A critical review of flexible and porous SERS sensors for analytical chemistry at the point-of-sample

Restaino, Stephen M.; White, Ian M.

doi:10.1016/j.aca.2018.11.057

Cited by 111 publications

(43 citation statements)

References 114 publications

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“…The four different types of plasmonic NPs prepared above were loaded onto lter papers by a dipping method. 16,20,29,30 Filter papers (Whatman grade no. 40, 55 mm in diameter) that were dried at 50 C in an oven overnight were immersed in 10 mL of the NP solution in plastic Petri dishes (60 mm Â 15 mm).…”

Section: Preparation Of Paper-based Plasmonic Substrates and Their Phmentioning

confidence: 99%

“…The immobilization of plasmonic nanoparticles (NPs) onto exible solid surfaces has shown the possibility to full these requirements. [13][14][15][16][17][18][19][20] The use of paper-based materials could potentially bring interesting features, including high exibility, biocompatibility, and biodegradability, while providing minimal background interference upon the incorporation of plasmonic metal NPs. In addition, properly modifying paper with plasmonic NPs can readily reduce uncertain uorescence in the visible wavelength area (e.g., $440 nm) during SERS measurements, 14,21 which may be an extra benet of utilizing inexpensive paper-based materials as SERS substrate.…”

Section: Introductionmentioning

confidence: 99%

“…S1 †). 2,10,20,22 This sandwich geometry creates additional local aggregates to induce a high probability of having sensing molecules reside between the NP gaps and junctions (i.e., NP-analyte-NP arrangement), thereby notably improving the SERS sensitivity. Thus, we thoroughly examined the degree of the SERS enhancements of the initial and sandwiched analytes on plasmonic papers to understand not only the amplied EM effect associated with abundant interparticle SPR coupling and hot spots, but also the structural impact on long-term stability, reproducibility, and applicability in biological systems.…”

Section: Introductionmentioning

confidence: 99%

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Sandwiching analytes with structurally diverse plasmonic nanoparticles on paper substrates for surface enhanced Raman spectroscopy

et al. 2019

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Section: Preparation Of Paper-based Plasmonic Substrates and Their Phmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sandwiching analytes with structurally diverse plasmonic nanoparticles on paper substrates for surface enhanced Raman spectroscopy

et al. 2019

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“…A variety of ES scaffolds with proper functionalization can be assembled for SERS. Indeed, ES nanofibers were shown to be an effective SERS substrate, because of a high surface to volume ratio and special optical properties achieved through the addition of metal or oxide nanoparticles (Severyukhina et al, 2015;Chen et al, 2017;Chamuah et al, 2018;Celebioglu et al, 2019;Restaino and White, 2019). The amplification of the signal, the impregnation of electrospun scaffolds with metal nanoparticles could enhance its optical, mechanical and morphological properties.…”

Section: Introductionmentioning

confidence: 99%

Polycaprolactone-Based, Porous CaCO3 and Ag Nanoparticle Modified Scaffolds as a SERS Platform With Molecule-Specific Adsorption

et al. 2020

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Surface-enhanced Raman scattering (SERS) is a high-performance technique allowing detection of extremely low concentrations of analytes. For such applications, fibrous polymeric matrices decorated with plasmonic metal nanostructures can be used as flexible SERS substrates for analysis of analytes in many application. In this study, a three-dimensional SERS substrate consisting of a CaCO 3-mineralized electrospun (ES) polycaprolactone (PCL) fibrous matrix decorated with silver (Ag) nanoparticles is developed. Such modification of the fibrous substrate allows achieving a significant increase of the SERS signal amplification. Functionalization of fibers by porous CaCO 3 (vaterite) and Ag nanoparticles provides an effective approach of selective adsorption of biomolecules and their precise detection by SERS. This new SERS substrate represents a promising biosensor platform with selectivity to low and high molecular weight molecules.

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“…This is based on the observation, made in the late 70s-80s of the past century, that when molecules interact with roughened (nanostructured) coinage metal surfaces, and suitable exciting laser lines are adopted, some of their Raman signals result to be enhanced of several order of magnitude [1,2], thus allowing their identification even at very low concentration. Such a technique, nowadays well known as surface-enhanced Raman spectroscopy (SERS) can overcome the limitations of Raman spectroscopy, increasing its performance in fields of investigation heavily dominated by the "low concentration problem", such as those concerning bio-sensing [3][4][5][6], detection of bacteria [7], food analysis [8] and more in general analytical chemistry [9,10] are.…”

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confidence: 99%

Effective SERS substrate obtained by Au deposition at silica surfaces through a top down method

2020

Biophysical Bulletin

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Background: In the last years some of us developed methods for preparing, through simple synthesis protocols, gold nanoparticles supported on silica surfaces: in that cases, bottom-up approaches has been adopted (i.e. starting from HAuCl4 precursor) and high surface area silica (Aerosil 300) was chosen as support (together with controlled pH conditions), to facilitate Au dispersion. The obtained substrates showed the ability to enhance Raman signals of dosed molecules pyridine and bi-pyridine and/or of silanols species populating the silica surface. Following this idea, in this paper we will present results concerning surface-enhanced Raman spectroscopy (SERS) activity of substrates obtained by a top-down technique (i.e. gold sputtering) which allowed depositing gold nanoparticles at surfaces of silica nanoparticles. Pyridine molecule has been then used as a probe molecule to estimate the SERS activity of the obtained substrates. Objectives: The purpose of the work was to study the SERS activity of the prepared substrates through the estimation of limit of detection (LoD) of pyridine molecule dosed from solutions (benzene was used as solvent) with decreasing pyridine concentration. Materials and methods: For the preparation of the samples AOX50 silica (Evonik Industries, surface area of 50 m2/g) in form of pressed disk, a gold target and a K575X Turbo Sputter Coater (Quorum Technologies) were used. Methods applied: UV-Vis-NIR spectroscopy; HR-TEM microscopy; Raman spectroscopy. Results: Prepared Au/AOX50 substrates with nominal Au thickness 10 nm were characterized by the UV-Vis spectroscopy and HR-TEM microscopy. They showed a relatively complex absorption profile extending to the NIR region. The substrates contained gold nanoparticles with diameter in the range of 2.0–3.5 nm. By using the 785 nm exciting laser line (suggested by the results coming from UV-Vis spectroscopy) for recording Raman spectra, it was possible to observe characteristic pyridine Raman signals by contacting Au/AOX50 substrates with vapour phase of benzene solutions with pyridine concentration as low as 10-7 M comprising LoD. This allowed us to estimate roughly an enhancement factor of 108, as compared with 12.4 M pyridine dosed at naked AOX50 silica surface. Conclusion: Through a top-down technique it was possible to prepare effective SERS substrates composed by Au nanoparticles dispersed at AOX50 silica surfaces. LoD for pyridine dosed from the vapour of its benzene solution appeared to be 10-7 M and the SERS enhancement factor, using as a reference Raman spectra of 12.4 M pyridine interacting with naked AOX50 silica, has been estimated to be approximately 108.

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A critical review of flexible and porous SERS sensors for analytical chemistry at the point-of-sample

Cited by 111 publications

References 114 publications

Sandwiching analytes with structurally diverse plasmonic nanoparticles on paper substrates for surface enhanced Raman spectroscopy

Sandwiching analytes with structurally diverse plasmonic nanoparticles on paper substrates for surface enhanced Raman spectroscopy

Polycaprolactone-Based, Porous CaCO3 and Ag Nanoparticle Modified Scaffolds as a SERS Platform With Molecule-Specific Adsorption

Effective SERS substrate obtained by Au deposition at silica surfaces through a top down method

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