A Critical Review on Analytical Methods for Recently Approved FDC Drugs: Pregabalin and Etoricoxib

Shah, Janvi; Kotadiya, Rajendra

doi:10.1080/10408347.2020.1855411

Cited by 10 publications

(1 citation statement)

References 112 publications

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“…This group was first discovered in 1999 to avoid the side effects that result from using conventional NSAIDs, especially gastrointestinal ones 2 . Etoricoxib, which was developed and introduced into clinical practice in 2002 3 , has the molecular formula C18H15CIN2O2S, with a molecular weight of 358.84 g/mol 4 .…”

Section: Unlikementioning

confidence: 99%

A Validated Rp-HPLC Method for Separation and Determination of Etoricoxib and Paracetamol in Bulk and Pharmaceutical Dosage Form

Ghazal,

Almardini,

Allous

2023

Bulletin of Pharmaceutical Sciences Assiut University

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Etoricoxib is a non-steroidal, anti-inflammatory drug (NSAID) and a selective inhibitor of Cyclooxygenase 2 (COX2), which makes it safer on the gastrointestinal tract than the other NSAIDs. Given the importance of Etoricoxib's, its combination with paracetamol offers higher efficacy and fewer side effects. In addition to the popularity of this combination in the pharmaceutical industry and the diversity of its manufacturing companies, this study aims to develop a novel, precise, selective, rapid and economic assay method for the simultaneous quantitative determination of Etoricoxib and paracetamol in bulk and pharmaceutical dosage form using reverse phase HPLC. This developed method has a short run time of less than 4 minutes using a C18 column (150×4.6) mm 5μm, a mobile phase of methanol and ammonium acetate (pH =3.5) in a ratio (60:40), respectively. The elution was observed at 245 nm using a PDA detector; the retention times of paracetamol and Etoricoxib were found to be 2.493 and 3.64 min, respectively, and a resolution factor larger than 2. Linearity was established with correlation coefficient values of 0.9991, 0.9994 for both Etoricoxib and paracetamol drugs. Precision was within the relative standard deviation of less than 2% for both drugs, and the percentage recoveries were found to be 99.98% and 99.35% for paracetamol and Etoricoxib, respectively. LOD and LOQ of paracetamol were 1.4 g/ml and 4.3 g/ml, respectively, and 0.52 g/ml and 1.6 g/ml for Etoricoxib, respectively. The selectivity test results showed no interference from the tablet excipients during the separation process, which verifies that this method is easily applicable to quality control labs and pharmaceutical industries, in addition to being fast, accurate and cost-effective.

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Section: Unlikementioning

confidence: 99%

A Validated Rp-HPLC Method for Separation and Determination of Etoricoxib and Paracetamol in Bulk and Pharmaceutical Dosage Form

Ghazal,

Almardini,

Allous

2023

Bulletin of Pharmaceutical Sciences Assiut University

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Stability-indicating HPLC for remogliflozin, vildagliptin, and metformin: Method development, validation, and greenness

Acharya,

Kotadiya

2024

Annales Pharmaceutiques Françaises

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Thiazolidinediones: Recent Development in Analytical Methodologies

Patel

2023

Journal of Chromatographic Science

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The instrumental analytical methods that have been developed and utilized for the determination of thiazolidinedione in bulk medications, formulations and biological fluids have been reviewed after an in-depth analysis of the literature published in a variety of analytical and pharmaceutical chemistry-related journals. The approaches covered by this research, which covers the years 2001–2022, include complex methods for analysis, chromatographic techniques and spectrometric analytical procedures. The mobile phase, flow rate, sample matrix, wavelength and other factors identified in the literature were just a few of the parameters used to evaluate thiazolidinediones. The present review focuses on the published analytical techniques for thiazolidinedione analysis that have been previously identified in the literature. The specified outcomes followed extensive learning, and the most recent advances in analytical methods for the identification of pioglitazone, pioglitazone HCl, rosiglitazone, rosiglitazone maleate and lobeglitazone were reviewed. Additionally, this article briefly discusses features of analytical discovery on thiazolidinediones, which will enable readers to access all discoveries in one place with precise outcomes.

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A Critical Review on Analytical Methods for Recently Approved FDC Drugs: Pregabalin and Etoricoxib

Cited by 10 publications

References 112 publications

A Validated Rp-HPLC Method for Separation and Determination of Etoricoxib and Paracetamol in Bulk and Pharmaceutical Dosage Form

A Validated Rp-HPLC Method for Separation and Determination of Etoricoxib and Paracetamol in Bulk and Pharmaceutical Dosage Form

Stability-indicating HPLC for remogliflozin, vildagliptin, and metformin: Method development, validation, and greenness

Thiazolidinediones: Recent Development in Analytical Methodologies

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