A critical review on neonatal hyperbilirubinemia-an Ayurvedic perspective

Rathore, Shubhangi; Vk, Chethan Kumar; Sharashchandra, R

doi:10.1016/j.jaim.2018.08.006

Cited by 12 publications

(9 citation statements)

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“…Neonatal hyperbilirubinemia a common disease among early newborns; it is also called neonatal jaundice. Approximately 60%-80% of newborns develop jaundice in the first week after birth [ 1 , 2 ]. The main manifestation is yellowish staining of the sclera and skin when the bilirubin exceeds the normal range, especially when the total bilirubin level rises above 5 mg/dl [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

et al. 2021

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Objective Hyperbilirubinemia is a common disease in the neonatal period, and hyperbilirubinemia may cause brain damage. Therefore, prevention and diagnosis and management of hyperbilirubinemia is very important, and vitamin D may affect bilirubin levels. To evaluate the relationship between neonatal hyperbilirubinemia and vitamin D levels. Method The China National Knowledge Infrastructure, VIP, Wanfang, Chinese Biology Medicine Disc, PubMed, Web of Science, Cochrane Library, and Embase databases as well as clinical trial registries in China and the United States were searched for relevant studies from inception to September 2020 without restrictions on language, population, or year. The studies was screened by two reviewers independently, the data were extracted, and the risk of bias of the included studies was evaluated using the NOS. A meta-analysis was conducted on the included studies using Stata11 software. Results Six case-control studies were included, and the methodological quality of the studies was high (grade A). The studies included 690 newborns; more than 409 were diagnosed with hyperbilirubinemia. The means and standard deviations were calculated. Meta-analysis results showed that neonatal vitamin D levels were 7.1 ng/ml lower among infants with hyperbilirubinemia than among healthy newborn levels (z = 6.95, 95% CI 9.10 ~ 5.09, P < 0.05). Subgroup analysis was conducted based on whether the bilirubin levels were concentrated in the 15 to 20 mg/dl range. Vitamin D level of infants with hyperbilirubinemia (the bilirubin levels were concentrated in the 15 to 20 mg/dl range) was 9.52 ng/ml (Z = 15.55, 95% CI-10.72~-8.32, P<0.05) lower than that of healthy infants. The bilirubin levels in four cases were not concentrated in the 15–20 mg/dl range. The results showed that the vitamin D level of hyperbilirubinemia (The bilirubin levels were not concentrated in the 15–20 mg/dl range) neonates were 5.35 ng/ml lower than that of healthy neonates (Z = 6.43, 95% CI-6.98~-3.72, P<0.05). Conclusion Vitamin D levels were observed to be lower in neonates with hyperbilirubinemia as compared to term neonates without hyperbilirubinemia in this study. This can possibly suggest that neonates with lower vitamin D levels are at higher risk for developing hyperbilirubinemia.

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Section: Introductionmentioning

confidence: 99%

Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

et al. 2021

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“…Also, in pittajavikara, Virechana is the main principle of treatment. Acharyas mentioned anulomana(correcting Vata's direction) and Mruduvirechaka(mild purgative) in Kamala and Pittaja Vikaara virechana karma medications" (Rathore et al, 2020).…”

Section: Assessment Of Treatmentmentioning

confidence: 99%

Clinical evaluation of Nitya Virechana in Hepato cellular Jaundice – A Case Study

Parwe

Nisargandha

2020

ijrps

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Kamala is a Vikar of the pittapradoshja. The symptoms are analogous to those of jaundice. Hepatocellular jaundice is an infectious condition which affects the liver.Due to lifestyle modification, society can't follow these concepts about ‘Aahar’&Vihar’(Diet and behavioural regime)(e.g. fast food, Chinese style food, late-night sleep and day sleep. So now the maximum people in a day are going to suffer from GIT problem. Pittakar-ahar likes Vada-Pav, highly spiced food and propensity to consume alcohol is also rising gradually. Ayurveda has historically been highly proficient and has been treating liver disorders for centuries, and the drug toxicity tends to be lower than conventional medicine. Therefore the case study, like NityaVirechana, is based on Ayurvedic Medicine and Purification Therapy (Panchakarma Procedure). Acharya Charak stated the Classical Virechana is management, but the patient was lean, and his strength was not as much of, so incapable of performing classical virechan. His body structure and his strength and working pattern kept in mind, we planned Nityavirechan (daily purgation) and got a very good outcome and also saved his time for hospitalisation.

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“…This condition is clinically called "hyperbilirubinemia." 4 Hyperbilirubinemia is normally treated using three methods: blood exchange therapy, 5 intense light treatment, 6 and hemoperfusion. 7 Because of the high cost of blood exchange therapy, the low inefficiency of hemodialysis to remove bilirubin, and the long period of intense light treatment, clinically, hemoperfusion (S1) is frequently used to treat hyperbilirubinemia.…”

Section: Introductionmentioning

confidence: 99%

“…When the patient’s bilirubin level reaches 20 mg/dL, it will cause irreversible damage to the human brain and nervous system, and the high concentration of bilirubin accumulated rapidly in the patient’s body cannot be excreted in time, and the patient is at risk of death at any time. This condition is clinically called “hyperbilirubinemia.”…”

Section: Introductionmentioning

confidence: 99%

MXene Nanosheet-Enhanced Chitin Aerogel Spheres for Bilirubin Adsorption

Zhang

Shao

et al. 2022

ACS Appl. Nano Mater.

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Excessive bilirubin in human blood can cause irreversible damage to the patient’s brain and nervous system. Herein, chitin/MXene (Ch/MX) composite aerogel spheres were designed by supercritical CO2 technology to remove bilirubin safely, quickly, and efficiently. In this study, Ti3C2 with 4 nm thickness was uniformly dispersed in the chitin fibers as a monolayer nanofiller and tightly connected with the chitin fibers, which significantly improved the mechanical strength and adsorption capacity of the aerogel spheres. The Ch/MX aerogel spheres could withstand 25,000 times their own weight. Compared with chitin aerogel spheres, the equilibrium time for bilirubin adsorption by Ch/MX aerogel spheres was shortened by 33% and the adsorption capacity was increased by 40%. In addition, Ch/MX aerogel spheres still possess a high adsorption capacity of 142.86 mg/g in bilirubin solution with BSA protein up to 80 mg/mL. Compared with commercial products used clinically, Ch/MX has the advantages of high adsorption capacity and high interference resistance. Compared with our previous chitinous/graphene aerogel spheres, Ch/MX has the advantages of low dosage of functional materials, high bilirubin adsorption rate, and good biocompatibility. This study demonstrates the advantages of MXene as a nanofiller for adsorbing bilirubin and promotes the development and application of inorganic 2D nanomaterials in the clinical treatment of hyperbilirubinemia.

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A critical review on neonatal hyperbilirubinemia-an Ayurvedic perspective

Cited by 12 publications

References 1 publication

Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

Correlation between neonatal hyperbilirubinemia and vitamin D levels: A meta-analysis

Clinical evaluation of Nitya Virechana in Hepato cellular Jaundice – A Case Study

MXene Nanosheet-Enhanced Chitin Aerogel Spheres for Bilirubin Adsorption

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