A Cross Sectional Clinical Study to Assess the Influence of Chronic Proton Pump Inhibitor Therapy on Serum Magnesium Levels

Abstract

Introduction: Proton pump inhibitors (PPI) are the drugs, most commonly used in the treatment of acid peptic diseases like gastric, duodenal ulcers, gastro-esophageal reflux disease, gastritis and Zollinger Ellison syndrome. Though they have good clinical safety profile, few adverse effects have been reported with chronic use of PPI. Hypomagnesemia is one of the adverse effects associated with long term PPI use.Hence, this study was conducted to identify the implication of long term PPI therapy on serum magnesium (Mg).Methods: It was a cross sectional, clinical study involving 60 participants in three groups. Group I included 20 subjects who were on PPI for 45 to 60 days. Group II had 20 subjects on PPI for more than 1 year. Group III (Control) had 20 subjects not on PPI. Results: Demographic data, height, weight, BMI, pulse rate and blood pressure were recorded and serum magnesium was estimated.The mean serum Mg level was found to be 2.28±0.32mg/dL in control group, 1.82±0.12mg/dl in Group I and 1.63±0.24mg/dl in Group II. One way ANOVA followed by Tukey post-hoc test was used to evaluate the difference in serum Mg levels between the groups. The difference noted in Groups I and II in comparison with Control group was statistically significant. Conclusion: This study