A Critical Review on the Pharmacodynamics and Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs and Opioid Drugs Used in Reptiles

Ting, Allison Kah Yann; Tay, Vanessa Shu Yu; Chng, Hui Ting; Xie, Shangzhe

doi:10.1016/j.vas.2022.100267

Cited by 2 publications

(2 citation statements)

References 96 publications

(221 reference statements)

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“…In other drug classes, namely nonsteroidal anti-inflammatories and opioids, squamates tend to have higher drug clearances than chelonians. 34 This study underscores the continued need to conduct species-specific pharmacokinetic studies in reptiles rather than relying on dose extrapolation between species.…”

Section: Discussionmentioning

confidence: 89%

“…The physiological processes of reptiles are temperature dependent and can contribute to varied drug disposition among individuals. 34 Animals in our study were maintained in temperatures from 26.9 to 31.6°C. Existing pharmacokinetic studies of CCFA in reptiles maintained housing temperatures of 26.1°C, 30°C, and 30°C for ball pythons, green iguanas, and bearded dragons, respectively.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pharmacokinetics of Single Intramuscular Administration of Ceftiofur Crystalline Free Acid in American Alligators (Alligator Mississippiensis)

Cashin,

Martinez,

Magnin

et al. 2024

Journal of Zoo and Wildlife Medicine

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of Single Intramuscular Administration of Ceftiofur Crystalline Free Acid in American Alligators (Alligator Mississippiensis)

Cashin,

Martinez,

Magnin

et al. 2024

Journal of Zoo and Wildlife Medicine

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Egg Removal via Cloacoscopy in Three Dystocic Leopard Geckos (Eublepharis macularius)

Vetere

Bigliardi

Masi³

et al. 2023

Animals

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Dystocia is a multifactorial, life-threatening condition commonly affecting pet reptiles. Treatment for dystocia can be either medical or surgical. Medical treatment usually involves the administration of oxytocin, but in some species or, in some cases, this treatment does not work as expected. Surgical treatments such as ovariectomy or ovariosalpingectomy are resolutive, but invasive in small-sized reptiles. In this paper, we describe three cases of post ovulatory egg retention in three leopard geckos (Eublepharis macularius) successfully treated through a cloacoscopic removal of the retained eggs, after a non resolutive medical treatment. The intervention was fast, non-invasive, and no procedure-related adverse effects were noted. The problem relapsed six months later in one animal, and a successful bilateral ovariosalpingectomy was performed. Cloacoscopy should be considered a valuable, non-invasive tool for egg removal in dystocic leopard geckos when the egg is accessible to manipulation. Recrudescence or complications such as adhesions, oviductal rupture, or the presence of ectopic eggs should recommend surgical intervention.

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A Critical Review on the Pharmacodynamics and Pharmacokinetics of Non-steroidal Anti-inflammatory Drugs and Opioid Drugs Used in Reptiles

Cited by 2 publications

References 96 publications

Pharmacokinetics of Single Intramuscular Administration of Ceftiofur Crystalline Free Acid in American Alligators (Alligator Mississippiensis)

Pharmacokinetics of Single Intramuscular Administration of Ceftiofur Crystalline Free Acid in American Alligators (Alligator Mississippiensis)

Egg Removal via Cloacoscopy in Three Dystocic Leopard Geckos (Eublepharis macularius)

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