A critical review of traditional and advanced characterisation tools to drive formulators towards the rational development of 3D printed oral dosage forms

Deon, Marion; Santos, Juliana dos; Andrade, Diego Fontana de; Beck, Ruy Carlos Ruver

doi:10.1016/j.ijpharm.2022.122293

Cited by 19 publications

(10 citation statements)

References 135 publications

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“…However, besides these physicochemical properties, the mechanical properties of the filaments are also decisive in determining whether they are printable or not ( Deon et al, 2022 ). In this sense, we evaluated the mechanical properties of the three different extruded filaments to evaluate whether the DEX form had any impact on them.…”

Section: Resultsmentioning

confidence: 99%

3D printed matrix solid forms: Can the drug solubility and dose customisation affect their controlled release behaviour?

Santos

Balbinot

Buchner

et al. 2023

International Journal of Pharmaceutics: X

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Section: Resultsmentioning

confidence: 99%

3D printed matrix solid forms: Can the drug solubility and dose customisation affect their controlled release behaviour?

Santos

Balbinot

Buchner

et al. 2023

International Journal of Pharmaceutics: X

Self Cite

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“…In this context, current QC strategies are not feasible anymore (107). As a result, process analytical technology (PAT) and simulation approaches could be integrated into a 3D printer to advance quality assurance (QA) together with QC (108,109). Preparation of 3D printed medication should encompass GMP, software validation, in-line process control during the printing process, non-destructive QC of the final product, cleaning validation, and QA.…”

Section: Limitations Of 3d Printing At the Point Of Carementioning

confidence: 99%

The potential of three-dimensional printing for pediatric oral solid dosage forms

Kreft,

Fanous,

Möckel

2024

Acta Pharmaceutica

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Pediatric patients often require individualized dosing of medicine due to their unique pharmacokinetic and developmental characteristics. Current methods for tailoring the dose of pediatric medications, such as tablet splitting or compounding liquid formulations, have limitations in terms of dosing accuracy and palatability. This paper explores the potential of 3D printing as a solution to address the challenges and provide tailored doses of medication for each pediatric patient. The technological overview of 3D printing is discussed, highlighting various 3D printing technologies and their suitability for pharmaceutical applications. Several individualization options with the potential to improve adherence are discussed, such as individualized dosage, custom release kinetics, tablet shape, and palatability. To integrate the preparation of 3D printed medication at the point of care, a decentralized manufacturing model is proposed. In this setup, pharmaceutical companies would routinely provide materials and instructions for 3D printing, while specialized compounding centers or hospital pharmacies perform the printing of medication. In addition, clinical opportunities of 3D printing for dose-finding trials are emphasized. On the other hand, current challenges in adequate dosing, regulatory compliance, adherence to quality standards, and maintenance of intellectual property need to be addressed for 3D printing to close the gap in personalized oral medication.

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“…The list of characterizations, the corresponding analytical approaches, and the equivalent X-ray tomography analysis are summarized in Table 1 . The same can be applied to other types of tablets, such as freeze dried or 3D printed tablet (with some modifications) [ 193 , 194 , 195 , 196 ], and it will not be discussed here. We consider compressed tablets for their simplicity in the production and their wide usage in the pharmaceutical industry.…”

Section: Tablet Characterizationmentioning

confidence: 99%

Characterization of Pharmaceutical Tablets by X-ray Tomography

et al. 2023

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Solid dosage forms such as tablets are extensively used in drug administration for their simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is one of the most valuable non-destructive techniques to investigate the internal structure of the tablets for drug product development as well as for a cost effective production process. In this work, we review the recent developments in high-resolution X-ray microtomography and its application towards different tablet characterizations. The increased availability of powerful laboratory instrumentation, as well as the advent of high brilliance and coherent 3rd generation synchrotron light sources, combined with advanced data processing techniques, are driving the application of X-ray microtomography forward as an indispensable tool in the pharmaceutical industry.

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A critical review of traditional and advanced characterisation tools to drive formulators towards the rational development of 3D printed oral dosage forms

Cited by 19 publications

References 135 publications

3D printed matrix solid forms: Can the drug solubility and dose customisation affect their controlled release behaviour?

3D printed matrix solid forms: Can the drug solubility and dose customisation affect their controlled release behaviour?

The potential of three-dimensional printing for pediatric oral solid dosage forms

Characterization of Pharmaceutical Tablets by X-ray Tomography

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