A critical review on quantum dots: From synthesis toward applications in electrochemical biosensors for determination of disease-related biomolecules

Farzin, Mohammad Ali; Abdoos, Hassan

doi:10.1016/j.talanta.2020.121828

Cited by 139 publications

(79 citation statements)

References 143 publications

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“…Many techniques were developed to detect neurotransmitters in real samples. Electrochemical sensors were thought of as the most applicable detecting approach in clinics for its advantages including cheapness, simplicity and the fact that they are highly selective and sensitive and easy to miniaturize as shown in Figure 6 [ 113 ]. Herein, in this review, we focused on the latest strategies of CDs based electrochemical biosensors for detecting depression-related neurotransmitters.…”

Section: Discussionmentioning

confidence: 99%

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A Critical Review of Carbon Quantum Dots: From Synthesis toward Applications in Electrochemical Biosensors for the Determination of a Depression-Related Neurotransmitter

Tao

et al. 2021

Materials

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Depression has become the leading cause of disability worldwide and is a global health burden. Quantitative assessment of depression-related neurotransmitter concentrations in human fluids is highly desirable for diagnosis, monitoring disease, and therapeutic interventions of depression. In this review, we focused on the latest strategies of CD-based electrochemical biosensors for detecting a depression-related neurotransmitter. We began this review with an overview of the microstructure, optical properties and cytotoxicity of CDs. Next, we introduced the development of synthetic methods of CDs, including the “Top-down” route and “Bottom-up” route. Finally, we highlighted detecting an application of CD-based electrochemical sensors in a depression-related neurotransmitter. Moreover, challenges and future perspectives on the recent progress of CD-based electrochemical sensors in depression-related neurotransmitter detection were discussed.

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Section: Discussionmentioning

confidence: 99%

“…Figure 6. An ideal feature of an electrochemical sensor in clinics (Reproduced with permission from ref [113]…”

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confidence: 99%

A Critical Review of Carbon Quantum Dots: From Synthesis toward Applications in Electrochemical Biosensors for the Determination of a Depression-Related Neurotransmitter

Tao

et al. 2021

Materials

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“…For the exploration of new sensitive platforms, a strong tendency toward biomolecules, high surface area, and good electrical conductivity is essential [22]. Generally, the signal amplification in the electrochemical biosensors can be achieved by using nanomaterials, such as quantum dots [23,24], metal nanoparticles [2,23], and graphene [2]. The conjugation of PAMAM functionalized nanomaterials with the DNA strands provides efficient nanocomposites for sensing purposes [25,26].…”

Section: Introductionmentioning

confidence: 99%

A nanoscale genosensor for early detection of COVID-19 by voltammetric determination of RNA-dependent RNA polymerase (RdRP) sequence of SARS-CoV-2 virus

Farzin¹,

Sadjadi²,

Sheini³

et al. 2021

Microchim Acta

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Graphical abstract A voltammetric genosensor has been developed for the early diagnosis of COVID-19 by determination of RNA-dependent RNA polymerase (RdRP) sequence as a specific target of novel coronavirus. The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) uses an RdRP for the replication of its genome and the transcription of its genes. Here, the silver ions (Ag + ) in the hexathia-18-crown-6 (HT18C6) were used for the first time as a redox probe. Then, the HT18C6(Ag) incorporated carbon paste electrode (CPE) was further modified with chitosan and PAMAM dendrimer-coated silicon quantum dots (SiQDs@PAMAM) for immobilization of probe sequences (aminated oligonucleotides). The current intensity of differential pulse voltammetry using the redox probe was found to decrease with increasing the concentration of target sequence. Based on such signal-off trend, the proposed genosensor exhibited a good linear response to SARS-CoV-2 RdRP in the concentration range 1.0 pM–8.0 nM with a regression equation I (μA) = − 6.555 log [RdRP sequence] (pM) + 32.676 ( R 2 = 0.995) and a limit of detection (LOD) of 0.3 pM. The standard addition method with different spike concentrations of RdRP sequence in human sputum samples showed a good recovery for real sample analysis (> 95%). Therefore, the developed voltammetric genosensor can be used to determine SARS-CoV-2 RdRP sequence in sputum samples. PAMAM-functionalized SiQDs were used as a versatile electrochemical platform for the SARS-CoV-2 RdRP detection based on a signal off sensing strategy. In this study, for the first time, the silver ions (Ag + ) in the hexathia-18-crown-6 carrier were applied as an electrochemical probe. Supplementary Information The online version contains supplementary material available at 10.1007/s00604-021-04773-6.

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“…Graphene quantum dots (GQDs) or zero-dimensional (0D) graphene are the latest high-value addition to the family of carbon nanomaterials (Li et al, 2016a;Li et al, 2016b;Yan et al, 2018;Yan et al, 2019). As planar and 0D nanocarbons with atomic layer thickness, nanometer wide, and sp (Wang et al, 2017) carbon domain, GQDs have unique characteristics (Ali and Hassan, 2021;Kadian et al, 2021;Pierrat and Gaumet, 2021). For example, their ultrasmall size leads to abundant active edge sites and excellent water dispersibility (Lu et al, 2018;Zhao et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Sensitive Detection of Sulfide Ion Based on Fluorescent Ionic Liquid–Graphene Quantum Dots Nanocomposite

et al. 2021

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Sulfide ions (S2−) that are widely distributed in biological and industrial fields are extremely toxic and pose great harms to both ecological environment and human health. However, fluorescent sensors toward S2− ions commonly use S2−-recovered fluorescence of fluorophore that is first quenched mainly by metal ions. Fluorescent probe which enables direct, selective, and sensitive detection of S2− ion is highly desirable. Herein, we demonstrate one-step preparation of fluorescent ionic liquid–graphene quantum dots (IL-GQDs) nanocomposite, which can act as a fluorescent probe for direct and sensitive detection of S2− ion. The IL-GQDs nanocomposite is easily synthesized via facile molecular fusion of carbon precursor and in situ surface modification of GQDs by IL under hydrothermal condition. The as-prepared IL-GQDs nanocomposite has uniform and ultrasmall size, high crystallinity, and bright green fluorescence (absolute photoluminescence quantum yield of 18.2%). S2− ions can strongly and selectively quench the fluorescence of IL-GQDs because of the anion exchange ability of IL. With IL-GQDs nanocomposite being fluorescent probe, direct and sensitive detection of S2− is realized with a linear detection range of 100nM–10μM and 10μM–0.2mM (limit of detection or LOD of 23nM). Detection of S2− ions in environmental river water is also achieved.

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A critical review on quantum dots: From synthesis toward applications in electrochemical biosensors for determination of disease-related biomolecules

Cited by 139 publications

References 143 publications

A Critical Review of Carbon Quantum Dots: From Synthesis toward Applications in Electrochemical Biosensors for the Determination of a Depression-Related Neurotransmitter

A Critical Review of Carbon Quantum Dots: From Synthesis toward Applications in Electrochemical Biosensors for the Determination of a Depression-Related Neurotransmitter

A nanoscale genosensor for early detection of COVID-19 by voltammetric determination of RNA-dependent RNA polymerase (RdRP) sequence of SARS-CoV-2 virus

Sensitive Detection of Sulfide Ion Based on Fluorescent Ionic Liquid–Graphene Quantum Dots Nanocomposite

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