A critical review of trials of transcranial direct current stimulation and trigeminal nerve stimulation for depression: the issue of treatment-emergent mania

Shiozawa, Pedro; Cordeiro, Quirino; Cho, Hyong Jin; Trevizol, Alisson Paulino; Brietzke, Elisa

doi:10.1590/2237-6089-2016-0027

Cited by 11 publications

(9 citation statements)

References 39 publications

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“…4 Electroconvulsive therapy offers more long-lasting symptom relief; however, technical challenges and the expense prevent it being as the first-line treatment in daily care. 5 In recent years, there has been growing interest in applying transcranial direct current stimulation (tDCS) for treatment of depression. 6 Results from clinical practices, trials, and some meta-analyses demonstrate favorable potentials for application of tDCS.…”

Section: Introductionmentioning

confidence: 99%

“…12 Treatment-emergent mania has been reported as a possible side effect of tDCS. 5 In a critical review, 7 trials of tDCS were evaluated with a total of 319 participants. Only 9 (5.38%) participants in active tDCS groups with simultaneous antidepressants therapy showed treatment-emergent mania.…”

Section: Introductionmentioning

confidence: 99%

“…However, the importance of safety assessment in further research was emphasized. 5 Few randomized clinical trials have been published recently on the therapeutic effects of tDCS for the treatment of resistant major depression. However, while there are some studies with sufficient power, 13 there are other researches with poor methodological quality, lack of uniformity, and small sample sizes that decrease the generalizability of the conclusions.…”

Section: Introductionmentioning

confidence: 99%

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Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

et al. 2019

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In the current study, we tried to evaluate the effect of transcranial direct current stimulation (tDCS) on treatment-resistant major depression. We carried out a double-blind randomized sham-controlled trial was conducted in University Hospitals. Individuals with less than 50% decrease in the intensity of depression after 8 weeks of treatment with selective serotonin reuptake inhibitors were recruited. Thirty patients (16 women) with a mean (SD) age of 47.2 (12.0) years were randomly allocated to 2 groups. For the active group we administered 2-mA stimulation 20 minutes for each session, with 30 seconds ramp-up from 0 and 30 seconds ramp-down. For the sham group we administered 30 seconds ramp-up to 2 mA, 10 seconds stimulation, 30 seconds ramp-down, and 20 minutes no current. The anode was fixed on the center of F3, and the cathode on F4, over the dorsolateral prefrontal cortex. We assessed the Hamilton Depression Rating Scale at the baseline (mean difference = 1.0, P = .630), at the last session of tDCS, and at 1-month postintervention. There were statistically significant differences in the mean Hamilton scores after the intervention, and 1 month later in favor of active group; P < .001, and P = .003, respectively. Mixed analysis of variance showed a significant difference in the mean scores for active group P = .010 and pattern of change during the study P < .001 in favor of active intervention. We concluded that tDCS is an efficient therapy for patients with resistant major depression, and the benefits would remain at least for 1 month.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

et al. 2019

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“…Trigeminal nerve stimulator (TNS) is the first medical device in ADHD with FDA approval (obtained in 2019) and indicated in children at age 7-12 without ongoing ADHD pharmacotherapy [5]. The use of TNS in neuropsychiatric disorders is not limited to ADHD and includes epilepsy, depression, pain disorders, and migraine [6,7].…”

Section: Main Textmentioning

confidence: 99%

Trigeminal nerve stimulation: a recently approved treatment approach in attention deficit hyperactivity disorder

Çöpür

2021

Egypt J Neurol Psychiatry Neurosurg

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Attention-deficit hyperactivity disorder (ADHD) with its high prevalence is a growing area of concern and research, whereas exact underlying pathophysiology remains unknown. Behavioral therapy and multiple medications include methylphenidate, atomoxetine, and amphetamines while trigeminal nerve stimulator (TNS) is the first medical device in ADHD with FDA approval. The aim of this article is to evaluate the latest studies in this field.

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“…Trigeminal nerve stimulation (TNS) is thought to have neuromodulatory effects on cortical and subcortical regions associated with neuropsychiatric disorders. Studies have shown that TNS may have therapeutic effects on various neuropsychiatric conditions, such as drug‐resistant epilepsy, post‐traumatic distress syndrome, depression, and the negative symptoms of schizophrenia . Thus, hypersensitivity of the trigeminal nerve, which possibly underlies PSS, may also be involved in the emotional regulatory aspects of these neuropsychiatric conditions.…”

Section: Introductionmentioning

confidence: 99%

Possible association between photic sneeze syndrome and migraine and psychological distress

Sasayama

Asano²,

Nogawa³

et al. 2019

Neuropsychopharm Rep

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Background Photic sneeze syndrome (PSS) is a condition that causes sneezing when the eye is exposed to sudden bright light. Because alterations in the parasympathetic and trigeminal nerve systems have been implicated in PSS, and such systems are involved in migraine and stress‐related disorders, we examined the possible associations of PSS with migraine and psychological distress. Methods The presence of PSS and migraine was examined in 11 840 participants from the general population using a self‐report questionnaire. Psychological distress was assessed by the 6‐item Kessler Psychological Distress Scale (K6). Results The overall prevalence of PSS was 3.1%. Individuals with PSS were more likely to suffer from migraine (odds ratio = 1.97, P = 2.18 × 10–9), clinically relevant psychological distress (K6 score ≥ 5: odds ratio = 1.40, P = 0.00143), and severe psychological distress (K6 score ≥ 13: odds ratio = 1.49, P = 0.0486). Overall, K6 scores were significantly higher in those with PSS than in those without (P = 0.000013). Analysis controlling for sex and the presence of migraine showed that PSS was associated with higher K6 scores irrespective of sex or the presence of migraine. Conclusions The low prevalence of PSS identified in the present study may be due to the inadequate ability of the self‐report questionnaire to identify PSS. Despite such limitation, the present study suggests that individuals with PSS are more likely to suffer from migraine and psychological distress than those without PSS. PSS may be a potential target for the research of migraine and stress‐related disorders.

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A critical review of trials of transcranial direct current stimulation and trigeminal nerve stimulation for depression: the issue of treatment-emergent mania

Cited by 11 publications

References 39 publications

Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

Trigeminal nerve stimulation: a recently approved treatment approach in attention deficit hyperactivity disorder

Possible association between photic sneeze syndrome and migraine and psychological distress

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