A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in
            <i>Drosophila</i>

Kayser, Matthew S.; Yue, Zhifeng; Sehgal, Amita

doi:10.1126/science.1250553

Cited by 155 publications

(236 citation statements)

References 62 publications

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“…3C). This result is consistent with a previous finding that a reduced size of the VA1v glomerulus, the target of Or47b-expressing neurons, causes courtship deficits (28). To verify that the observed phenotype was due to the loss of Or47b function, we rescued this function by introducing UASOr47b under control of Or47b-Gal4 into Or47b [3].…”

Section: Acts As a Stimulatory Pheromone To Promote Male Copulationsupporting

confidence: 75%

Pheromones mediating copulation and attraction in Drosophila

Dweck¹,

Ebrahim²,

Thoma³

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

229

257

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Intraspecific olfactory signals known as pheromones play important roles in insect mating systems. In the model Drosophila melanogaster, a key part of the pheromone-detecting system has remained enigmatic through many years of research in terms of both its behavioral significance and its activating ligands. Here we show that Or47b-and Or88a-expressing olfactory sensory neurons (OSNs) detect the fly-produced odorants methyl laurate (ML), methyl myristate, and methyl palmitate. Fruitless (fru M )-positive Or47b-expressing OSNs detect ML exclusively, and Or47b-and Or47b-expressing OSNs are required for optimal male copulation behavior. In addition, activation of Or47b-expressing OSNs in the male is sufficient to provide a competitive mating advantage. We further find that the vigorous male courtship displayed toward oenocyte-less flies is attributed to an oenocyte-independent sustained production of the Or47b ligand, ML. In addition, we reveal that Or88a-expressing OSNs respond to all three compounds, and that these neurons are necessary and sufficient for attraction behavior in both males and females. Beyond the OSN level, information regarding the three fly odorants is transferred from the antennal lobe to higher brain centers in two dedicated neural lines. Finally, we find that both Or47b-and Or88a-based systems and their ligands are remarkably conserved over a number of drosophilid species. Taken together, our results close a significant gap in the understanding of the olfactory background to Drosophila mating and attraction behavior; while reproductive isolation barriers between species are created mainly by species-specific signals, the mating enhancing signal in several Drosophila species is conserved. Drosophila | pheromone | mating | olfaction | olfactory circuit I n the vinegar fly Drosophila melanogaster, cuticular hydrocarbons (CHCs) act as pheremones and play important roles in courtship and aggregation behaviors. These pheremones include the female-specific aphrodisiacs (Z,Z)-7,11-heptacosadiene (7,11-HD) and (Z,Z)-7,11-nonacosadiene (7,11-ND) and the male specific antiaphrodisiacs (Z)-7-tricosene (7-T) and 11-cis-vaccenyl acetate (cVA) (1). However, several lines of evidence suggest that other unidentified pheromones likely contribute to courtship and aggregation behaviors. Previous studies have demonstrated that an unidentified volatile sex pheromone produced by female flies stimulates male courtship (2-6). Flies anosmic to cVA exhibit residual attraction to live male flies, suggesting that other attractive cues are produced by flies that are independent of cVA and its neural circuit (7). Furthermore, no specific ligands other than cVA have been identified for the potential pheromone receptors expressed in OSNs of antennal trichoid sensilla (8). Moreover, OSNs expressing olfactory receptors Or47a and Or88a housed in trichoid sensilla respond to unidentified odors in male and female body wash extracts (9).Although the CHC profile of D. melanogaster has been characterized by several analytical techniq...

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Section: Acts As a Stimulatory Pheromone To Promote Male Copulationsupporting

confidence: 75%

Pheromones mediating copulation and attraction in Drosophila

Dweck¹,

Ebrahim²,

Thoma³

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

229

257

View full text Add to dashboard Cite

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“…Such specialized activity could, for instance, promote appropriate neurodevelopment through feedback by coupling function (such as recurring limb movement) to the refinement of neural connections. Consistent with this notion, nonlethal deprivation can cause longlasting neurological and behavioral defects in vertebrates and invertebrates alike (Halbower et al 2006;Jan et al 2010;Kayser et al 2014). Yet a mechanistic grasp is lacking with regard to how sleep ontogeny is controlled and why inadequate sleep during development is particularly deleterious.…”

supporting

confidence: 50%

“…In addition, sleep in flies as in mammals is suppressed with drugs that are wake promoting to humans, specifically caffeine and modafinil (Hendricks et al 2000(Hendricks et al , 2001Shaw et al 2000). Remarkably, Drosophila recapitulate mammalian changes to sleep throughout their life span: young flies demonstrate increased sleep amount and depth, while old flies exhibit more fragmented sleep (Shaw et al 2000;Koh et al 2006;Seugnet et al 2011a;Kayser et al 2014). Drosophila life span is 60-80 days, and the features distinguishing juvenile sleep from that of the mature adult occur only during the first 3-5 days after eclosion (Seugnet et al 2011a;Kayser et al 2014).…”

Section: Fly Sleepmentioning

confidence: 99%

“…Drosophila life span is 60-80 days, and the features distinguishing juvenile sleep from that of the mature adult occur only during the first 3-5 days after eclosion (Seugnet et al 2011a;Kayser et al 2014). During this juvenile period, flies are far more somnolent than adult flies: they sleep more during the day, are more difficult to arouse from sleep at night, and are notably resistant to sleep deprivation (Kayser et al 2014).…”

Section: Fly Sleepmentioning

confidence: 99%

“…Remarkably, Drosophila recapitulate mammalian changes to sleep throughout their life span: young flies demonstrate increased sleep amount and depth, while old flies exhibit more fragmented sleep (Shaw et al 2000;Koh et al 2006;Seugnet et al 2011a;Kayser et al 2014). Drosophila life span is 60-80 days, and the features distinguishing juvenile sleep from that of the mature adult occur only during the first 3-5 days after eclosion (Seugnet et al 2011a;Kayser et al 2014). During this juvenile period, flies are far more somnolent than adult flies: they sleep more during the day, are more difficult to arouse from sleep at night, and are notably resistant to sleep deprivation (Kayser et al 2014).…”

Section: Fly Sleepmentioning

confidence: 99%

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Sleep and Development in Genetically Tractable Model Organisms

Kayser

Biron

2016

Genetics

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Sleep is widely recognized as essential, but without a clear singular function. Inadequate sleep impairs cognition, metabolism, immune function, and many other processes. Work in genetic model systems has greatly expanded our understanding of basic sleep neurobiology as well as introduced new concepts for why we sleep. Among these is an idea with its roots in human work nearly 50 years old: sleep in early life is crucial for normal brain maturation. Nearly all known species that sleep do so more while immature, and this increased sleep coincides with a period of exuberant synaptogenesis and massive neural circuit remodeling. Adequate sleep also appears critical for normal neurodevelopmental progression. This article describes recent findings regarding molecular and circuit mechanisms of sleep, with a focus on development and the insights garnered from models amenable to detailed genetic analyses.

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Shorter sleep duration is associated with social impairment and comorbidities in ASD

et al. 2017

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Sleep disturbance, particularly insomnia, is common in children with autism spectrum disorders (ASD). Furthermore, disturbed sleep affects core symptoms and other related comorbidities. Understanding the causes and consequences of sleep disturbances in children with ASD is an important step toward mitigating these symptoms. To better understand the connection between sleep duration and ASD severity, we analyzed ASD-related symptoms using the Autism Diagnostic Interview-Revised (ADI-R), Autism Diagnostic Observation Schedule (ADOS), IQ scores, and parent reports of the average amount of time slept per night that were available in the medical histories of 2,714 children with ASD in the Simons Simplex Collection (SSC). The mean (SD) sleep duration was 555 minutes. Sleep duration and severity of core ASD symptoms were negatively correlated, and sleep duration and IQ scores were positively correlated. Regression results indicated that more severe social impairment, primarily a failure to develop peer relationships, is the core symptom most strongly associated with short sleep duration. Furthermore, increased severity for numerous maladaptive behaviors assessed on the Child Behavior Checklist, as well as reports of attention deficit disorder, depressive disorder, and obsessive compulsive disorder were associated with short sleep duration. Severity scores for social/communication impairment and restricted and repetitive behaviors (RRB) were increased, and IQ scores were decreased, for children reported to sleep ≤420 minutes per night (lower 5th percentile) compared to children sleeping ≥660 minutes (upper 95th percentile). Our results indicate that reduced amounts of sleep are related to more severe symptoms in children with ASD. Autism Res 2017. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Autism Res 2017, 10: 1221-1238. © 2017 International Society for Autism Research, Wiley Periodicals, Inc.

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A Critical Period of Sleep for Development of Courtship Circuitry and Behavior in Drosophila

Cited by 155 publications

References 62 publications

Pheromones mediating copulation and attraction in Drosophila

Pheromones mediating copulation and attraction in Drosophila

Sleep and Development in Genetically Tractable Model Organisms

Shorter sleep duration is associated with social impairment and comorbidities in ASD

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