A cross-sectional, case-control follow-up of infants with gastroschisis

Payne, Nathaniel R.; Gilmore, Lois; Svobodny, Stacy; Perdue, Nina R.; Hoekstra, Ronald; Olsen, Sam; Moore, James R.

doi:10.3233/npm-2010-0117

Cited by 8 publications

(8 citation statements)

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“…Late preterm birth has also been associated with adverse cognitive and socioemotional outcomes [ 39 ]. Gastroschisis patients warrant close monitoring for developmental and intellectual problems throughout childhood [ 40 , 41 ].…”

Section: Discussionmentioning

confidence: 99%

Growth restriction in gastroschisis: quantification of its severity and exploration of a placental cause

et al. 2011

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BackgroundGastroschisis patients are commonly small for gestational age (SGA, birth weight [BW] < 10th centile). However, the extent, symmetry and causes of that growth restriction remain controversial.MethodsWe compared BW, crown-heel length (LT), occipitofrontal circumference (OFC) and ponderal index (PI) in 179 gastroschisis cases and 895 matched controls by univariate and multiple regression. Fetal ultrasounds (N = 80) were reviewed to determine onset of growth restriction. Placental histology was examined in 31 gastroschisis patients whose placental tissue was available and in 29 controls.ResultsGastroschisis cases weighed less than controls (BW = 2400 ± 502 g vs. 2750 ± 532 g, p < 0.001) and their BW frequency curve was shifted to the left, indicating lower BW as a group compared to controls (p < 0.001 by Kolmogorov-Smirnov test). BW differences varied from -148 g at 33 weeks to -616 g at 38 weeks gestation. Intrauterine growth restriction was symmetric with gastroschisis patients having a shorter LT (45.7 ± 3.3 vs. 48.4 ± 2.7 cm, p < 0.001), smaller OFC (31.9 ± 1.9 vs. 32.9 ± 1.6 cm, p < 0.001), but larger ponderal index (2.51 ± 0.37 vs. 2.40 ± 0.16, p < 0.001) compared to controls. Gastroschisis patients had a similar reduction in BW (-312 g, 95% confidence interval [CI] = -367, -258) compared to those with chromosomal abnormalities (-239 g, CI = -292, -187). Growth deficits appeared early in the second trimester and worsened as gestation increased. Placental chorangiosis was more common in gastroschisis patients than controls, even after removing all SGA patients (77% vs. 42%, p = 0.02).ConclusionsMarked, relatively symmetric intrauterine growth restriction is an intrinsic part of gastroschisis. It begins early in the second trimester, and is associated with placental chorangiosis.

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Section: Discussionmentioning

confidence: 99%

Growth restriction in gastroschisis: quantification of its severity and exploration of a placental cause

et al. 2011

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“…Ten studies were included in the school age group (6 years-17 years 11 months). 41,[58][59][60][61][62][63][64][65][66] Cognitive and intellectual development once again demonstrated conflicting findings, similar to results in the infant/toddler age range. Some studies (n ¼ 4) evaluating cohorts inclusive of children with GS found that overall intellectual functioning was consistent with population norms.…”

Section: School Agementioning

confidence: 54%

“…33,38,41,44 50,51,54-57 Studies in the cognitive/intellectual developmental domain (n ¼ 7) demonstrated that various study cohorts (all of which include children with GS) performed similarly to the normative population. 33,38,41,44,[54][55][56] The very limited data on the communication/language domain in the preschool age group demonstrated no significant differences from the normative population. Burnett et al in 2018 evaluated children with abdominal wall defects (i.e., GS and omphalocele) at 2 (BSID-III) and 5 (WPPSI-III) years of age and found that the study cohort performed similarly to the normative data at both time points.…”

Section: Infant/toddler Age Groupmentioning

confidence: 85%

“…Fourteen studies evaluating assorted cohorts inclusive of children with GS (e.g., children that underwent neonatal cardiac or noncardiac surgery, children with intestinal failure [IF that results from most commonly necrotizing enterocolitis, GS, atresia, volvulus, and Hirschsprung disease], children born with congenital anomalies, or specifically children with GS) found that these children performed similarly to the normative data or, if included, healthy controls, and exhibited no signs of neurodevelopmental deficit. [31][32][33][34][35][36][37][38][39][40][41][42][43][44] Contrarily, other studies (n ¼ 5) demonstrated that similar cohorts have significantly worse cognitive/intellectual development scores, as estimated by the Mental Developmental Index of the BSID-III 45,46 and the general quotient and mental age categories on the Griffiths Mental Developmental Scales (GMDS) 47 than the normative data and/or healthy controls. [45][46][47][48][49] Specifically, one of these studies found that general cognitive level on the BSID-III significantly decreased from 12 to 24 months.…”

Section: Infant/toddler Age Groupmentioning

confidence: 99%

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Long-Term Neurodevelopmental Outcomes in Children with Gastroschisis: A Review of the Literature

Rundell,

Bailey,

Wagner

et al. 2024

Am J Perinatol

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This study aimed to investigate and present a review of the literature on long-term neurodevelopmental outcomes in children with gastroschisis. Gastroschisis is the most common abdominal wall defect. Children with gastroschisis are at high risk for premature birth, intestinal failure, sepsis, and repeated anesthesia exposure, which collectively increase the risk for adverse long-term neurodevelopmental outcomes. The existing literature on neurodevelopmental outcomes is limited in number, quality, and generalizability, creating a gap in clinical knowledge and care. Five internet databases were searched by a professional research librarian: Ovid MEDLINE, Scopus, Web of Science, PsycINFO, and Cochrane Library. Included articles were (1) published in English, (2) included postneonatal hospital discharge neurodevelopmental outcomes of children with gastroschisis, and (3) included patients under the age of 18 years. No date parameters were applied. The paucity of literature on long-term neurodevelopmental outcomes in gastroschisis children has left large gaps in the body of knowledge on post-hospital care of such children. In this review, 37 articles were found evaluating neurodevelopmental outcomes in gastroschisis and, while conclusions were contradictory, the literature broadly indicated the potential for neurodevelopmental deficits in the gastroschisis pediatric population. A significant limitation of this review was the heterogeneous samples included in available literature, which confounded the ability to determine cognitive risk of gastroschisis independent of other abdominal wall defects. Findings of this review demonstrate potential risk for neurodevelopmental deficits in the pediatric gastroschisis population exist, yet additional research is needed to definitively predict the significance, type, onset, and trajectory of neurodevelopmental impairment in this population. The significant gaps in long-term outcomes data have elucidated the need for prospective, longitudinal investigation of various cognitive domains in homogenous gastroschisis populations to properly evaluate prevalence of neurodevelopmental deficits and guide recommendations for long-term clinical care. Key Points

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“…In total, 99 studies reported on small bowel obstruction entailing 8,470 patients and 572 events of SBO all anomalies combined [ 10 , 11 , 14 ], [ 15 ], [ 16 ], [ 17 ], [ 18 ], [ 19 , 21 , 24 , 26 , 29 ], [ 30 ], [ 31 , 33 , 34 , 37 ], [ 38 ], [ 39 ], [ 40 ], [ 41 , 43 , 45 , 47 , 49 , 51 ], [ 52 ], [ 53 ], [ 54 , 56 ], [ 57 ], [ 58 ], [ 59 ], [ 60 , 62 , 63 , 67 , 70 ], [ 71 ], [ 72 ], [ 73 ], [ 74 , 79 ], [ 80 ], [ 81 , 85 ], [ 86 ], [ 87 ], [ 88 ], [ 89 , 92 ]...…”

Section: Resultsmentioning

confidence: 99%

The incidence of different forms of ileus following surgery for abdominal birth defects in infants: a systematic review with a meta-analysis method

Schattenkerk

Musters

Nijssen

et al. 2021

Innovative Surgical Sciences

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Objectives Ileus following surgery can arise in different forms namely as paralytic ileus, adhesive small bowel obstruction or as anastomotic stenosis. The incidences of these different forms of ileus are not well known after abdominal birth defect surgery in infants. Therefore, this review aims to estimate the incidence in general between abdominal birth defects. Content Studies reporting on paralytic ileus, adhesive small bowel obstruction or anastomotic stenosis were considered eligible. PubMed and Embase were searched and risk of bias was assessed. Primary outcome was the incidence of complications. A meta-analysis was performed to pool the reported incidences in total and per birth defect separately. Summary This study represents a total of 11,617 patients described in 152 studies of which 86 (56%) had a follow-up of at least half a year. Pooled proportions were calculated as follows; paralytic ileus: 0.07 (95%-CI, 0.05–0.11; I 2=71%, p≤0.01) ranging from 0.14 (95% CI: 0.08–0.23) in gastroschisis to 0.05 (95%-CI: 0.02–0.13) in omphalocele. Adhesive small bowel obstruction: 0.06 (95%-CI: 0.05–0.07; I 2=74%, p≤0.01) ranging from 0.11 (95% CI: 0.06–0.19) in malrotation to 0.03 (95% CI: 0.02–0.06) in anorectal malformations. Anastomotic stenosis after a month 0.04 (95%-CI: 0.03–0.06; I 2=59%, p=0.30) ranging from 0.08 (95% CI: 0.04–0.14) in gastroschisis to 0.02 (95% CI: 0.01–0.04) in duodenal obstruction. Anastomotic stenosis within a month 0.03 (95%-CI 0.01–0.10; I 2=81%, p=0.02) was reviewed without separate analysis per birth defect. Outlook This review is the first to aggregate the known literature in order approximate the incidence of different forms of ileus for different abdominal birth defects. We showed these complications are common and the distribution varies between birth defects. Knowing which birth defects are most at risk can aid clinicians in taking prompt action, such as nasogastric tube placement, when an ileus is suspected. Future research should focus on the identification of risk factors and preventative measures. The incidences provided by this review can be used in those studies as a starting point for sample size calculations.

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A cross-sectional, case-control follow-up of infants with gastroschisis

Cited by 8 publications

References 0 publications

Growth restriction in gastroschisis: quantification of its severity and exploration of a placental cause

Growth restriction in gastroschisis: quantification of its severity and exploration of a placental cause

Long-Term Neurodevelopmental Outcomes in Children with Gastroschisis: A Review of the Literature

The incidence of different forms of ileus following surgery for abdominal birth defects in infants: a systematic review with a meta-analysis method

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