A Critical Role of Brain-Derived Neurotrophic Factor in Alcohol Consumption

Pandey, Subhash C.

doi:10.1016/j.biopsych.2015.12.020

Cited by 29 publications

(23 citation statements)

References 11 publications

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“…Expression of BDNF in various brain regions has been found to mediate alcohol drinking behavior in rodents (Pandey, 2016). Indeed, innate BDNF expression is increased in the VTA of alcohol-avoiding rats (Raivio, Miettinen, & Kiianmaa, 2014).…”

Section: Discussionmentioning

confidence: 99%

Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background

Rompala

Finegersh

Slater

et al. 2017

Alcohol

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While alcohol use disorder (AUD) is a highly heritable condition, the basis of AUD in families with a history of alcoholism is difficult to explain by genetic variation alone. Emerging evidence suggests that parental experience prior to conception can impact inheritance of complex behaviors in offspring via non-genomic (epigenetic) mechanisms. For instance, male C57BL/6J (B6) mice exposed to chronic intermittent vapor ethanol (CIE) prior to mating with Strain 129S1/SvImJ ethanol-naïve females produce male offspring with reduced ethanol drinking preference, increased ethanol sensitivity, and increased BDNF expression in the ventral tegmental area (VTA). In the present study, we tested the hypothesis that these intergenerational effects of paternal CIE are reproducible in male offspring on an inbred B6 background. To this end, B6 males were exposed to six weeks of CIE (or room air as a control) before mating with ethanol-naïve B6 females to produce ethanol (E)-sired and control (C)-sired male and female offspring. We observed a sex-specific effect, as E-sired males exhibited decreased two bottle free-choice ethanol drinking preference, increased sensitivity to the anxiolytic effects of ethanol, and increased VTA BDNF expression; no differences were observed in female offspring. These findings confirm and extend our previous results by demonstrating that the effects of paternal preconception ethanol are reproducible using genetically identical, inbred B6 animals.

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Section: Discussionmentioning

confidence: 99%

Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background

Rompala

Finegersh

Slater

et al. 2017

Alcohol

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“…Brain-derived neurotrophic factor (BDNF) has a well-known role in synaptic plasticity, and has been implicated in response to multiple drugs of abuse (Barker et al, 2015). BDNF expression has been shown to mediate alcohol drinking behaviors in rodents (Pandey, 2016), with increased BDNF in the ventral tegmental area (VTA) resulting in decreased alcohol consumption (Raivio et al, 2014). Alcohol-sired male 129Sv/ImJ 9 C57BL/6J mice and C57BL/6J mice showed increased Bdnf mRNA expression in the VTA (Finegersh & Homanics, 2014;Rompala et al, 2017), which may underlie the observed decrease in alcohol consumption.…”

Section: Alcoholmentioning

confidence: 99%

Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

Goldberg

Gould

2018

Eur J of Neuroscience

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Addictions are highly heritable disorders, with heritability estimates ranging from 39% to 72%. Multiple studies suggest a link between paternal drug abuse and addiction in their children. However, patterns of inheritance cannot be explained purely by Mendelian genetic mechanisms. Exposure to drugs of abuse results in epigenetic changes that may be passed on through the germline. This mechanism of epigenetic transgenerational inheritance may provide a link between paternal drug exposure and addiction susceptibility in the offspring. Recent studies have begun to investigate the effect of paternal drug exposure on behavioral and neurobiological phenotypes in offspring of drug-exposed fathers in rodent models. This review aims to discuss behavioral and neural effects of paternal exposure to alcohol, cocaine, opioids, and nicotine. Although a special focus will be on addiction-relevant behaviors, additional behavioral effects including cognition, anxiety, and depressive-like behaviors will be discussed.

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“…A recent study suggested that female offspring of parents with a history of alcohol dependence exhibit a lower reward dependence score in association with the presence of the Val66Met polymorphism, and this may modulate their vulnerability to depression (Benzerouk et al, 2015). It has also been demonstrated that mice carrying the Val68Met polymorphism have a higher risk of developing uncontrolled and excessive alcohol drinking patterns (Warnault et al, 2016; Pandey, 2016). …”

Section: Common Molecules Of Alcohol Addiction and Stressmentioning

confidence: 99%

Epigenetic mechanisms of alcoholism and stress-related disorders

Palmisano

Pandey

2017

Alcohol

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Stress-related disorders, such as anxiety, early life stress and posttraumatic stress disorder appear to be important factors in promoting alcoholism, as alcohol consumption can temporarily attenuate the negative affective symptoms of these disorders. Several molecules involved in signaling pathways may contribute to the neuroadaptation induced during alcohol dependence and stress disorders, and among these, brain-derived neurotrophic factor (BDNF), corticotropin releasing factor (CRF), neuropeptide Y (NPY) and opioid peptides (i.e. nociceptin and dynorphin) are involved in the interaction of stress and alcohol. In fact, alterations in the expression and function of these molecules have been associated with the pathophysiology of stress-related disorders and alcoholism. In recent years, various studies have focused on the epigenetic mechanisms that regulate chromatin architecture thereby modifying gene expression. Interestingly, epigenetic modifications in specific brain regions have been shown to be associated with the neurobiology of psychiatric disorders, including alcoholism and stress. In particular, the enzymes responsible for chromatin remodeling (i.e. histone deacetylases and methyltransferases, DNA methyltransferases) have been identified as common molecular mechanisms for the interaction of stress and alcohol and have become promising therapeutic targets to treat or prevent alcoholism and associated emotional disorders.

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A Critical Role of Brain-Derived Neurotrophic Factor in Alcohol Consumption

Cited by 29 publications

References 11 publications

Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background

Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background

Multigenerational and transgenerational effects of paternal exposure to drugs of abuse on behavioral and neural function

Epigenetic mechanisms of alcoholism and stress-related disorders

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