A cross-sectional hospital-based study of autoantibody profile and clinical manifestations of systemic lupus erythematosus in south Indian patients

Abstract

Our study was aimed to analyze clinical manifestations, autoantibodies and other serological abnormalities in South Indian patients with systemic lupus erythematosus. Clinical history and findings on systemic examination were noted. Antinuclear antibodies (ANA), antibodies to double-stranded DNA (dsDNA) were detected by immunofluorescence and ANA profile by Immunoblotting. Arthritis was most common followed by fever and skin rash. Clinical manifestations vary according to geographical location of the patient. ANA was positive in 64.28% and anti-dsDNA in 89.36% of patients. All patients with lupus nephritis were positive for dsDNA. Detection of antibodies to dsDNA, RNP and anti-Smith (Sm) are of diagnostic and prognostic importance.

Study on Clinical Manifestations of SLE and its Anti-Nuclear Antibodies Profile

“…Kosaraju K et al and Paul BJ et al among south indian patients also reported that arthritis was the most common manifestation. [9,10] In accordance to this study Kosarju K et al has reported malar rash and vasculitis ulcers not frequently observed. [9] They also mentioned that there is very less observance of raynauds phenomenon.…”

“…[9,10] In accordance to this study Kosarju K et al has reported malar rash and vasculitis ulcers not frequently observed. [9] They also mentioned that there is very less observance of raynauds phenomenon. Nephritis is most commonly observed among south east asian patients than in Indian patients.…”

“…[14] In this study Positivity of ANA was shown in 65.6% SLE patients. Kosaraju K et al [9] showed ANA positivity of 64.28% and anti-ds DNA positivity was 89.36%. Koel et al [12] also reported anti ds DNA antibodies were most commonly reported (83.3%).…”

“…Nephritis is most commonly observed among south east asian patients than in Indian patients. [9] Butterfly rash was observed as 20.9% and 80% by Dubois et al [11] and Koel et al respectively. [12] Yell et al reported that the maculopapular lesions was 45% and 31.5% of oral ulcers.…”

2.7 Systemic lupus erythematosus, Sjogren's and antiphospholipid syndrome – clinical aspects, comorbidities and complications

“…Antibodies data above in GC-positive and GCnegative patients are 140. 5 Conclusion: In this pilot study, there seems to be no difference of GC-like structure in pSS and sSS's salivary glands. GC structure is particularly noted in patients with higher focus score.…”