritides associated with inflammatory bowel disease

“…Studies on IBD populations after the introduction of the ESSG criteria or Amor criteria are summarized in Table 6 [1, [34][35][36][37][38][39][40][41][42][43][44][45] . A discrete number of papers reporting on IBD-associated joint disease were not included.…”

“…Puerto Rico 100 2.6 13 5 42 42 --Lanna [45] Only symptomatic SI, X-ray assessment; Undefined arthralgia group; no definitions are given for spondylitis or arthritis;…”

25 Incidence of Spondyloarthropathy in Patients With Ulcerative Colitis: A Population-Based Study

“…Estimates of spondyloarthritis (SpA) prevalence in IBD are available from several cohorts, but none have been reported in US populations, and no population-based incidence estimates are available from any established cohort (1,3,(8)(9)(10)(11)(12)(13). Our aim was to assess the prevalence and cumulative incidence of spondyloarthritis in a population-based cohort of UC patients from Olmsted County, Minnesota.…”

Injury to the joint and spinal column in patients with inflammatory bowel diseases

“…Эпидемиоло-гические исследования, посвященные периартикулярной патологии при ВЗК, проводились редко, по имеющимся данным, ее распространенность оценивается в 1,5-5,4% [57,63]. В одном из таких исследований, выполненном K. Al-Jarallah и соавт.…”

“…Лечение именно этой категория больных наиболее сложная проблема. Невозможность длительного назначения НПВП в терапевтических дозах и неэффектив-ность СУЛЬФ диктуют целесообразность раннего примене-ния генно-инженерных биологических препаратов (ГИБП), относящихся к классу антител к ФНОα [63]. В настоящее время накоплен положительный опыт лечения СпА у паци-ентов с ВЗК инфликсимабом и адалимумабом [30,65].…”